P2Y purinoceptor 2
Details
- Name
- P2Y purinoceptor 2
- Synonyms
- ATP receptor
- P2RU1
- P2U purinoceptor 1
- P2U receptor 1
- P2U1
- P2Y2
- Purinergic receptor
- Gene Name
- P2RY2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0016779|P2Y purinoceptor 2 MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLC RLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCS ILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGR VTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAK RKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSC LDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSR RTESTPAGSENTKDIRL
- Number of residues
- 377
- Molecular Weight
- 42272.92
- Theoretical pI
- 9.88
- GO Classification
- FunctionsATP binding / G-protein coupled purinergic nucleotide receptor activity / receptor activity / UTP-activated nucleotide receptor activityProcessesaging / cellular ion homeostasis / cellular response to interleukin-1 / cellular response to lipopolysaccharide / cellular response to purine-containing compound / in utero embryonic development / negative regulation of ossification / phospholipase C-activating G-protein coupled receptor signaling pathway / positive regulation of chemokine production / positive regulation of cytosolic calcium ion concentration / positive regulation of mucus secretion / positive regulation of neuron projection development / positive regulation of penile erection / positive regulation of prostaglandin secretion / positive regulation of smooth muscle cell migration / regulation of vasodilation / response to growth factor / sensory perception of pain / wound healingComponentsapical plasma membrane / basolateral plasma membrane / cytosol / early endosome / integral component of plasma membrane / lysosome / mitochondrion / plasma membrane
- General Function
- Utp-activated nucleotide receptor activity
- Specific Function
- Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 33-59 71-93 111-129 153-172 195-220 247-269 288-309
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016780|P2Y purinoceptor 2 (P2RY2) ATGGCAGCAGACCTGGGCCCCTGGAATGACACCATCAATGGCACCTGGGATGGGGATGAG CTGGGCTACAGGTGCCGCTTCAACGAGGACTTCAAGTACGTGCTGCTGCCTGTGTCCTAC GGCGTGGTGTGCGTGCTTGGGCTGTGTCTGAACGCCGTGGCGCTCTACATCTTCTTGTGC CGCCTCAAGACCTGGAATGCGTCCACCACATATATGTTCCACCTGGCTGTGTCTGATGCA CTGTATGCGGCCTCCCTGCCGCTGCTGGTCTATTACTACGCCCGCGGCGACCACTGGCCC TTCAGCACGGTGCTCTGCAAGCTGGTGCGCTTCCTCTTCTACACCAACCTTTACTGCAGC ATCCTCTTCCTCACCTGCATCAGCGTGCACCGGTGTCTGGGCGTCTTACGACCTCTGCGC TCCCTGCGCTGGGGCCGGGCCCGCTACGCTCGCCGGGTGGCCGGGGCCGTGTGGGTGTTG GTGCTGGCCTGCCAGGCCCCCGTGCTCTACTTTGTCACCACCAGCGCGCGCGGGGGCCGC GTAACCTGCCACGACACCTCGGCACCCGAGCTCTTCAGCCGCTTCGTGGCCTACAGCTCA GTCATGCTGGGCCTGCTCTTCGCGGTGCCCTTTGCCGTCATCCTTGTCTGTTACGTGCTC ATGGCTCGGCGACTGCTAAAGCCAGCCTACGGGACCTCGGGCGGCCTGCCTAGGGCCAAG CGCAAGTCCGTGCGCACCATCGCCGTGGTGCTGGCTGTCTTCGCCCTCTGCTTCCTGCCA TTCCACGTCACCCGCACCCTCTACTACTCCTTCCGCTCGCTGGACCTCAGCTGCCACACC CTCAACGCCATCAACATGGCCTACAAGGTTACCCGGCCGCTGGCCAGTGCTAACAGTTGC CTTGACCCCGTGCTCTACTTCCTGGCTGGGCAGAGGCTCGTACGCTTTGCCCGAGATGCC AAGCCACCCACTGGCCCCAGCCCTGCCACCCCGGCTCGCCGCAGGCTGGGCCTGCGCAGA TCCGACAGAACTGACATGCAGAGGATAGAAGATGTGTTGGGCAGCAGTGAGGACTCTAGG CGGACAGAGTCCACGCCGGCTGGTAGCGAGAACACTAAGGACATTCGGCTGTAG
- Chromosome Location
- 11
- Locus
- 11q13.5-q14.1
- External Identifiers
Resource Link UniProtKB ID P41231 UniProtKB Entry Name P2RY2_HUMAN GenBank Gene ID U07225 GenAtlas ID P2RY2 HGNC ID HGNC:8541 - General References
- Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT: Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3275-9. [Article]
- Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT: Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):13067. [Article]
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