Leukocyte tyrosine kinase receptor
Details
- Name
- Leukocyte tyrosine kinase receptor
- Synonyms
- 2.7.10.1
- Protein tyrosine kinase 1
- TYK1
- Gene Name
- LTK
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051794|Leukocyte tyrosine kinase receptor MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLN SPGTEGSWLFSTCGASGRHGPTQTQCDGAYAGTSVVVTVGAAGQLRGVQLWRVPGPGQYL ISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYL RPRDRGRTQASPEKLENRSEAPGSGGRGGAAGGGGGWTSRAPSPQAGRSLQEGAEGGQGC SEAWATLGWAAAGGFGGGGGACTAGGGGGGYRGGDASETDNLWADGEDGVSFIHPSSELF LQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHK PPGPLVLMVAVVATSTLSLLMVCGVLILVKQKKWQGLQEMRLPSPELELSKLRTSAIRTA PNPYYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGLVIGLPGDSSPLQ VAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGGDMKS FLRHSRPHLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVA KIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLG YMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASILERLQYC TQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGGSPLGPWL SSGLKPLKSRGLQPQNLWNPTYRS
- Number of residues
- 864
- Molecular Weight
- 91680.525
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / protein kinase activity / protein tyrosine kinase activity / transmembrane receptor protein tyrosine kinase activityProcessescell proliferation / cellular response to retinoic acid / negative regulation of apoptotic process / phosphatidylinositol 3-kinase signaling / positive regulation of cardiac muscle cell apoptotic process / positive regulation of neuron projection development / protein phosphorylation / signal transduction / transmembrane receptor protein tyrosine kinase signaling pathwayComponentsintegral component of plasma membrane / intracellular / membrane / plasma membrane
- General Function
- Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.
- Specific Function
- Atp binding
- Pfam Domain Function
- PK_Tyr_Ser-Thr (PF07714)
- Transmembrane Regions
- 425-449
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0051795|Leukocyte tyrosine kinase receptor (LTK) ATGGGCTGCTGGGGACAGCTGCTGGTGTGGTTCGGAGCCGCGGGCGCCATTCTCTGCTCT AGCCCGGGGTCCCAGGAGACTTTTCTGCGGTCCTCGCCCCTGCCGCTGGCAAGTCCCAGC CCCCGGGACCCGAAAGTCAGCGCCCCGCCTAGTATCTTGGAGCCAGCCTCCCCGCTGAAT TCTCCGGGCACCGAGGGGTCTTGGCTGTTTTCTACCTGCGGGGCCAGCGGCCGGCATGGG CCCACACAGACACAATGTGACGGGGCGTACGCGGGGACCAGCGTGGTGGTGACCGTGGGG GCCGCCGGGCAGCTGAGAGGCGTGCAGCTGTGGCGCGTGCCGGGCCCTGGCCAGTATCTG