Leukocyte tyrosine kinase receptor

Details

Name
Leukocyte tyrosine kinase receptor
Synonyms
  • 2.7.10.1
  • Protein tyrosine kinase 1
  • TYK1
Gene Name
LTK
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051794|Leukocyte tyrosine kinase receptor
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN
SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL
ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL
RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC
SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF
LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK
PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA
PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ
VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS
FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA
KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG
YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC
TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL
SSGLKPLKSRGLQPQNLWNPTYRS
Number of residues
864
Molecular Weight
91680.525
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / protein kinase activity / protein tyrosine kinase activity / transmembrane receptor protein tyrosine kinase activity
Processes
cell proliferation / cellular response to retinoic acid / negative regulation of apoptotic process / phosphatidylinositol 3-kinase signaling / positive regulation of cardiac muscle cell apoptotic process / positive regulation of neuron projection development / protein phosphorylation / signal transduction / transmembrane receptor protein tyrosine kinase signaling pathway
Components
integral component of plasma membrane / intracellular / membrane / plasma membrane
General Function
Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
425-449
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0051795|Leukocyte tyrosine kinase receptor (LTK)
ATGGGCTGCTGGGGACAGCTGCTGGTGTGGTTCGGAGCCGCGGGCGCCATTCTCTGCTCT
AGCCCGGGGTCCCAGGAGACTTTTCTGCGGTCCTCGCCCCTGCCGCTGGCAAGTCCCAGC
CCCCGGGACCCGAAAGTCAGCGCCCCGCCTAGTATCTTGGAGCCAGCCTCCCCGCTGAAT
TCTCCGGGCACCGAGGGGTCTTGGCTGTTTTCTACCTGCGGGGCCAGCGGCCGGCATGGG
CCCACACAGACACAATGTGACGGGGCGTACGCGGGGACCAGCGTGGTGGTGACCGTGGGG
GCCGCCGGGCAGCTGAGAGGCGTGCAGCTGTGGCGCGTGCCGGGCCCTGGCCAGTATCTG
ATCTCAGCCTACGGAGCCGCGGGCGGCAAAGGCGCCAAGAACCACCTGTCGCGGGCGCAT
GGCGTCTTCGTCTCAGCAATCTTCTCCCTCGGTCTCGGGGAGTCGCTGTACATCCTGGTG
GGGCAGCAGGGAGAGGACGCCTGTCCCGGAGGTAGCCCGGAGAGCCAGCTCGTCTGCCTC
GGGGAGTCTCGAGCCGTTGAAGAGCACGCGGCGATGGATGGGAGCGAAGGGGTCCCGGGG
TCGCGGCGCTGGGCGGGAGGTGGCGGGGGTGGCGGGGGCGCCACCTACGTTTTCCGGGTG
CGCGCTGGCGAGCTGGAACCGTTGCTGGTGGCGGCCGGAGGCGGCGGTCGGGCCTACCTG
AGGCCGCGGGACCGAGGCCGGACTCAGGCCTCCCCCGAGAAACTGGAGAACCGCTCGGAG
GCGCCCGGGAGCGGCGGGAGAGGCGGGGCGGCAGGTGGTGGGGGCGGCTGGACGTCGCGG
GCTCCCTCTCCGCAGGCCGGCCGCTCACTGCAGGAGGGGGCGGAGGGCGGCCAGGGCTGC
TCCGAGGCTTGGGCGACCCTTGGCTGGGCCGCGGCCGGCGGCTTCGGGGGCGGCGGCGGG
GCCTGCACTGCGGGCGGAGGCGGCGGCGGCTACAGGGGGGGCGACGCTTCAGAGACTGAC
AACCTCTGGGCTGATGGGGAAGATGGAGTATCCTTCATACACCCCAGCAGCGAGCTCTTC
CTGCAGCCTCTGGCAGTCACCGAGAACCACGGAGAGGTAGAGATCCGAAGGCACCTCAAC
TGCAGTCACTGCCCTTTGAGAGACTGCCAATGGCAGGCAGAGCTCCAGCTGGCTGAATGC
CTGTGCCCAGAAGGCATGGAGCTAGCTGTGGATAACGTCACCTGCATGGACCTGCACAAG
CCCCCAGGCCCTCTGGTTCTGATGGTGGCTGTGGTGGCAACCTCAACACTGAGCCTCCTT
ATGGTGTGTGGGGTCCTGATTCTGGTGAAGCAGAAGAAGTGGCAGGGCCTGCAGGAGATG
AGGCTGCCGAGCCCTGAGCTTGAGCTGAGCAAGCTTCGAACCTCTGCCATCAGGACAGCC
CCCAATCCCTATTATTGCCAGGTGGGGCTTGGCCCGGCCCAGTCCTGGCCTCTGCCACCA
GGTGTCACCGAGGTTTCCCCAGCCAATGTTACTCTGCTCAGAGCCCTGGGCCATGGTGCC
