Adenosine receptor A1
Details
- Name
- Adenosine receptor A1
- Synonyms
- Not Available
- Gene Name
- ADORA1
- UniProtKB Entry
- P30542Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0000026|Adenosine receptor A1 MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL KIWNDHFRCQPAPPIDEDLPEERPDD
- Number of residues
- 326
- Molecular Weight
- 36511.325
- Theoretical pI
- 8.75
- GO Classification
- FunctionsG protein-coupled adenosine receptor activity / G protein-coupled receptor binding / G-protein beta/gamma-subunit complex binding / heat shock protein binding / heterotrimeric G-protein binding / protein heterodimerization activityProcessesadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / fatty acid homeostasis / G protein-coupled receptor signaling pathway / leukocyte migration / long-term synaptic depression / mucus secretion / negative regulation of cell population proliferation / negative regulation of long-term synaptic depression / negative regulation of long-term synaptic potentiation / negative regulation of systemic arterial blood pressure / positive regulation of lipid catabolic process / positive regulation of MAPK cascade / positive regulation of systemic arterial blood pressure / regulation of cardiac muscle cell contraction / regulation of presynaptic cytosolic calcium ion concentration / regulation of respiratory gaseous exchange by nervous system process / response to purine-containing compound / triglyceride homeostasis / vasodilationComponentscalyx of Held / dendrite / synapse
- General Function
- Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
- Specific Function
- G protein-coupled adenosine receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 11-33 47-69 81-102 124-146 177-201 236-259 268-292
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010133|Adenosine receptor A1 (ADORA1) ATGCCGCCCTCCATCTCAGCTTTCCAGGCCGCCTACATCGGCATCGAGGTGCTCATCGCC CTGGTCTCTGTGCCCGGGAACGTGCTGGTGATCTGGGCGGTGAAGGTGAACCAGGCGCTG CGGGATGCCACCTTCTGCTTCATCGTGTCGCTGGCGGTGGCTGATGTGGCCGTGGGTGCC CTGGTCATCCCCCTCGCCATCCTCATCAACATTGGGCCACAGACCTACTTCCACACCTGC CTCATGGTTGCCTGTCCGGTCCTCATCCTCACCCAGAGCTCCATCCTGGCCCTGCTGGCA ATTGCTGTGGACCGCTACCTCCGGGTCAAGATCCCTCTCCGGTACAAGATGGTGGTGACC CCCCGGAGGGCGGCGGTGGCCATAGCCGGCTGCTGGATCCTCTCCTTCGTGGTGGGACTG ACCCCTATGTTTGGCTGGAACAATCTGAGTGCGGTGGAGCGGGCCTGGGCAGCCAACGGC AGCATGGGGGAGCCCGTGATCAAGTGCGAGTTCGAGAAGGTCATCAGCATGGAGTACATG GTCTACTTCAACTTCTTTGTGTGGGTGCTGCCCCCGCTTCTCCTCATGGTCCTCATCTAC CTGGAGGTCTTCTACCTAATCCGCAAGCAGCTCAACAAGAAGGTGTCGGCCTCCTCCGGC GACCCGCAGAAGTACTATGGGAAGGAGCTGAAGATCGCCAAGTCGCTGGCCCTCATCCTC TTCCTCTTTGCCCTCAGCTGGCTGCCTTTGCACATCCTCAACTGCATCACCCTCTTCTGC CCGTCCTGCCACAAGCCCAGCATCCTTACCTACATTGCCATCTTCCTCACGCACGGCAAC TCGGCCATGAACCCCATTGTCTATGCCTTCCGCATCCAGAAGTTCCGCGTCACCTTCCTT AAGATTTGGAATGACCATTTCCGCTGCCAGCCTGCACCTCCCATTGACGAGGATCTCCCA GAAGAGAGGCCTGATGACTAG
- Chromosome Location
- 1
- Locus
- 1q32.1
- External Identifiers
Resource Link UniProtKB ID P30542 UniProtKB Entry Name AA1R_HUMAN GenBank Protein ID 256155 GenBank Gene ID S45235 GeneCard ID ADORA1 GenAtlas ID ADORA1 HGNC ID HGNC:262 PDB ID(s) 5N2S, 5UEN, 6D9H, 7LD3, 7LD4 KEGG ID hsa:134 IUPHAR/Guide To Pharmacology ID 18 NCBI Gene ID 134 - General References
- Libert F, Van Sande J, Lefort A, Czernilofsky A, Dumont JE, Vassart G, Ensinger HA, Mendla KD: Cloning and functional characterization of a human A1 adenosine receptor. Biochem Biophys Res Commun. 1992 Sep 16;187(2):919-26. [Article]
- Townsend-Nicholson A, Shine J: Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA. Brain Res Mol Brain Res. 1992 Dec;16(3-4):365-70. [Article]
- Ren H, Stiles GL: Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing. J Biol Chem. 1994 Jan 28;269(4):3104-10. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Adenosine receptor A1 (Humans) protein primaryAdenosine receptor (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Caffeine approved yes target antagonist Details Gabapentin approved, investigational unknown target agonist Details Tecadenoson investigational yes target agonist Details Defibrotide approved, investigational yes target Details Rolofylline investigational yes target antagonist Details Aminophylline approved yes target antagonist Details Theophylline approved yes target antagonist Details Tonapofylline investigational yes target inhibitor Details FK352B investigational yes target antagonist Details Adenosine approved, investigational yes target agonist Details Pentoxifylline approved, investigational unknown target Details Dyphylline approved yes target antagonist Details Oxtriphylline approved yes target antagonist Details Theobromine investigational yes target antagonist Details Enprofylline approved, experimental unknown target inhibitor Details Naxifylline investigational unknown target antagonist Details Lamotrigine approved, investigational unknown target inhibitor Details Cannabidiol approved, investigational unknown target activator Details Tramadol approved, investigational yes target agonist Details Istradefylline approved, investigational no target antagonist Details Peoniflorin investigational yes target modulator Details Sakuranetin experimental yes target antagonist Details 3-isobutyl-1-methyl-7H-xanthine experimental yes target antagonist Details Flavone approved, experimental yes target antagonist Details DPCPX investigational yes target inhibitor Details 5'-S-methyl-5'-thioadenosine experimental yes target inhibitor Details GW-493838 investigational yes target modulator Details Trabodenoson investigational yes target agonist Details Derenofylline investigational yes target antagonist Details Selodenoson investigational yes target agonist Details Capadenoson investigational yes target agonist Details Neladenoson bialanate investigational yes target agonist Details 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol experimental yes target inhibitor Details