Amine oxidase [flavin-containing] B

Details

Name
Amine oxidase [flavin-containing] B
Synonyms
  • 1.4.3.21
  • 1.4.3.4
  • MAO-B
  • Monoamine oxidase type B
Gene Name
MAOB
UniProtKB Entry
P27338Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0004309|Amine oxidase [flavin-containing] B
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWR
TMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQ
TRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVY
YKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEER
LKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTT
FLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
Number of residues
520
Molecular Weight
58762.475
Theoretical pI
7.55
GO Classification
Functions
aliphatic amine oxidase activity / electron transfer activity / identical protein binding / monoamine oxidase activity
Processes
phenylethylamine catabolic process / response to xenobiotic stimulus
Components
dendrite / neuronal cell body
General Function
Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924). Preferentially degrades benzylamine and phenylethylamine (PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924)
Specific Function
aliphatic amine oxidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
490-516
Cellular Location
Mitochondrion outer membrane
Gene sequence
>lcl|BSEQ0016709|Amine oxidase [flavin-containing] B (MAOB)
ATGAGCAACAAATGCGACGTGGTCGTGGTGGGGGGCGGCATCTCAGGTATGGCAGCAGCC
AAACTTCTGCATGACTCTGGACTGAATGTGGTTGTTCTGGAAGCCCGGGACCGTGTGGGA
GGCAGGACTTACACTCTTAGGAACCAAAAGGTTAAATATGTGGACCTTGGAGGATCCTAT
GTTGGACCAACCCAGAATCGTATCTTGAGATTAGCCAAGGAGCTAGGATTGGAGACCTAC
AAAGTGAATGAGGTTGAGCGTCTGATCCACCATGTAAAGGGCAAATCATACCCCTTCAGG
GGGCCATTCCCACCTGTATGGAATCCAATTACCTACTTAGATCATAACAACTTTTGGAGG
ACAATGGATGACATGGGGCGAGAGATTCCGAGTGATGCCCCATGGAAGGCTCCCCTTGCA
GAAGAGTGGGACAACATGACAATGAAGGAGCTACTGGACAAGCTCTGCTGGACTGAATCT
GCAAAGCAGCTTGCCACTCTCTTTGTGAACCTGTGTGTCACTGCAGAGACCCATGAGGTC
TCTGCTCTCTGGTTCCTGTGGTATGTGAAGCAGTGTGGAGGCACAACAAGAATCATCTCG
ACAACAAATGGAGGACAGGAGAGGAAATTTGTGGGCGGATCTGGTCAAGTGAGTGAGCGG
ATAATGGACCTCCTTGGAGACCGAGTGAAGCTGGAGAGGCCTGTGATCTACATTGACCAG
ACAAGAGAAAATGTCCTTGTGGAGACCCTAAACCATGAGATGTATGAGGCTAAATATGTG
ATTAGTGCTATTCCTCCTACTCTGGGCATGAAGATTCACTTCAATCCCCCTCTGCCAATG
ATGAGAAACCAGATGATCACTCGTGTGCCTTTGGGTTCAGTCATCAAGTGTATAGTTTAT
TATAAAGAGCCTTTCTGGAGGAAAAAGGATTACTGTGGAACCATGATTATTGATGGAGAA
GAAGCTCCAGTTGCCTACACGTTGGATGATACCAAACCTGAAGGCAACTATGCTGCCATA
ATGGGATTTATCCTGGCCCACAAAGCCAGAAAACTGGCACGTCTTACCAAAGAGGAAAGG
TTGAAGAAACTTTGTGAACTCTATGCCAAGGTTCTGGGTTCCCTAGAAGCTCTGGAGCCA
GTGCATTATGAAGAAAAGAACTGGTGTGAGGAGCAGTACTCTGGGGGCTGCTACACAACT
TATTTCCCCCCTGGGATCCTGACTCAATATGGAAGGGTTCTACGCCAGCCAGTGGACAGG
ATTTACTTTGCAGGCACCGAGACTGCCACACACTGGAGCGGCTACATGGAGGGGGCTGTA
GAGGCCGGGGAGAGAGCAGCCCGAGAGATCCTGCATGCCATGGGGAAGATTCCAGAGGAT
GAAATCTGGCAGTCAGAACCAGAGTCTGTGGATGTCCCTGCACAGCCCATCACCACCACC
TTTTTGGAGAGACATTTGCCCTCCGTGCCAGGCCTGCTCAGGCTGATTGGATTGACCACC
ATCTTTTCAGCAACGGCTCTTGGCTTCCTGGCCCACAAAAGGGGGCTACTTGTGAGAGTC
TAA
Chromosome Location
X
Locus
Xp11.3
External Identifiers
ResourceLink
UniProtKB IDP27338
UniProtKB Entry NameAOFB_HUMAN
GenBank Protein ID398415
GenBank Gene IDS62734
GeneCard IDMAOB
GenAtlas IDMAOB
HGNC IDHGNC:6834
PDB ID(s)1GOS, 1OJ9, 1OJA, 1OJC, 1OJD, 1S2Q, 1S2Y, 1S3B, 1S3E, 2BK3, 2BK4, 2BK5, 2BYB, 2C64, 2C65, 2C66, 2C67, 2C70, 2C72, 2C73, 2C75, 2C76, 2V5Z, 2V60, 2V61, 2VRL, 2VRM, 2VZ2, 2XCG, 2XFN, 2XFO, 2XFP, 2XFQ, 2XFU, 3PO7, 3ZYX, 4A79, 4A7A, 4CRT, 5MRL, 6FVZ, 6FW0, 6FWC, 6RKB, 6RKP, 6RLE, 6YT2, 7B0V, 7B0Z, 7P4F, 7P4H, 7ZW3
KEGG IDhsa:4129
IUPHAR/Guide To Pharmacology ID2490
NCBI Gene ID4129
General References
  1. Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC: Human monoamine oxidase A and B genes exhibit identical exon-intron organization. Proc Natl Acad Sci U S A. 1991 May 1;88(9):3637-41. [Article]
