Monocarboxylate transporter 1

Details

Name
Monocarboxylate transporter 1
Synonyms
  • MCT 1
  • MCT1
  • Solute carrier family 16 member 1
Gene Name
SLC16A1
UniProtKB Entry
P53985Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0037057|Monocarboxylate transporter 1
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSW
ISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIG
GLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLI
LGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQ
EKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAF
LLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYA
GFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYK
YTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKA
AESPDQKDTDGGPKEEESPV
Number of residues
500
Molecular Weight
53943.685
Theoretical pI
8.82
GO Classification
Functions
carboxylic acid transmembrane transporter activity / identical protein binding / lactate / succinate transmembrane transporter activity
Processes
carboxylic acid transmembrane transport / centrosome cycle / pyruvate catabolic process / pyruvate transmembrane transport / succinate transmembrane transport / transport across blood-brain barrier
Components
apical plasma membrane / basal plasma membrane / basolateral plasma membrane / cell junction / intracellular membrane-bounded organelle / lateral plasma membrane / synapse
General Function
Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023)
Specific Function
carboxylic acid transmembrane transporter activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
23-44 56-80 85-105 110-132 147-169 175-194 262-288 296-317 329-349 354-375 390-410 422-443
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010466|Monocarboxylate transporter 1 (SLC16A1)
ATGCCACCAGCAGTTGGAGGTCCAGTTGGATACACCCCCCCAGATGGAGGCTGGGGCTGG
GCAGTGGTAATTGGAGCTTTCATTTCCATCGGCTTCTCTTATGCATTTCCCAAATCAATT
ACTGTCTTCTTCAAAGAGATTGAAGGTATATTCCATGCCACCACCAGCGAAGTGTCATGG
ATATCCTCCATAATGTTGGCTGTCATGTATGGTGGAGGTCCTATCAGCAGTATCCTGGTG
AATAAATATGGAAGTCGTATAGTCATGATTGTTGGTGGCTGCTTGTCAGGCTGTGGCTTG
ATTGCAGCTTCTTTCTGTAACACCGTACAGCAACTATACGTCTGTATTGGAGTCATTGGA
GGTCTTGGGCTTGCCTTCAACTTGAATCCAGCTCTGACCATGATTGGCAAGTATTTCTAC
AAGAGGCGACCATTGGCCAACGGACTGGCCATGGCAGGCAGCCCTGTGTTCCTCTGTACT
CTGGCCCCCCTCAATCAGGTTTTCTTCGGTATCTTTGGATGGAGAGGAAGCTTTCTAATT
CTTGGGGGCTTGCTACTAAACTGCTGTGTTGCTGGAGCCCTCATGCGACCAATCGGGCCC
AAGCCAACCAAGGCAGGGAAAGATAAGTCTAAAGCATCCCTTGAGAAAGCTGGAAAATCT
GGTGTGAAAAAAGATCTGCATGATGCAAATACAGATCTTATTGGAAGACACCCTAAACAA
GAGAAACGATCAGTCTTCCAAACAATTAATCAGTTCCTGGACTTAACCCTATTCACCCAC
AGAGGCTTTTTGCTATACCTCTCTGGAAATGTGATCATGTTTTTTGGACTCTTTGCACCT
TTGGTGTTTCTTAGTAGTTATGGGAAGAGTCAGCATTATTCTAGTGAGAAGTCTGCCTTC
CTTCTTTCCATTCTGGCTTTTGTTGACATGGTAGCCCGACCATCTATGGGACTTGTAGCC
AACACAAAGCCAATAAGACCTCGAATTCAGTATTTCTTTGCGGCTTCCGTTGTTGCAAAT
GGAGTGTGTCATATGCTAGCACCTTTATCCACTACCTATGTTGGATTCTGTGTCTATGCG
GGATTCTTTGGATTTGCCTTCGGGTGGCTCAGCTCCGTATTGTTTGAAACATTGATGGAC
CTTGTTGGACCCCAGAGGTTCTCCAGCGCTGTGGGATTGGTGACCATTGTGGAATGCTGT
CCTGTCCTCCTGGGGCCACCACTTTTAGGTCGGCTCAATGACATGTATGGAGACTACAAA
TACACATACTGGGCATGTGGCGTCGTCCTAATTATTTCAGGTATCTATCTCTTCATTGGC
ATGGGCATCAATTATCGACTTTTGGCAAAAGAACAGAAAGCAAACGAGCAGAAAAAGGAA
AGTAAAGAGGAAGAGACCAGTATAGATGTTGCTGGGAAGCCAAATGAAGTTACCAAAGCA
GCAGAATCTCCGGACCAGAAAGACACAGATGGAGGGCCCAAGGAGGAGGAAAGTCCAGTC
TGA
Chromosome Location
1
Locus
1p13.2
External Identifiers
ResourceLink
UniProtKB IDP53985
UniProtKB Entry NameMOT1_HUMAN
GenBank Protein ID561722
GenBank Gene IDL31801
GeneCard IDSLC16A1
GenAtlas IDSLC16A1
HGNC IDHGNC:10922
PDB ID(s)6LYY, 6LZ0, 7CKO, 7CKR, 7DA5, 7YR5
KEGG IDhsa:6566
IUPHAR/Guide To Pharmacology ID988
NCBI Gene ID6566
General References
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Associated Data

Bio-Entities
Bio-EntityType
Monocarboxylate transporter 1 (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Pyruvic acidapproved, investigational, nutraceuticalunknowntargetDetails
gamma-Hydroxybutyric acidapproved, illicit, investigationalunknowntransporterinhibitorDetails
D-Lactic acidexperimentalunknowntransportersubstrateinhibitorDetails
Lactic acidapproved, vet_approvedunknowntransportersubstrateinhibitorDetails
alpha-D-quinovopyranoseexperimentalunknowntransporterinhibitorDetails
Quercetinexperimental, investigationalunknowntransporterinhibitorDetails
Probenecidapproved, investigationalunknowntransporterinhibitorDetails
Niflumic acidexperimentalunknowntransporterinhibitorDetails
Acetoacetic acidexperimentalunknowntransportersubstrateinhibitorDetails
Pyruvic acidapproved, investigational, nutraceuticalunknowntransportersubstrateinhibitorDetails
alpha-KetoisovalerateexperimentalunknowntransporterinhibitorDetails
Nateglinideapproved, investigationalunknowntransportersubstrateDetails
Taurocholic acidapproved, experimentalunknowntransportersubstrateDetails
Salicylic acidapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Niacinapproved, investigational, nutraceuticalunknowntransportersubstrateDetails
MethotrexateapprovedunknowntransportersubstrateDetails
Glutamic acidapproved, nutraceuticalunknowntransportersubstrateDetails
FoscarnetapprovedunknowntransportersubstrateDetails
Aminohippuric acidapproved, investigationalunknowntransportersubstrateDetails
Acetic acidapprovedunknowntransportersubstrateDetails
Valproic acidapproved, investigationalunknowntransportersubstrateDetails
Ampicillinapproved, vet_approvedunknowntransporterDetails
PravastatinapprovednotransportersubstrateDetails
Benzoic acidapproved, investigationalunknowntransporterDetails
Arbaclofen PlacarbilinvestigationalunknowntransportersubstrateDetails
MersalylexperimentalunknowntargetantagonistDetails
Ferulic acidexperimentalnotransportersubstrateDetails