Transforming protein RhoA

Details

Name
Transforming protein RhoA
Synonyms
  • ARH12
  • ARHA
  • h12
  • Rho cDNA clone 12
  • RHO12
Gene Name
RHOA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0021661|Transforming protein RhoA
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDT
AGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKD
LRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQ
ARRGKKKSGCLVL
Number of residues
193
Molecular Weight
21767.94
Theoretical pI
5.89
GO Classification
Functions
GDP binding / GTP binding / GTPase activity / myosin binding
Processes
actin cytoskeleton organization / alpha-beta T cell lineage commitment / androgen receptor signaling pathway / apical junction assembly / apolipoprotein A-I-mediated signaling pathway / axon guidance / beta selection / blood coagulation / cell-matrix adhesion / cerebral cortex cell migration / cleavage furrow formation / ephrin receptor signaling pathway / forebrain radial glial cell differentiation / mitotic spindle assembly / negative chemotaxis / negative regulation of axonogenesis / negative regulation of I-kappaB kinase/NF-kappaB signaling / negative regulation of intracellular steroid hormone receptor signaling pathway / negative regulation of neuron apoptotic process / negative regulation of oxidative phosphorylation / negative regulation of reactive oxygen species biosynthetic process / neurotrophin TRK receptor signaling pathway / ossification involved in bone maturation / phosphatidylinositol-mediated signaling / platelet activation / positive regulation of actin filament polymerization / positive regulation of alpha-beta T cell differentiation / positive regulation of axonogenesis / positive regulation of cell growth / positive regulation of cell migration / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of cytokinesis / positive regulation of I-kappaB kinase/NF-kappaB signaling / positive regulation of lipase activity / positive regulation of neuron apoptotic process / positive regulation of neuron differentiation / positive regulation of NF-kappaB import into nucleus / positive regulation of podosome assembly / positive regulation of smooth muscle contraction / positive regulation of stress fiber assembly / positive regulation of translation / positive regulation of vasoconstriction / regulation of actin cytoskeleton organization / regulation of axonogenesis / regulation of calcium ion transport / regulation of cell migration / regulation of dendrite development / regulation of microtubule cytoskeleton organization / regulation of neural precursor cell proliferation / regulation of osteoblast proliferation / regulation of small GTPase mediated signal transduction / regulation of transcription from RNA polymerase II promoter / response to amino acid / response to drug / response to ethanol / response to glucocorticoid / response to glucose / response to hypoxia / response to mechanical stimulus / Rho protein signal transduction / skeletal muscle satellite cell migration / skeletal muscle tissue development / small GTPase mediated signal transduction / stress fiber assembly / stress-activated protein kinase signaling cascade / substantia nigra development / trabecula morphogenesis / transforming growth factor beta receptor signaling pathway / vascular endothelial growth factor receptor signaling pathway / viral process / wound healing, spreading of cells
Components
apical junction complex / axon / cell cortex / cell junction / cell periphery / cleavage furrow / cytoskeleton / cytosol / endoplasmic reticulum membrane / endosome / extracellular exosome / focal adhesion / lamellipodium / midbody / mitochondrion / nucleus / plasma membrane / ruffle membrane / vesicle
General Function
Myosin binding
Specific Function
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695).(Microbial infection) Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0021662|Transforming protein RhoA (RHOA)
ATGGCTGCCATCCGGAAGAAACTGGTGATTGTTGGTGATGGAGCCTGTGGAAAGACATGC
TTGCTCATAGTCTTCAGCAAGGACCAGTTCCCAGAGGTGTATGTGCCCACAGTGTTTGAG
AACTATGTGGCAGATATCGAGGTGGATGGAAAGCAGGTAGAGTTGGCTTTGTGGGACACA
GCTGGGCAGGAAGATTATGATCGCCTGAGGCCCCTCTCCTACCCAGATACCGATGTTATA
CTGATGTGTTTTTCCATCGACAGCCCTGATAGTTTAGAAAACATCCCAGAAAAGTGGACC
CCAGAAGTCAAGCATTTCTGTCCCAACGTGCCCATCATCCTGGTTGGGAATAAGAAGGAT
CTTCGGAATGATGAGCACACAAGGCGGGAGCTAGCCAAGATGAAGCAGGAGCCGGTGAAA
CCTGAAGAAGGCAGAGATATGGCAAACAGGATTGGCGCTTTTGGGTACATGGAGTGTTCA
GCAAAGACCAAAGATGGAGTGAGAGAGGTTTTTGAAATGGCTACGAGAGCTGCTCTGCAA
GCTAGACGTGGGAAGAAAAAATCTGGGTGCCTTGTCTTGTGA
Chromosome Location
3
Locus
3p21.3
External Identifiers
ResourceLink
UniProtKB IDP61586
UniProtKB Entry NameRHOA_HUMAN
GenBank Protein ID36030
GenBank Gene IDX05026
GenAtlas IDRHOA
HGNC IDHGNC:667
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04315Guanosine-5'-DiphosphateexperimentalunknownDetails