  2. Bach AW, Lan NC, Johnson DL, Abell CW, Bembenek ME, Kwan SW, Seeburg PH, Shih JC: cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4934-8. [Article]
  3. Chen K, Wu HF, Shih JC: The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical. J Neurochem. 1993 Jul;61(1):187-90. [Article]
  4. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  6. Zhu QS, Grimsby J, Chen K, Shih JC: Promoter organization and activity of human monoamine oxidase (MAO) A and B genes. J Neurosci. 1992 Nov;12(11):4437-46. [Article]
  7. Newton-Vinson P, Hubalek F, Edmondson DE: High-level expression of human liver monoamine oxidase B in Pichia pastoris. Protein Expr Purif. 2000 Nov;20(2):334-45. [Article]
  8. Cesura AM, Gottowik J, Lahm HW, Lang G, Imhof R, Malherbe P, Rothlisberger U, Da Prada M: Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis. Eur J Biochem. 1996 Mar 15;236(3):996-1002. [Article]
  9. Wu HF, Chen K, Shih JC: Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines. Mol Pharmacol. 1993 Jun;43(6):888-93. [Article]
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  11. Binda C, Newton-Vinson P, Hubalek F, Edmondson DE, Mattevi A: Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nat Struct Biol. 2002 Jan;9(1):22-6. [Article]
  12. Binda C, Li M, Hubalek F, Restelli N, Edmondson DE, Mattevi A: Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9750-5. Epub 2003 Aug 11. [Article]
  13. Binda C, Hubalek F, Li M, Herzig Y, Sterling J, Edmondson DE, Mattevi A: Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class. J Med Chem. 2004 Mar 25;47(7):1767-74. [Article]
  14. Hubalek F, Binda C, Khalil A, Li M, Mattevi A, Castagnoli N, Edmondson DE: Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem. 2005 Apr 22;280(16):15761-6. Epub 2005 Feb 14. [Article]
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Associated Data

Bio-Entities
Bio-EntityType
Amine oxidase [flavin-containing] B (Humans)protein
primary
Monoamine oxidase (Humans)protein
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
PhenelzineapprovedyestargetantagonistDetails
Selegilineapproved, investigational, vet_approvedyestargetinhibitorDetails
Tranylcypromineapproved, investigationalyestargetinhibitorDetails
Phentermineapproved, illicityestargetantagonistDetails
IsocarboxazidapprovedyestargetinhibitorDetails
IsatinexperimentalyestargetinhibitorDetails
(R)-N-methyl-N-2-propynyl-1-indanamineexperimentalyestargetinhibitorDetails
RasagilineapprovedyestargetinhibitorDetails
FarnesolexperimentalyestargetinhibitorDetails
Flavin adenine dinucleotideapprovedyestargetinhibitorDetails
N-Propargyl-1(S)-AminoindanexperimentalyestargetinhibitorDetails
Dodecyldimethylamine N-oxideexperimentalunknowntargetligandDetails
5-Hydroxy-N-Propargyl-1(R)-AminoindanexperimentalunknowntargetligandDetails
N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINEexperimentalunknowntargetDetails
EVT 302investigationalunknowntargetDetails
Safinamideapproved, investigationalyestargetantagonistDetails
Furazolidoneexperimental, vet_approvedunknownenzymeinhibitorDetails
PhenelzineapprovedunknownenzymesubstrateDetails
AmantadineapprovedunknownenzymeinhibitorDetails
Moclobemideapproved, investigationalunknownenzymeinhibitorDetails
IsatinexperimentalunknownenzymeinhibitorDetails
(R)-N-methyl-N-2-propynyl-1-indanamineexperimentalunknownenzymeDetails
FarnesolexperimentalunknownenzymeinhibitorDetails
Flavin adenine dinucleotideapprovedunknownenzymeDetails
N-Propargyl-1(S)-AminoindanexperimentalunknownenzymeinhibitorDetails
Dodecyldimethylamine N-oxideexperimentalunknownenzymeligandDetails
5-Hydroxy-N-Propargyl-1(R)-AminoindanexperimentalunknownenzymeligandDetails
IproniazidwithdrawnunknownenzymeinhibitorDetails
BicifadineinvestigationalunknownenzymesubstrateDetails
DopamineapprovedunknownenzymesubstrateDetails
Zonisamideapproved, investigationalunknowntargetinhibitorDetails
SertralineapprovedunknownenzymesubstrateDetails
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-PropanesulfonateexperimentalunknowntargetDetails
7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDEexperimentalyestargetinhibitorDetails
7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONEexperimentalunknowntargetDetails
N-(2-AMINOETHYL)-P-CHLOROBENZAMIDEexperimentalunknowntargetDetails
(1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINEexperimentalunknowntargetDetails
4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDANexperimentalyestargetinhibitorDetails
(S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE]experimentalunknowntargetDetails
PargylineapprovedyestargetinhibitorDetails
4-Methoxyamphetamineexperimental, illicitunknowntargetinhibitorDetails
Ephedra sinica rootnutraceuticalyestargetinhibitorDetails
MMDAexperimental, illicityestargetinhibitorDetails
Metamfetamineapproved, illicit, withdrawnyestargetinhibitorDetails
NicotineapprovedunknownenzymeinhibitorDetails
Linezolidapproved, investigationalnoenzymeinhibitorDetails
Zimelidineapproved, withdrawnunknowntargetinhibitorDetails
Nialamideapproved, withdrawnunknowntargetDetails
Nomifensineapproved, withdrawnunknowntargetDetails
Nandrolone decanoateapproved, illicitunknownenzymeinhibitorDetails
Amphetamineapproved, illicit, investigationalunknowntargetinhibitorDetails
Pioglitazoneapproved, investigationalunknowntargetinhibitorDetails
Moclobemideapproved, investigationalunknowntargetantagonistDetails
PhenylephrineapprovedunknownenzymesubstrateDetails
Ozanimodapproved, investigationalunknowntransporterinhibitorDetails
Ozanimodapproved, investigationalunknownenzymesubstrateDetails
Tedizolidapproved, investigationalnoenzymeinhibitorDetails
Tedizolid phosphateapprovednoenzymeinhibitorDetails
Flortaucipir F-18approved, investigationalnotargetbinderDetails
VafidemstatinvestigationalunknowntargetinhibitorDetails
Viloxazineapproved, investigational, withdrawnunknowntargetinhibitorDetails
EscitalopramapprovednoenzymesubstrateDetails
CitalopramapprovednoenzymesubstrateDetails
Ferulic acidexperimentalyestargetinhibitorDetails
P-HydroxybenzaldehydeexperimentalyestargetinhibitorDetails
EugenolapprovedyestargetinhibitorDetails
ToloxatoneexperimentalyestargetinhibitorDetails
IproniazidwithdrawnyestargetinhibitorDetails
5-QUINOXALIN-6-YLMETHYLENE-THIAZOLIDINE-2,4-DIONEexperimentalyestargetinhibitorDetails
PiperineinvestigationalyestargetinhibitorDetails
IndantadolinvestigationalyestargetinhibitorDetails
LadostigilinvestigationalyestargetinhibitorDetails
BudipineexperimentalyestargetmodulatorDetails
Sulfadoxineapproved, investigationalyestargetinhibitorDetails
PsoraleninvestigationalyestargetinhibitorDetails
TryptamineexperimentalyestargetinhibitorDetails
ProtocatechualdehydeexperimentalyestargetinhibitorDetails
4-hydroxybenzoic acidexperimentalyestargetinhibitorDetails
Procaineapproved, investigational, vet_approvedunknowntargetinhibitorDetails
Amphetamineapproved, illicit, investigationalyestargetinhibitorDetails
Procarbazineapproved, investigationalyestargetinhibitorDetails
Copperapproved, investigationalunknownenzymecofactorDetails
Moclobemideapproved, investigationalunknowntargetantagonistDetails
Rauwolfia serpentina rootinvestigationalunknownenzymesubstrateDetails
Epinephrineapproved, vet_approvedunknownenzymesubstrateDetails
Betahistineapproved, investigationalunknownenzymesubstrateDetails