Alpha-1B adrenergic receptor
Details
- Name
- Alpha-1B adrenergic receptor
- Synonyms
- Alpha-1B adrenoceptor
- Alpha-1B adrenoreceptor
- Gene Name
- ADRA1B
- UniProtKB Entry
- P35368Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0010399|Alpha-1B adrenergic receptor MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAI VGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDI WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFV RILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRT LPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLT EPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
- Number of residues
- 520
- Molecular Weight
- 56835.375
- Theoretical pI
- 9.79
- GO Classification
- Processesadenylate cyclase-modulating G protein-coupled receptor signaling pathway / G protein-coupled receptor signaling pathway / neuron-glial cell signaling / phospholipase C-activating G protein-coupled receptor signaling pathway / regulation of vasoconstrictionComponentscaveola / cytoplasm
- General Function
- This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes
- Specific Function
- Alpha1-adrenergic receptor activity
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 46-70 84-105 116-141 162-184 202-224 296-319 327-351
- Cellular Location
- Nucleus membrane
- Gene sequence
>lcl|BSEQ0010400|Alpha-1B adrenergic receptor (ADRA1B) ATGAATCCCGACCTGGACACCGGCCACAACACATCAGCACCTGCCCACTGGGGAGAGTTG AAAAATGCCAACTTCACTGGCCCCAACCAGACCTCGAGCAACTCCACACTGCCCCAGCTG GACATCACCAGGGCCATCTCTGTGGGCCTGGTGCTGGGCGCCTTCATCCTCTTTGCCATC GTGGGCAACATCCTAGTCATCTTGTCTGTGGCCTGCAACCGGCACCTGCGGACGCCCACC AACTACTTCATTGTCAACCTGGCCATGGCCGACCTGCTGTTGAGCTTCACCGTCCTGCCC TTCTCAGCGGCCCTAGAGGTGCTCGGCTACTGGGTGCTGGGGCGGATCTTCTGTGACATC TGGGCAGCCGTGGATGTCCTGTGCTGCACAGCGTCCATTCTGAGCCTGTGCGCCATCTCC ATCGATCGCTACATCGGGGTGCGCTACTCTCTGCAGTATCCCACGCTGGTCACCCGGAGG AAGGCCATCTTGGCGCTGCTCAGTGTCTGGGTCTTGTCCACCGTCATCTCCATCGGGCCT CTCCTTGGGTGGAAGGAGCCGGCACCCAACGATGACAAGGAGTGCGGGGTCACCGAAGAA CCCTTCTATGCCCTCTTCTCCTCTCTGGGCTCCTTCTACATCCCTCTGGCGGTCATTCTA GTCATGTACTGCCGTGTCTATATAGTGGCCAAGAGAACCACCAAGAACCTAGAGGCAGGA GTCATGAAGGAGATGTCCAACTCCAAGGAGCTGACCCTGAGGATCCATTCCAAGAACTTT CACGAGGACACCCTTAGCAGTACCAAGGCCAAGGGCCACAACCCCAGGAGTTCCATAGCT GTCAAACTTTTTAAGTTCTCCAGGGAAAAGAAAGCAGCTAAGACGTTGGGCATTGTGGTC GGTATGTTCATCTTGTGCTGGCTACCCTTCTTCATCGCTCTACCGCTTGGCTCCTTGTTC TCCACCCTGAAGCCCCCCGACGCCGTGTTCAAGGTGGTGTTCTGGCTGGGCTACTTCAAC AGCTGCCTCAACCCCATCATCTACCCATGCTCCAGCAAGGAGTTCAAGCGCGCTTTCGTG CGCATCCTCGGGTGCCAGTGCCGCGGCCGCGGCCGCCGCCGACGCCGCCGCCGCCGTCGC CTGGGCGGCTGCGCCTACACCTACCGGCCGTGGACGCGCGGCGGCTCGCTGGAGCGCTCG CAGTCGCGCAAGGACTCGCTGGACGACAGCGGCAGCTGCCTGAGCGGCAGCCAGCGGACC CTGCCCTCGGCCTCGCCGAGCCCGGGCTACCTGGGCCGCGGCGCGCCACCGCCAGTCGAG CTGTGCGCCTTCCCCGAGTGGAAGGCGCCCGGCGCCCTCCTGAGCCTGCCCGCGCCTGAG CCCCCCGGCCGCCGCGGCCGCCACGACTCGGGCCCGCTCTTCACCTTCAAGCTCCTGACC GAGCCCGAGAGCCCCGGGACCGACGGCGGCGCCAGCAACGGAGGCTGCGAGGCCGCGGCC GACGTGGCCAACGGGCAGCCGGGCTTCAAAAGCAACATGCCCCTGGCGCCCGGGCAGTTT TAG
- Chromosome Location
- 5
- Locus
- 5q33.3
- External Identifiers
Resource Link UniProtKB ID P35368 UniProtKB Entry Name ADA1B_HUMAN GenBank Gene ID M99589 GeneCard ID ADRA1B GenAtlas ID ADRA1B HGNC ID HGNC:278 KEGG ID hsa:147 IUPHAR/Guide To Pharmacology ID 23 NCBI Gene ID 147 - General References
- Ramarao CS, Denker JM, Perez DM, Gaivin RJ, Riek RP, Graham RM: Genomic organization and expression of the human alpha 1B-adrenergic receptor. J Biol Chem. 1992 Oct 25;267(30):21936-45. [Article]
- Forray C, Bard JA, Wetzel JM, Chiu G, Shapiro E, Tang R, Lepor H, Hartig PR, Weinshank RL, Branchek TA, et al.: The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. Mol Pharmacol. 1994 Apr;45(4):703-8. [Article]
