C-C chemokine receptor type 5

Details

Name
C-C chemokine receptor type 5
Synonyms
  • C-C CKR-5
  • CHEMR13
  • CMKBR5
  • HIV-1 fusion coreceptor
Gene Name
CCR5
Organism
Humans
Amino acid sequence
>lcl|BSEQ0016246|C-C chemokine receptor type 5
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
Number of residues
352
Molecular Weight
40523.645
Theoretical pI
9.18
GO Classification
Functions
actin binding / C-C chemokine binding / C-C chemokine receptor activity / chemokine (C-C motif) ligand 5 binding / chemokine receptor activity / coreceptor activity / phosphatidylinositol phospholipase C activity / virus receptor activity
Processes
calcium ion transport / calcium-mediated signaling / cell surface receptor signaling pathway / cell-cell signaling / cellular defense response / cellular response to lipopolysaccharide / chemokine-mediated signaling pathway / chemotaxis / dendritic cell chemotaxis / entry into host cell / G-protein coupled receptor signaling pathway / immune response / inflammatory response / MAPK cascade / positive regulation of cytosolic calcium ion concentration / release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / response to cholesterol / signaling / viral process
Components
cell surface / cytoplasm / cytosol / endosome / external side of plasma membrane / integral component of plasma membrane / plasma membrane
General Function
Virus receptor activity
Specific Function
Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.(Microbial infection) Acts as a receptor for human immunodeficiency virus-1/HIV-1.
Pfam Domain Function
Transmembrane Regions
31-58 69-89 103-124 142-166 199-218 236-260 278-301
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0016247|C-C chemokine receptor type 5 (CCR5)
ATGGATTATCAAGTGTCAAGTCCAATCTATGACATCAATTATTATACATCGGAGCCCTGC
CAAAAAATCAATGTGAAGCAAATCGCAGCCCGCCTCCTGCCTCCGCTCTACTCACTGGTG
TTCATCTTTGGTTTTGTGGGCAACATGCTGGTCATCCTCATCCTGATAAACTGCAAAAGG
CTGAAGAGCATGACTGACATCTACCTGCTCAACCTGGCCATCTCTGACCTGTTTTTCCTT
CTTACTGTCCCCTTCTGGGCTCACTATGCTGCCGCCCAGTGGGACTTTGGAAATACAATG
TGTCAACTCTTGACAGGGCTCTATTTTATAGGCTTCTTCTCTGGAATCTTCTTCATCATC
CTCCTGACAATCGATAGGTACCTGGCTGTCGTCCATGCTGTGTTTGCTTTAAAAGCCAGG
ACGGTCACCTTTGGGGTGGTGACAAGTGTGATCACTTGGGTGGTGGCTGTGTTTGCGTCT
CTCCCAGGAATCATCTTTACCAGATCTCAAAAAGAAGGTCTTCATTACACCTGCAGCTCT
CATTTTCCATACAGTCAGTATCAATTCTGGAAGAATTTCCAGACATTAAAGATAGTCATC
TTGGGGCTGGTCCTGCCGCTGCTTGTCATGGTCATCTGCTACTCGGGAATCCTAAAAACT
CTGCTTCGGTGTCGAAATGAGAAGAAGAGGCACAGGGCTGTGAGGCTTATCTTCACCATC
ATGATTGTTTATTTTCTCTTCTGGGCTCCCTACAACATTGTCCTTCTCCTGAACACCTTC
CAGGAATTCTTTGGCCTGAATAATTGCAGTAGCTCTAACAGGTTGGACCAAGCTATGCAG
GTGACAGAGACTCTTGGGATGACGCACTGCTGCATCAACCCCATCATCTATGCCTTTGTC
GGGGAGAAGTTCAGAAACTACCTCTTAGTCTTCTTCCAAAAGCACATTGCCAAACGCTTC
TGCAAATGCTGTTCTATTTTCCAGCAAGAGGCTCCCGAGCGAGCAAGCTCAGTTTACACC
CGATCCACTGGGGAGCAGGAAATATCTGTGGGCTTGTGA
Chromosome Location
3
Locus
3p21.31
External Identifiers
ResourceLink
UniProtKB IDP51681
UniProtKB Entry NameCCR5_HUMAN
GenBank Protein ID1262811
GenBank Gene IDX91492
GenAtlas IDCCR5
HGNC IDHGNC:1606
General References
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  11. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup RA, Moore JP, Paxton WA: HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature. 1996 Jun 20;381(6584):667-73. [PubMed:8649512]
  12. Samson M, Libert F, Doranz BJ, Rucker J, Liesnard C, Farber CM, Saragosti S, Lapoumeroulie C, Cognaux J, Forceille C, Muyldermans G, Verhofstede C, Burtonboy G, Georges M, Imai T, Rana S, Yi Y, Smyth RJ, Collman RG, Doms RW, Vassart G, Parmentier M: Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature. 1996 Aug 22;382(6593):722-5. [PubMed:8751444]
  13. Rizzuto CD, Wyatt R, Hernandez-Ramos N, Sun Y, Kwong PD, Hendrickson WA, Sodroski J: A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science. 1998 Jun 19;280(5371):1949-53. [PubMed:9632396]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04835Maravirocapproved, investigationalyesantagonistDetails
DB12960INCB-9471investigationalunknownDetails
DB05501AMD-070investigationalunknownDetails
DB05941LeronlimabinvestigationalunknownantagonistDetails
DB06497AplavirocinvestigationalunknownDetails
DB06652VicrivirocinvestigationalunknownDetails
DB12698Ibalizumabapproved, investigationalunknownantagonistDetails
DB05906CCR5 mAbinvestigationalunknownDetails