P2X purinoceptor 3
Details
- Name
- P2X purinoceptor 3
- Synonyms
- ATP receptor
- P2X3
- Purinergic receptor
- Gene Name
- P2RX3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052219|P2X purinoceptor 3 MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSV VTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDS QCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIR FPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLG IKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEE VNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
- Number of residues
- 397
- Molecular Weight
- 44288.65
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / extracellularly ATP-gated cation channel activity / purinergic nucleotide receptor activityProcessesbehavioral response to formalin induced pain / blood coagulation / cellular response to ATP / monovalent inorganic cation transport / neuromuscular synaptic transmission / neuronal action potential / peristalsis / positive regulation of calcium ion transport into cytosol / positive regulation of calcium-mediated signaling / positive regulation of sensory perception of pain / protein homotrimerization / regulation of synaptic plasticity / response to carbohydrate / response to cold / response to heat / response to hypoxia / response to mechanical stimulus / sensory perception of taste / signal transduction / urinary bladder smooth muscle contractionComponentscell / dendritic spine / Golgi apparatus / hippocampal mossy fiber to CA3 synapse / integral component of nuclear inner membrane / integral component of plasma membrane / integral component of presynaptic membrane / membrane raft / neuronal cell body / plasma membrane / receptor complex / rough endoplasmic reticulum / Schaffer collateral - CA1 synapse / terminal bouton
- General Function
- Receptor for ATP that acts as a ligand-gated cation channel (PubMed:27626375). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception (By similarity).
- Specific Function
- Atp binding
- Pfam Domain Function
- Not Available
- Transmembrane Regions
- 21-43 323-341
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052220|P2X purinoceptor 3 (P2RX3) ATGAACTGCATATCCGACTTCTTCACCTATGAGACCACCAAGTCGGTGGTTGTGAAGAGC TGGACCATCGGGATCATCAACCGAGTAGTTCAGCTTCTGATCATCTCCTACTTTGTAGGG TGGGTTTTCTTGCACGAGAAGGCTTACCAGGTACGGGACACAGCCATTGAGTCCTCGGTG GTAACCAAGGTGAAGGGCTCCGGACTCTACGCCAACAGAGTCATGGATGTGTCTGATTAC GTGACGCCACCTCAGGGCACCTCGGTCTTTGTCATCATCACCAAGATGATTGTTACTGAA AATCAGATGCAAGGATTCTGCCCAGAGAGTGAGGAGAAATACCGCTGTGTATCAGACAGC CAGTGCGGGCCTGAGCGCTTGCCAGGTGGGGGGATCCTCACTGGCCGCTGCGTGAACTAC AGCTCTGTGCTCCGGACCTGTGAGATCCAGGGCTGGTGCCCCACGGAGGTGGACACAGTG GAAACGCCCATCATGATGGAAGCTGAGAACTTCACTATTTTCATCAAGAACAGCATCCGT TTCCCCCTCTTCAACTTTGAGAAGGGAAACCTCCTTCCCAACCTGACAGCCAGGGACATG AAGACCTGCCGCTTCCACCCGGACAAGGACCCTTTCTGCCCCATCTTGCGGGTAGGGGAC GTGGTCAAGTTTGCGGGGCAGGATTTTGCCAAACTGGCGCGCACGGGGGGAGTTCTGGGC ATTAAGATCGGCTGGGTGTGCGACTTGGACAAGGCCTGGGACCAGTGCATCCCCAAATAC TCCTTCACCCGGCTCGACAGCGTTTCTGAGAAAAGCAGCGTGTCCCCAGGCTACAACTTC AGGTTTGCCAAGTACTACAAAATGGAAAATGGCAGTGAGTACCGCACCCTCCTGAAGGCT TTTGGCATCCGCTTCGACGTGCTGGTATACGGGAATGCTGGCAAGTTCAACATCATCCCC ACCATCATCAGCTCTGTGGCGGCCTTTACTTCTGTGGGAGTGGGAACTGTTCTCTGTGAC ATCATCCTGCTCAACTTCCTCAAGGGGGCCGACCAGTACAAAGCCAAGAAGTTTGAGGAG GTGAATGAGACTACGCTGAAAATCGCGGCTTTGACCAACCCAGTGTACCCCAGCGACCAG ACCACAGCGGAGAAGCAGTCCACCGATTCGGGGGCCTTCTCCATAGGCCACTAG
- Chromosome Location
- 11
- Locus
- 11q12.1
- External Identifiers
Resource Link UniProtKB ID P56373 UniProtKB Entry Name P2RX3_HUMAN HGNC ID HGNC:8534 - General References
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- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
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- Mansoor SE, Lu W, Oosterheert W, Shekhar M, Tajkhorshid E, Gouaux E: X-ray structures define human P2X(3) receptor gating cycle and antagonist action. Nature. 2016 Oct 6;538(7623):66-71. doi: 10.1038/nature19367. Epub 2016 Sep 14. [Article]