- Schwinn DA, Johnston GI, Page SO, Mosley MJ, Wilson KH, Worman NP, Campbell S, Fidock MD, Furness LM, Parry-Smith DJ, et al.: Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J Pharmacol Exp Ther. 1995 Jan;272(1):134-42. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Wright CD, Chen Q, Baye NL, Huang Y, Healy CL, Kasinathan S, O'Connell TD: Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes. Circ Res. 2008 Oct 24;103(9):992-1000. doi: 10.1161/CIRCRESAHA.108.176024. Epub 2008 Sep 18. [Article]
- Wright CD, Wu SC, Dahl EF, Sazama AJ, O'Connell TD: Nuclear localization drives alpha1-adrenergic receptor oligomerization and signaling in cardiac myocytes. Cell Signal. 2012 Mar;24(3):794-802. doi: 10.1016/j.cellsig.2011.11.014. Epub 2011 Nov 18. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Alpha-1B adrenergic receptor (Humans) protein primaryAlpha-1 adrenergic receptors (Humans) protein Alpha adrenergic receptor (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Dapiprazole approved yes target antagonist Details Tamsulosin approved, investigational unknown target antagonist Details Modafinil approved, investigational unknown target partial agonist Details Terazosin approved yes target antagonist Details Methotrimeprazine approved, investigational unknown target antagonist Details Prazosin approved yes target antagonist Details Methoxamine approved, investigational unknown target agonist Details Periciazine approved, investigational unknown target antagonist Details Dextroamphetamine approved, illicit unknown target antagonist Details Phendimetrazine approved, illicit unknown target agonist Details Norepinephrine approved yes target agonist Details Midodrine approved yes target agonist Details Nefazodone approved, withdrawn unknown target other/unknown Details Olanzapine approved, investigational unknown target antagonist Details Phenylephrine approved yes target agonist Details Alfuzosin approved, investigational yes target antagonist Details Dronedarone approved yes target antagonist Details Sertindole approved, investigational, withdrawn unknown target Details R450 investigational unknown target Details Epicept NP-1 investigational unknown target Details Droxidopa approved, investigational yes target agonist Details Ocaperidone investigational unknown target Details Pergolide approved, investigational, vet_approved, withdrawn unknown target agonist Details Bromocriptine approved, investigational, withdrawn unknown target antagonistagonist Details Nicardipine approved, investigational unknown target antagonist Details Paliperidone approved unknown target antagonist Details Ziprasidone approved unknown target antagonist Details Clozapine approved no target antagonist Details Aripiprazole approved, investigational no target antagonist Details Trimipramine approved unknown target antagonist Details Ergotamine approved yes target partial agonist Details Doxepin approved, investigational unknown target antagonist Details Chlorpromazine approved, investigational, vet_approved yes target antagonist Details Thioridazine approved, withdrawn yes target antagonist Details Acepromazine experimental, vet_approved unknown target antagonist Details Thioproperazine experimental yes target antagonist Details Xylometazoline approved, investigational unknown target agonist Details Epinephrine approved, vet_approved yes target agonist Details Silodosin approved yes target antagonist Details Loxapine approved unknown target binder Details Imipramine approved unknown target antagonist Details Carvedilol approved, investigational unknown target antagonist Details Clonidine approved unknown target agonist Details Nortriptyline approved unknown target antagonist Details Fenoldopam approved unknown target inhibitor Details Cabergoline approved unknown target binder Details Amitriptyline approved unknown target antagonist Details Phenoxybenzamine approved unknown target antagonist Details Oxymetazoline approved, investigational unknown target agonist Details Cirazoline experimental yes target partial agonist Details Brexpiprazole approved, investigational unknown target antagonist Details Quinidine approved, investigational unknown target antagonist Details Verapamil approved unknown target antagonist Details Racepinephrine approved yes target agonist Details Pizotifen approved unknown target antagonist Details Aripiprazole lauroxil approved, investigational no target antagonist Details Doxazosin approved unknown target Details Risperidone approved, investigational unknown target antagonist Details Viloxazine approved, investigational, withdrawn unknown target antagonist Details Clorotepine experimental yes target inhibitor Details Fluanisone experimental yes target inhibitor Details Levonordefrin approved yes target inhibitor Details Medetomidine experimental, vet_approved yes target inhibitor Details Metamfetamine approved, illicit, withdrawn yes target antagonist Details Siramesine investigational yes target inhibitor Details Labetalol approved yes target antagonist Details Maprotiline approved, investigational no target antagonist Details Quetiapine approved unknown target antagonist Details Desipramine approved, investigational no target antagonist Details Chlorpromazine approved, investigational, vet_approved unknown target inhibitor Details Mirtazapine approved unknown target antagonist Details Amoxapine approved unknown target antagonist Details Mianserin approved, investigational unknown target antagonist Details Tetryzoline approved yes target agonist Details Tiapride investigational yes target antagonist Details Perospirone experimental unknown target antagonist Details Dosulepin approved yes target antagonist Details Dobutamine approved yes target agonist Details Synephrine experimental unknown target Details Etoperidone withdrawn unknown target antagonist Details Lorpiprazole approved yes target antagonist Details Arotinolol investigational yes target antagonist Details Pipamperone investigational unknown target antagonist Details Ranolazine approved, investigational no target antagonist Details Prazosin approved unknown target Details Tizanidine approved, investigational unknown target agonist Details Prochlorperazine approved, vet_approved unknown target antagonist Details Buspirone approved, investigational unknown target partial agonist Details Paroxetine approved, investigational unknown target binder Details Escitalopram approved unknown target inhibitor Details Carvedilol approved, investigational yes target inhibitor Details Alfuzosin approved, investigational yes target antagonist Details Dihydroergotamine approved, investigational unknown target agonist Details Phentolamine approved yes target antagonist Details Mephentermine approved yes target agonist Details Amphetamine approved, illicit, investigational unknown target agonist Details Moxisylyte approved, investigational yes target antagonist Details Aranidipine experimental unknown target agonist Details Indigotindisulfonic acid approved, investigational no target agonist Details Dihydroergocristine approved, experimental yes target antagonistagonist Details Ergoloid mesylate approved yes target antagonistagonist Details Dihydroergocornine approved yes target antagonistagonist Details DL-Methylephedrine approved yes target agonist Details Ropinirole approved, investigational unknown target antagonist Details Promethazine approved, investigational unknown target antagonist Details Dextroamphetamine approved, illicit unknown target inhibitorinducer Details