Beta-2-microglobulin

Details

Name
Beta-2-microglobulin
Synonyms
  • Beta-2-microglobulin form pI 5.3
Gene Name
B2M
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012637|Beta-2-microglobulin
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLL
KNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
Number of residues
119
Molecular Weight
13714.43
Theoretical pI
6.51
GO Classification
Functions
glycoprotein binding / identical protein binding
Processes
antibacterial humoral response / antigen processing and presentation of endogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / antigen processing and presentation of peptide antigen via MHC class I / cellular protein metabolic process / cellular response to iron ion / cellular response to lipopolysaccharide / cytokine-mediated signaling pathway / defense response to Gram-negative bacterium / defense response to Gram-positive bacterium / innate immune response / interferon-gamma-mediated signaling pathway / iron ion homeostasis / negative regulation of receptor binding / positive regulation of ferrous iron binding / positive regulation of ferrous iron import into cell / positive regulation of protein binding / positive regulation of receptor binding / positive regulation of receptor-mediated endocytosis / positive regulation of T cell cytokine production / positive regulation of T cell mediated cytotoxicity / positive regulation of transferrin receptor binding / protein refolding / regulation of defense response to virus by virus / regulation of immune response / regulation of membrane depolarization / response to cadmium ion / response to drug / retina homeostasis / T cell differentiation in thymus / viral process
Components
cytoplasm / early endosome lumen / early endosome membrane / endoplasmic reticulum lumen / ER to Golgi transport vesicle membrane / external side of plasma membrane / extracellular exosome / extracellular region / extracellular space / focal adhesion / Golgi apparatus / Golgi membrane / HFE-transferrin receptor complex / membrane / MHC class I protein complex / phagocytic vesicle membrane / plasma membrane
General Function
Identical protein binding
Specific Function
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0012638|Beta-2-microglobulin (B2M)
ATGTCTCGCTCCGTGGCCTTAGCTGTGCTCGCGCTACTCTCTCTTTCTGGCCTGGAGGCT
ATCCAGCGTACTCCAAAGATTCAGGTTTACTCACGTCATCCAGCAGAGAATGGAAAGTCA
AATTTCCTGAATTGCTATGTGTCTGGGTTTCATCCATCCGACATTGAAGTTGACTTACTG
AAGAATGGAGAGAGAATTGAAAAAGTGGAGCATTCAGACTTGTCTTTCAGCAAGGACTGG
TCTTTCTATCTCTTGTACTACACTGAATTCACCCCCACTGAAAAAGATGAGTATGCCTGC
CGTGTGAACCATGTGACTTTGTCACAGCCCAAGATAGTTAAGTGGGATCGAGACATGTAA
Chromosome Location
15
Locus
15q21-q22.2
External Identifiers
ResourceLink
UniProtKB IDP61769
UniProtKB Entry NameB2MG_HUMAN
GenBank Protein ID27763813
GenBank Gene IDAY187687
HGNC IDHGNC:914
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB027403-Indolebutyric AcidexperimentalunknownDetails
DB04464N-FormylmethionineexperimentalunknownDetails
DB09130Copperapproved, investigationalunknownDetails
DB11130Opiumapproved, illicitnobinderDetails