Activin receptor type-2A

Details

Name
Activin receptor type-2A
Synonyms
  • 2.7.11.30
  • Activin receptor type IIA
  • ACTR-IIA
  • ACTRIIA
  • ACVR2
Gene Name
ACVR2A
UniProtKB Entry
P27037Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0006743|Activin receptor type-2A
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWEKDRTNQTGVEPCYGDKDKRRHC
FATWKNISGSIEIVKQGCWLDDINCYDRTDCVEKKDSPEVYFCCCEGNMCNEKFSYFPEM
EVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGP
PPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPG
MKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGL
AYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQV
GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIG
QHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERIT
QMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
Number of residues
513
Molecular Weight
57847.12
Theoretical pI
5.76
GO Classification
Functions
activin binding / activin receptor activity / BMP receptor activity / growth factor binding / inhibin binding / PDZ domain binding
Processes
cell surface receptor protein serine/threonine kinase signaling pathway / cellular response to growth factor stimulus / odontogenesis of dentin-containing tooth / positive regulation of SMAD protein signal transduction / positive regulation of transcription by RNA polymerase II / regulation of nitric oxide biosynthetic process
Components
activin receptor complex
General Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A (PubMed:17911401). Mediates induction of adipogenesis by GDF6 (By similarity)
Specific Function
Activin binding
Pfam Domain Function
Signal Regions
1-19
Transmembrane Regions
136-161
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0017114|Activin receptor type-2A (ACVR2A)
ATGGGAGCTGCTGCAAAGTTGGCGTTTGCCGTCTTTCTTATCTCCTGTTCTTCAGGTGCT
ATACTTGGTAGATCAGAAACTCAGGAGTGTCTTTTCTTTAATGCTAATTGGGAAAAAGAC
AGAACCAATCAAACTGGTGTTGAACCGTGTTATGGTGACAAAGATAAACGGCGGCATTGT
TTTGCTACCTGGAAGAATATTTCTGGTTCCATTGAAATAGTGAAACAAGGTTGTTGGCTG
GATGATATCAACTGCTATGACAGGACTGATTGTGTAGAAAAAAAAGACAGCCCTGAAGTA
TATTTTTGTTGCTGTGAGGGCAATATGTGTAATGAAAAGTTTTCTTATTTTCCGGAGATG
GAAGTCACACAGCCCACTTCAAATCCAGTTACACCTAAGCCACCCTATTACAACATCCTG
CTCTATTCCTTGGTGCCACTTATGTTAATTGCGGGGATTGTCATTTGTGCATTTTGGGTG
TACAGGCATCACAAGATGGCCTACCCTCCTGTACTTGTTCCAACTCAAGACCCAGGACCA
CCCCCACCTTCTCCATTACTAGGTTTGAAACCACTGCAGTTATTAGAAGTGAAAGCAAGG
GGAAGATTTGGTTGTGTCTGGAAAGCCCAGTTGCTTAACGAATATGTGGCTGTCAAAATA
TTTCCAATACAGGACAAACAGTCATGGCAAAATGAATACGAAGTCTACAGTTTGCCTGGA
ATGAAGCATGAGAACATATTACAGTTCATTGGTGCAGAAAAACGAGGCACCAGTGTTGAT
GTGGATCTTTGGCTGATCACAGCATTTCATGAAAAGGGTTCACTATCAGACTTTCTTAAG
GCTAATGTGGTCTCTTGGAATGAACTGTGTCATATTGCAGAAACCATGGCTAGAGGATTG
GCATATTTACATGAGGATATACCTGGCCTAAAAGATGGCCACAAACCTGCCATATCTCAC
AGGGACATCAAAAGTAAAAATGTGCTGTTGAAAAACAACCTGACAGCTTGCATTGCTGAC
TTTGGGTTGGCCTTAAAATTTGAGGCTGGCAAGTCTGCAGGCGATACCCATGGACAGGTT
GGTACCCGGAGGTACATGGCTCCAGAGGTATTAGAGGGTGCTATAAACTTCCAAAGGGAT
GCATTTTTGAGGATAGATATGTATGCCATGGGATTAGTCCTATGGGAACTGGCTTCTCGC
TGTACTGCTGCAGATGGACCTGTAGATGAATACATGTTGCCATTTGAGGAGGAAATTGGC
CAGCATCCATCTCTTGAAGACATGCAGGAAGTTGTTGTGCATAAAAAAAAGAGGCCTGTT
TTAAGAGATTATTGGCAGAAACATGCTGGAATGGCAATGCTCTGTGAAACCATTGAAGAA
TGTTGGGATCACGACGCAGAAGCCAGGTTATCAGCTGGATGTGTAGGTGAAAGAATTACC
CAGATGCAGAGACTAACAAATATTATTACCACAGAGGACATTGTAACAGTGGTCACAATG
GTGACAAATGTTGACTTTCCTCCCAAAGAATCTAGTCTATGA
Chromosome Location
2
Locus
2q22.3-q23.1
External Identifiers
ResourceLink
UniProtKB IDP27037
UniProtKB Entry NameAVR2A_HUMAN
GenBank Gene IDBC069707
GeneCard IDACVR2A
GenAtlas IDACVR2A
HGNC IDHGNC:173
PDB ID(s)3Q4T, 3SOC, 4ASX, 5NH3, 7U5P
KEGG IDhsa:92
IUPHAR/Guide To Pharmacology ID1791
NCBI Gene ID92
General References
  1. Matzuk MM, Bradley A: Cloning of the human activin receptor cDNA reveals high evolutionary conservation. Biochim Biophys Acta. 1992 Feb 28;1130(1):105-8. [Article]
  2. Donaldson CJ, Mathews LS, Vale WW: Molecular cloning and binding properties of the human type II activin receptor. Biochem Biophys Res Commun. 1992 Apr 15;184(1):310-6. [Article]
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Associated Data

Bio-Entities
Bio-EntityType
Activin receptor type-2A (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Sotaterceptapproved, investigationalunknowntargetbinderDetails