TTTGGGGAGGTGTATGAGGGACTGGTAATTGGCCTTCCTGGGGACTCCAGTCCCCTGCAG
GTAGCTATCAAGACCCTGCCAGAACTCTGCTCGCCTCAGGATGAGCTGGATTTCCTCATG
GAGGCCCTCATCATCAGCAAGTTTCGCCATCAGAACATTGTGCGGTGTGTGGGGCTCAGC
CTCAGGGCCACCCCTCGCCTCATTCTGCTGGAACTGATGTCTGGAGGGGACATGAAGAGT
TTCCTGAGGCACAGTCGGCCACACCTGGGCCAGCCATCACCTCTGGTCATGCGGGACCTG
CTGCAACTGGCCCAGGACATAGCCCAGGGCTGCCACTACCTGGAGGAAAATCACTTCATC
CACAGGGATATTGCCGCCCGGAACTGCCTGCTGAGCTGCGCTGGACCCAGCCGAGTGGCC
AAGATTGGGGACTTTGGGATGGCACGAGATATCTACCGGGCCAGTTATTACCGCAGGGGG
GACCGGGCCTTGCTCCCAGTCAAGTGGATGCCCCCAGAGGCCTTCCTGGAGGGCATCTTC
ACATCCAAGACAGATTCCTGGTCTTTTGGGGTGCTGCTCTGGGAGATCTTCTCACTGGGC
TACATGCCCTATCCTGGGCGCACCAACCAGGAGGTGCTGGACTTCGTCGTTGGAGGAGGC
CGGATGGACCCTCCTAGGGGCTGCCCAGGGCCTGTGTACCGCATCATGACCCAGTGTTGG
CAGCACGAGCCTGAGCTCCGCCCTAGCTTTGCCAGCATCTTGGAGCGTCTGCAGTACTGC
ACTCAGGACCCGGATGTGCTGAATTCACTCCTGCCAATGGAGCTGGGGCCCACCCCAGAG
GAGGAAGGGACTTCTGGGCTGGGGAACAGATCTTTGGAGTGCCTAAGACCCCCACAGCCC
CAGGAACTGAGTCCAGAGAAGTTGAAAAGCTGGGGAGGTAGCCCTCTTGGCCCCTGGCTG
TCCTCTGGCCTCAAGCCCCTCAAATCCAGGGGCCTCCAACCTCAGAACCTTTGGAATCCC
ACTTATCGCTCCTGA
Chromosome Location
15
Locus
15q15.1
External Identifiers
ResourceLink
UniProtKB IDP29376
UniProtKB Entry NameLTK_HUMAN
HGNC IDHGNC:6721
General References
  1. Toyoshima H, Kozutsumi H, Maru Y, Hagiwara K, Furuya A, Mioh H, Hanai N, Takaku F, Yazaki Y, Hirai H: Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5404-8. [Article]
  2. Krolewski JJ, Dalla-Favera R: The ltk gene encodes a novel receptor-type protein tyrosine kinase. EMBO J. 1991 Oct;10(10):2911-9. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [Article]
  5. Maru Y, Hirai H, Takaku F: Human ltk: gene structure and preferential expression in human leukemic cells. Oncogene Res. 1990;5(3):199-204. [Article]
  6. Krolewski JJ, Lee R, Eddy R, Shows TB, Dalla-Favera R: Identification and chromosomal mapping of new human tyrosine kinase genes. Oncogene. 1990 Mar;5(3):277-82. [Article]
  7. Kozutsumi H, Toyoshima H, Hagiwara K, Yazaki Y, Hirai H: Human ltk receptor tyrosine kinase binds to PLC-gamma 1, PI3-K, GAP and Raf-1 in vivo. Oncogene. 1994 Oct;9(10):2991-8. [Article]
  8. Ueno H, Honda H, Nakamoto T, Yamagata T, Sasaki K, Miyagawa K, Mitani K, Yazaki Y, Hirai H: The phosphatidylinositol 3' kinase pathway is required for the survival signal of leukocyte tyrosine kinase. Oncogene. 1997 Jun 26;14(25):3067-72. [Article]
  9. Honda H, Harada K, Komuro I, Terasaki F, Ueno H, Tanaka Y, Kawamura K, Yazaki Y, Hirai H: Heart-specific activation of LTK results in cardiac hypertrophy, cardiomyocyte degeneration and gene reprogramming in transgenic mice. Oncogene. 1999 Jul 1;18(26):3821-30. [Article]
  10. Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum Mol Genet. 2004 Jan 15;13(2):171-9. [Article]
  11. Yamada S, Nomura T, Takano K, Fujita S, Miyake M, Miyake J: Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth. Neuroreport. 2008 Nov 19;19(17):1733-8. doi: 10.1097/WNR.0b013e3283186bf8. [Article]
  12. Pao-Chun L, Chan PM, Chan W, Manser E: Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling. J Biol Chem. 2009 Dec 11;284(50):34954-63. doi: 10.1074/jbc.M109.072660. Epub 2009 Oct 8. [Article]
  13. Farhan H, Wendeler MW, Mitrovic S, Fava E, Silberberg Y, Sharan R, Zerial M, Hauri HP: MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening. J Cell Biol. 2010 Jun 14;189(6):997-1011. doi: 10.1083/jcb.200912082. [Article]
  14. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails