Glucagon-like peptide 1 receptor
Details
- Name
- Glucagon-like peptide 1 receptor
- Synonyms
- GLP-1 receptor
- Gene Name
- GLP1R
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010605|Glucagon-like peptide 1 receptor MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDL FCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPW RDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIH LNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAAN YYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRN SNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLL GTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERW RLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
- Number of residues
- 463
- Molecular Weight
- 53025.22
- Theoretical pI
- 8.19
- GO Classification
- Functionsglucagon receptor activity / transmembrane signaling receptor activityProcessesactivation of adenylate cyclase activity / cAMP-mediated signaling / cell surface receptor signaling pathway / energy reserve metabolic process / learning or memory / positive regulation of blood pressure / positive regulation of cytosolic calcium ion concentration / regulation of heart contraction / regulation of insulin secretion / response to stress / small molecule metabolic processComponentscytosol / integral component of membrane / intracellular / plasma membrane
- General Function
- Transmembrane signaling receptor activity
- Specific Function
- This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
- Pfam Domain Function
- Transmembrane Regions
- 140-164 177-201 228-251 266-287 306-328 353-371 384-404
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010606|Glucagon-like peptide 1 receptor (GLP1R) ATGGCCGGCGCCCCCGGCCCGCTGCGCCTTGCGCTGCTGCTGCTCGGGATGGTGGGCAGG GCCGGCCCCCGCCCCCAGGGTGCCACTGTGTCCCTCTGGGAGACGGTGCAGAAATGGCGA GAATACCGACGCCAGTGCCAGCGCTCCCTGACTGAGGATCCACCTCCTGCCACAGACTTG TTCTGCAACCGGACCTTCGATGAATACGCCTGCTGGCCAGATGGGGAGCCAGGCTCGTTC GTGAATGTCAGCTGCCCCTGGTACCTGCCCTGGGCCAGCAGTGTGCCGCAGGGCCACGTG TACCGGTTCTGCACAGCTGAAGGCCTCTGGCTGCAGAAGGACAACTCCAGCCTGCCCTGG AGGGACTTGTCGGAGTGCGAGGAGTCCAAGCGAGGGGAAAGAAGCTCCCCGGAGGAGCAG CTCCTGTTCCTCTACATCATCTACACGGTGGGCTACGCACTCTCCTTCTCTGCTCTGGTT ATCGCCTCTGCGATCCTCCTCGGCTTCAGACACCTGCACTGCACCAGGAACTACATCCAC CTGAACCTGTTTGCATCCTTCATCCTGCGAGCATTGTCCGTCTTCATCAAGGACGCAGCC CTGAAGTGGATGTATAGCACAGCCGCCCAGCAGCACCAGTGGGATGGGCTCCTCTCCTAC CAGGACTCTCTGAGCTGCCGCCTGGTGTTTCTGCTCATGCAGTACTGTGTGGCGGCCAAT TACTACTGGCTCTTGGTGGAGGGCGTGTACCTGTACACACTGCTGGCCTTCTCGGTCTTA TCTGAGCAATGGATCTTCAGGCTCTACGTGAGCATAGGCTGGGGTGTTCCCCTGCTGTTT GTTGTCCCCTGGGGCATTGTCAAGTACCTCTATGAGGACGAGGGCTGCTGGACCAGGAAC TCCAACATGAACTACTGGCTCATTATCCGGCTGCCCATTCTCTTTGCCATTGGGGTGAAC TTCCTCATCTTTGTTCGGGTCATCTGCATCGTGGTATCCAAACTGAAGGCCAATCTCATG TGCAAGACAGACATCAAATGCAGACTTGCCAAGTCCACGCTGACACTCATCCCCCTGCTG GGGACTCATGAGGTCATCTTTGCCTTTGTGATGGACGAGCACGCCCGGGGGACCCTGCGC TTCATCAAGCTGTTTACAGAGCTCTCCTTCACCTCCTTCCAGGGGCTGATGGTGGCCATA TTATACTGCTTTGTCAACAATGAGGTCCAGCTGGAATTTCGGAAGAGCTGGGAGCGCTGG CGGCTTGAGCACTTGCACATCCAGAGGGACAGCAGCATGAAGCCCCTCAAGTGTCCCACC AGCAGCCTGAGCAGTGGAGCCACGGCGGGCAGCAGCATGTACACAGCCACTTGCCAGGCC TCCTGCAGCTGA
- Chromosome Location
- 6
- Locus
- 6p21
- External Identifiers
Resource Link UniProtKB ID P43220 UniProtKB Entry Name GLP1R_HUMAN GenBank Protein ID 405082 GenBank Gene ID U01104 GenAtlas ID GLP1R HGNC ID HGNC:4324 - General References
- Thorens B, Porret A, Buhler L, Deng SP, Morel P, Widmann C: Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes. 1993 Nov;42(11):1678-82. [Article]
- Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, Yoo-Warren H, Permutt MA, Boyd AE 3rd: Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor. Endocrinology. 1993 Oct;133(4):1907-10. [Article]
- Graziano MP, Hey PJ, Borkowski D, Chicchi GG, Strader CD: Cloning and functional expression of a human glucagon-like peptide-1 receptor. Biochem Biophys Res Commun. 1993 Oct 15;196(1):141-6. [Article]
- van Eyll B, Lankat-Buttgereit B, Bode HP, Goke R, Goke B: Signal transduction of the GLP-1-receptor cloned from a human insulinoma. FEBS Lett. 1994 Jul 4;348(1):7-13. [Article]
- Wei Y, Mojsov S: Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences. FEBS Lett. 1995 Jan 30;358(3):219-24. [Article]
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- Lankat-Buttgereit B, Goke B: Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene. Peptides. 1997;18(5):617-24. [Article]
- Mann RJ, Al-Sabah S, de Maturana RL, Sinfield JK, Donnelly D: Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket. Peptides. 2010 Dec;31(12):2289-93. doi: 10.1016/j.peptides.2010.09.015. Epub 2010 Oct 1. [Article]
- Dezelak M, Bavec A: Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferase. Mol Biol Rep. 2012 Apr;39(4):4375-81. doi: 10.1007/s11033-011-1225-0. Epub 2011 Sep 8. [Article]
- Whitaker GM, Lynn FC, McIntosh CH, Accili EA: Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization. PLoS One. 2012;7(3):e32675. doi: 10.1371/journal.pone.0032675. Epub 2012 Mar 7. [Article]
- Runge S, Thogersen H, Madsen K, Lau J, Rudolph R: Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain. J Biol Chem. 2008 Apr 25;283(17):11340-7. doi: 10.1074/jbc.M708740200. Epub 2008 Feb 20. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01276 Exenatide approved, investigational yes agonist Details DB00040 Glucagon approved unknown agonist Details DB06655 Liraglutide approved yes agonist Details DB09043 Albiglutide approved yes agonist Details DB09045 Dulaglutide approved, investigational yes agonist Details DB09265 Lixisenatide approved yes agonist Details DB13928 Semaglutide approved, investigational yes agonist Details DB16697 Glutazumab investigational unknown agonist Details DB15171 Tirzepatide approved, investigational yes agonist Details DB15650 Efpeglenatide investigational unknown agonist Details DB14027 Taspoglutide investigational yes agonist Details