ATCTCAGCCTACGGAGCCGCGGGCGGCAAAGGCGCCAAGAACCACCTGTCGCGGGCGCAT GGCGTCTTCGTCTCAGCAATCTTCTCCCTCGGTCTCGGGGAGTCGCTGTACATCCTGGTG GGGCAGCAGGGAGAGGACGCCTGTCCCGGAGGTAGCCCGGAGAGCCAGCTCGTCTGCCTC GGGGAGTCTCGAGCCGTTGAAGAGCACGCGGCGATGGATGGGAGCGAAGGGGTCCCGGGG TCGCGGCGCTGGGCGGGAGGTGGCGGGGGTGGCGGGGGCGCCACCTACGTTTTCCGGGTG CGCGCTGGCGAGCTGGAACCGTTGCTGGTGGCGGCCGGAGGCGGCGGTCGGGCCTACCTG AGGCCGCGGGACCGAGGCCGGACTCAGGCCTCCCCCGAGAAACTGGAGAACCGCTCGGAG GCGCCCGGGAGCGGCGGGAGAGGCGGGGCGGCAGGTGGTGGGGGCGGCTGGACGTCGCGG GCTCCCTCTCCGCAGGCCGGCCGCTCACTGCAGGAGGGGGCGGAGGGCGGCCAGGGCTGC TCCGAGGCTTGGGCGACCCTTGGCTGGGCCGCGGCCGGCGGCTTCGGGGGCGGCGGCGGG GCCTGCACTGCGGGCGGAGGCGGCGGCGGCTACAGGGGGGGCGACGCTTCAGAGACTGAC AACCTCTGGGCTGATGGGGAAGATGGAGTATCCTTCATACACCCCAGCAGCGAGCTCTTC CTGCAGCCTCTGGCAGTCACCGAGAACCACGGAGAGGTAGAGATCCGAAGGCACCTCAAC TGCAGTCACTGCCCTTTGAGAGACTGCCAATGGCAGGCAGAGCTCCAGCTGGCTGAATGC CTGTGCCCAGAAGGCATGGAGCTAGCTGTGGATAACGTCACCTGCATGGACCTGCACAAG CCCCCAGGCCCTCTGGTTCTGATGGTGGCTGTGGTGGCAACCTCAACACTGAGCCTCCTT ATGGTGTGTGGGGTCCTGATTCTGGTGAAGCAGAAGAAGTGGCAGGGCCTGCAGGAGATG AGGCTGCCGAGCCCTGAGCTTGAGCTGAGCAAGCTTCGAACCTCTGCCATCAGGACAGCC CCCAATCCCTATTATTGCCAGGTGGGGCTTGGCCCGGCCCAGTCCTGGCCTCTGCCACCA GGTGTCACCGAGGTTTCCCCAGCCAATGTTACTCTGCTCAGAGCCCTGGGCCATGGTGCC TTTGGGGAGGTGTATGAGGGACTGGTAATTGGCCTTCCTGGGGACTCCAGTCCCCTGCAG GTAGCTATCAAGACCCTGCCAGAACTCTGCTCGCCTCAGGATGAGCTGGATTTCCTCATG GAGGCCCTCATCATCAGCAAGTTTCGCCATCAGAACATTGTGCGGTGTGTGGGGCTCAGC CTCAGGGCCACCCCTCGCCTCATTCTGCTGGAACTGATGTCTGGAGGGGACATGAAGAGT TTCCTGAGGCACAGTCGGCCACACCTGGGCCAGCCATCACCTCTGGTCATGCGGGACCTG CTGCAACTGGCCCAGGACATAGCCCAGGGCTGCCACTACCTGGAGGAAAATCACTTCATC CACAGGGATATTGCCGCCCGGAACTGCCTGCTGAGCTGCGCTGGACCCAGCCGAGTGGCC AAGATTGGGGACTTTGGGATGGCACGAGATATCTACCGGGCCAGTTATTACCGCAGGGGG GACCGGGCCTTGCTCCCAGTCAAGTGGATGCCCCCAGAGGCCTTCCTGGAGGGCATCTTC ACATCCAAGACAGATTCCTGGTCTTTTGGGGTGCTGCTCTGGGAGATCTTCTCACTGGGC TACATGCCCTATCCTGGGCGCACCAACCAGGAGGTGCTGGACTTCGTCGTTGGAGGAGGC CGGATGGACCCTCCTAGGGGCTGCCCAGGGCCTGTGTACCGCATCATGACCCAGTGTTGG CAGCACGAGCCTGAGCTCCGCCCTAGCTTTGCCAGCATCTTGGAGCGTCTGCAGTACTGC ACTCAGGACCCGGATGTGCTGAATTCACTCCTGCCAATGGAGCTGGGGCCCACCCCAGAG GAGGAAGGGACTTCTGGGCTGGGGAACAGATCTTTGGAGTGCCTAAGACCCCCACAGCCC CAGGAACTGAGTCCAGAGAAGTTGAAAAGCTGGGGAGGTAGCCCTCTTGGCCCCTGGCTG TCCTCTGGCCTCAAGCCCCTCAAATCCAGGGGCCTCCAACCTCAGAACCTTTGGAATCCC ACTTATCGCTCCTGA
- Chromosome Location
- 15
- Locus
- 15q15.1
- External Identifiers
Resource Link UniProtKB ID P29376 UniProtKB Entry Name LTK_HUMAN HGNC ID HGNC:6721 - General References
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