Adenosine receptor A1

Details

Name
Adenosine receptor A1
Synonyms
Not Available
Gene Name
ADORA1
UniProtKB Entry
P30542Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0000026|Adenosine receptor A1
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
Number of residues
326
Molecular Weight
36511.325
Theoretical pI
8.75
GO Classification
Functions
G protein-coupled adenosine receptor activity / G protein-coupled receptor binding / G-protein beta/gamma-subunit complex binding / heat shock protein binding / heterotrimeric G-protein binding / protein heterodimerization activity
Processes
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / fatty acid homeostasis / G protein-coupled receptor signaling pathway / leukocyte migration / long-term synaptic depression / mucus secretion / negative regulation of cell population proliferation / negative regulation of long-term synaptic depression / negative regulation of long-term synaptic potentiation / negative regulation of systemic arterial blood pressure / positive regulation of lipid catabolic process / positive regulation of MAPK cascade / positive regulation of systemic arterial blood pressure / regulation of cardiac muscle cell contraction / regulation of presynaptic cytosolic calcium ion concentration / regulation of respiratory gaseous exchange by nervous system process / response to purine-containing compound / triglyceride homeostasis / vasodilation
Components
calyx of Held / dendrite / synapse
General Function
Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase
Specific Function
G protein-coupled adenosine receptor activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
11-33 47-69 81-102 124-146 177-201 236-259 268-292
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010133|Adenosine receptor A1 (ADORA1)
ATGCCGCCCTCCATCTCAGCTTTCCAGGCCGCCTACATCGGCATCGAGGTGCTCATCGCC
CTGGTCTCTGTGCCCGGGAACGTGCTGGTGATCTGGGCGGTGAAGGTGAACCAGGCGCTG
CGGGATGCCACCTTCTGCTTCATCGTGTCGCTGGCGGTGGCTGATGTGGCCGTGGGTGCC
CTGGTCATCCCCCTCGCCATCCTCATCAACATTGGGCCACAGACCTACTTCCACACCTGC
CTCATGGTTGCCTGTCCGGTCCTCATCCTCACCCAGAGCTCCATCCTGGCCCTGCTGGCA
ATTGCTGTGGACCGCTACCTCCGGGTCAAGATCCCTCTCCGGTACAAGATGGTGGTGACC
CCCCGGAGGGCGGCGGTGGCCATAGCCGGCTGCTGGATCCTCTCCTTCGTGGTGGGACTG
ACCCCTATGTTTGGCTGGAACAATCTGAGTGCGGTGGAGCGGGCCTGGGCAGCCAACGGC
AGCATGGGGGAGCCCGTGATCAAGTGCGAGTTCGAGAAGGTCATCAGCATGGAGTACATG
GTCTACTTCAACTTCTTTGTGTGGGTGCTGCCCCCGCTTCTCCTCATGGTCCTCATCTAC
CTGGAGGTCTTCTACCTAATCCGCAAGCAGCTCAACAAGAAGGTGTCGGCCTCCTCCGGC
GACCCGCAGAAGTACTATGGGAAGGAGCTGAAGATCGCCAAGTCGCTGGCCCTCATCCTC
TTCCTCTTTGCCCTCAGCTGGCTGCCTTTGCACATCCTCAACTGCATCACCCTCTTCTGC
CCGTCCTGCCACAAGCCCAGCATCCTTACCTACATTGCCATCTTCCTCACGCACGGCAAC
TCGGCCATGAACCCCATTGTCTATGCCTTCCGCATCCAGAAGTTCCGCGTCACCTTCCTT
AAGATTTGGAATGACCATTTCCGCTGCCAGCCTGCACCTCCCATTGACGAGGATCTCCCA
GAAGAGAGGCCTGATGACTAG
Chromosome Location
1
Locus
1q32.1
External Identifiers
ResourceLink
UniProtKB IDP30542
UniProtKB Entry NameAA1R_HUMAN
GenBank Protein ID256155
GenBank Gene IDS45235
GeneCard IDADORA1
GenAtlas IDADORA1
HGNC IDHGNC:262
PDB ID(s)5N2S, 5UEN, 6D9H, 7LD3, 7LD4
KEGG IDhsa:134
IUPHAR/Guide To Pharmacology ID18
NCBI Gene ID134
General References
  1. Libert F, Van Sande J, Lefort A, Czernilofsky A, Dumont JE, Vassart G, Ensinger HA, Mendla KD: Cloning and functional characterization of a human A1 adenosine receptor. Biochem Biophys Res Commun. 1992 Sep 16;187(2):919-26. [Article]
  2. Townsend-Nicholson A, Shine J: Molecular cloning and characterisation of a human brain A1 adenosine receptor cDNA. Brain Res Mol Brain Res. 1992 Dec;16(3-4):365-70. [Article]
  3. Ren H, Stiles GL: Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing. J Biol Chem. 1994 Jan 28;269(4):3104-10. [Article]
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Associated Data

Bio-Entities
Bio-EntityType
Adenosine receptor A1 (Humans)protein
primary
Adenosine receptor (Humans)protein
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
CaffeineapprovedyestargetantagonistDetails
Gabapentinapproved, investigationalunknowntargetagonistDetails
TecadenosoninvestigationalyestargetagonistDetails
Defibrotideapproved, investigationalyestargetDetails
RolofyllineinvestigationalyestargetantagonistDetails
AminophyllineapprovedyestargetantagonistDetails
TheophyllineapprovedyestargetantagonistDetails
TonapofyllineinvestigationalyestargetinhibitorDetails
FK352BinvestigationalyestargetantagonistDetails
Adenosineapproved, investigationalyestargetagonistDetails
Pentoxifyllineapproved, investigationalunknowntargetDetails
DyphyllineapprovedyestargetantagonistDetails
OxtriphyllineapprovedyestargetantagonistDetails
TheobromineinvestigationalyestargetantagonistDetails
Enprofyllineapproved, experimentalunknowntargetinhibitorDetails
NaxifyllineinvestigationalunknowntargetantagonistDetails
Lamotrigineapproved, investigationalunknowntargetinhibitorDetails
Cannabidiolapproved, investigationalunknowntargetactivatorDetails
Tramadolapproved, investigationalyestargetagonistDetails
Istradefyllineapproved, investigationalnotargetantagonistDetails
PeoniflorininvestigationalyestargetmodulatorDetails
SakuranetinexperimentalyestargetantagonistDetails
3-isobutyl-1-methyl-7H-xanthineexperimentalyestargetantagonistDetails
Flavoneapproved, experimentalyestargetantagonistDetails
DPCPXinvestigationalyestargetinhibitorDetails
5'-S-methyl-5'-thioadenosineexperimentalyestargetinhibitorDetails
GW-493838investigationalyestargetmodulatorDetails
TrabodenosoninvestigationalyestargetagonistDetails
DerenofyllineinvestigationalyestargetantagonistDetails
SelodenosoninvestigationalyestargetagonistDetails
CapadenosoninvestigationalyestargetagonistDetails
Neladenoson bialanateinvestigationalyestargetagonistDetails
4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenolexperimentalyestargetinhibitorDetails