Delta-type opioid receptor

Details

Name
Delta-type opioid receptor
Synonyms
  • D-OR-1
  • DOR-1
  • OPRD
Gene Name
OPRD1
UniProtKB Entry
P41143Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0010290|Delta-type opioid receptor
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
Number of residues
372
Molecular Weight
40368.235
Theoretical pI
9.17
GO Classification
Functions
neuropeptide binding
Processes
adult locomotory behavior / cellular response to growth factor stimulus / cellular response to hypoxia / cellular response to toxic substance / eating behavior / immune response / negative regulation of gene expression / neuropeptide signaling pathway / positive regulation of CREB transcription factor activity / positive regulation of peptidyl-serine phosphorylation / regulation of calcium ion transport / regulation of mitochondrial membrane potential
Components
axon terminus / dendrite membrane / neuron projection / plasma membrane
General Function
G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine
Specific Function
G protein-coupled enkephalin receptor activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
48-75 86-110 123-144 164-186 207-238 262-284 300-321
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010291|Delta-type opioid receptor (OPRD1)
ATGGAACCGGCCCCCTCCGCCGGCGCCGAGCTGCAGCCCCCGCTCTTCGCCAACGCCTCG
GACGCCTACCCTAGCGCCTGCCCCAGCGCTGGCGCCAATGCGTCGGGGCCGCCAGGCGCG
CGGAGCGCCTCGTCCCTCGCCCTGGCAATCGCCATCACCGCGCTCTACTCGGCCGTGTGC
GCCGTGGGGCTGCTGGGCAACGTGCTTGTCATGTTCGGCATCGTCCGGTACACTAAGATG
AAGACGGCCACCAACATCTACATCTTCAACCTGGCCTTAGCCGATGCGCTGGCCACCAGC
ACGCTGCCTTTCCAGAGTGCCAAGTACCTGATGGAGACGTGGCCCTTCGGCGAGCTGCTC
TGCAAGGCTGTGCTCTCCATCGACTACTACAATATGTTCACCAGCATCTTCACGCTCACC
ATGATGAGTGTTGACCGCTACATCGCTGTCTGCCACCCTGTCAAGGCCCTGGACTTCCGC
ACGCCTGCCAAGGCCAAGCTGATCAACATCTGTATCTGGGTCCTGGCCTCAGGCGTTGGC
GTGCCCATCATGGTCATGGCTGTGACCCGTCCCCGGGACGGGGCAGTGGTGTGCATGCTC
CAGTTCCCCAGCCCCAGCTGGTACTGGGACACGGTGACCAAGATCTGCGTGTTCCTCTTC
GCCTTCGTGGTGCCCATCCTCATCATCACCGTGTGCTATGGCCTCATGCTGCTGCGCCTG
CGCAGTGTGCGCCTGCTGTCGGGCTCCAAGGAGAAGGACCGCAGCCTGCGGCGCATCACG
CGCATGGTGCTGGTGGTTGTGGGCGCCTTCGTGGTGTGTTGGGCGCCCATCCACATCTTC
GTCATCGTCTGGACGCTGGTGGACATCGACCGGCGCGACCCGCTGGTGGTGGCTGCGCTG
CACCTGTGCATCGCGCTGGGCTACGCCAATAGCAGCCTCAACCCCGTGCTCTACGCTTTC
CTCGACGAGAACTTCAAGCGCTGCTTCCGCCAGCTCTGCCGCAAGCCCTGCGGCCGCCCA
GACCCCAGCAGCTTCAGCCGCGCCCGCGAAGCCACGGCCCGCGAGCGTGTCACCGCCTGC
ACCCCGTCCGATGGTCCCGGCGGTGGCGCTGCCGCCTGA
Chromosome Location
1
Locus
1p35.3
External Identifiers
ResourceLink
UniProtKB IDP41143
UniProtKB Entry NameOPRD_HUMAN
GenBank Protein ID27545517
GenBank Gene IDU07882
GeneCard IDOPRD1
GenAtlas IDOPRD1
HGNC IDHGNC:8153
PDB ID(s)4N6H, 4RWA, 4RWD, 6PT2, 6PT3, 8F7S
KEGG IDhsa:4985
IUPHAR/Guide To Pharmacology ID317
NCBI Gene ID4985
General References
  1. Knapp RJ, Malatynska E, Fang L, Li X, Babin E, Nguyen M, Santoro G, Varga EV, Hruby VJ, Roeske WR, et al.: Identification of a human delta opioid receptor: cloning and expression. Life Sci. 1994;54(25):PL463-9. [Article]
  2. Simonin F, Befort K, Gaveriaux-Ruff C, Matthes H, Nappey V, Lannes B, Micheletti G, Kieffer B: The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain. Mol Pharmacol. 1994 Dec;46(6):1015-21. [Article]
  3. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [Article]
  4. Whistler JL, Enquist J, Marley A, Fong J, Gladher F, Tsuruda P, Murray SR, Von Zastrow M: Modulation of postendocytic sorting of G protein-coupled receptors. Science. 2002 Jul 26;297(5581):615-20. [Article]
  5. Simonin F, Karcher P, Boeuf JJ, Matifas A, Kieffer BL: Identification of a novel family of G protein-coupled receptor associated sorting proteins. J Neurochem. 2004 May;89(3):766-75. [Article]
  6. Leskela TT, Lackman JJ, Vierimaa MM, Kobayashi H, Bouvier M, Petaja-Repo UE: Cys-27 variant of human delta-opioid receptor modulates maturation and cell surface delivery of Phe-27 variant via heteromerization. J Biol Chem. 2012 Feb 10;287(7):5008-20. doi: 10.1074/jbc.M111.305656. Epub 2011 Dec 19. [Article]
  7. Agirregoitia E, Peralta L, Mendoza R, Exposito A, Ereno ED, Matorras R, Agirregoitia N: Expression and localization of opioid receptors during the maturation of human oocytes. Reprod Biomed Online. 2012 May;24(5):550-7. doi: 10.1016/j.rbmo.2012.02.007. Epub 2012 Feb 22. [Article]
  8. Gelernter J, Kranzler HR: Variant detection at the delta opioid receptor (OPRD1) locus and population genetics of a novel variant affecting protein sequence. Hum Genet. 2000 Jul;107(1):86-8. [Article]
  9. Decaillot FM, Befort K, Filliol D, Yue S, Walker P, Kieffer BL: Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation. Nat Struct Biol. 2003 Aug;10(8):629-36. [Article]

Associated Data

Bio-Entities
Bio-EntityType
Delta-type opioid receptor (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Codeineapproved, illicityestargetagonistDetails
Hydromorphoneapproved, illicityestargetpartial agonistDetails
Dextropropoxypheneapproved, illicit, investigational, withdrawnyestargetagonistDetails
NalbuphineapprovedyestargetantagonistDetails
Hydrocodoneapproved, illicit, investigationalyestargetagonistDetails
Morphineapproved, investigationalyestargetagonistDetails
Butorphanolapproved, illicit, vet_approvedyestargetagonistDetails
Fentanylapproved, illicit, investigational, vet_approvedyestargetagonistDetails
Naloxoneapproved, vet_approvedyestargetantagonistDetails
Etorphineillicit, vet_approvedyestargetagonistDetails
Diprenorphineillicit, vet_approvedyestargetantagonistDetails
3-Methylthiofentanylexperimental, illicityestargetagonistDetails
Dimethylthiambuteneexperimental, illicityestargetagonistDetails
LoperamideapprovedunknowntargetagonistDetails
Naltrexoneapproved, investigational, vet_approvedyestargetantagonistDetails
3-MethylfentanylillicityestargetagonistDetails
ADL5859investigationalunknowntargetDetails
Oxycodoneapproved, illicit, investigationalyestargetagonistDetails
DPI-221investigationalunknowntargetDetails
TapentadolapprovedunknowntargetagonistDetails
Morphine glucuronideinvestigationalunknowntargetDetails
Diamorphineapproved, illicit, investigationalunknowntargetagonistDetails
Tramadolapproved, investigationalunknowntargetagonistDetails
MethadoneapprovedyestargetagonistDetails
Sufentanilapproved, investigationalunknowntargetagonistDetails
Carfentanilillicit, investigational, vet_approvedyestargetagonistDetails
Oxymorphoneapproved, investigational, vet_approvedunknowntargetantagonistDetails
AmitriptylineapprovedunknowntargetagonistDetails
Diphenoxylateapproved, illicitunknowntargetagonistDetails
LevorphanolapprovedunknowntargetagonistDetails
Dihydromorphineexperimental, illicityestargetagonistDetails
Buprenorphineapproved, illicit, investigational, vet_approvedunknowntargetantagonistDetails
Alvimopanapproved, investigationalunknowntargetantagonistDetails
RemifentanilapprovedunknowntargetagonistDetails
KetobemidoneinvestigationalyestargetagonistDetails
DextromethorphanapprovedunknowntargetagonistDetails
Ketamineapproved, vet_approvedunknowntargetbinderDetails
Eluxadolineapproved, investigationalyestargetantagonistDetails
Naldemedineapproved, investigationalyestargetantagonistDetails
Nalmefeneapproved, investigational, withdrawnyestargetantagonistDetails
Cannabidiolapproved, investigationalunknowntargetDetails
Pholcodineapproved, illicitunknowntargetantagonistDetails
Opiumapproved, illicityestargetagonistDetails
NabiximolsinvestigationalunknowntargetDetails
Medical Cannabisexperimental, investigationalunknowntargetDetails
LoxicodegolinvestigationalunknowntargetagonistDetails
ButyrfentanylillicitunknowntargetagonistDetails
Aripiprazoleapproved, investigationalunknowntargetligandDetails
MetenkefalininvestigationalyestargetagonistDetails
Amisulprideapproved, investigationalnotargetagonistDetails
Samidorphanapproved, investigationalunknowntargetpartial agonistDetails
DADLEexperimentalyestargetagonistDetails
Somatostatinapproved, investigationalyestargetinhibitorDetails
DPDPEexperimentalyestargetinhibitorDetails
LofentanilillicityestargetinhibitorDetails
DimepheptanolinvestigationalyestargetinhibitorDetails
Etonitazeneexperimental, illicityestargetinhibitorDetails
Salvinorin AinvestigationalyestargetinhibitorDetails
DynorphininvestigationalyestargetinhibitorDetails