Guanine nucleotide-binding protein G(i) subunit alpha-1

Details

Name
Guanine nucleotide-binding protein G(i) subunit alpha-1
Synonyms
  • Adenylate cyclase-inhibiting G alpha protein
Gene Name
GNAI1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009412|Guanine nucleotide-binding protein G(i) subunit alpha-1
MGCTLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAG
YSEEECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVK
TTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAA
AYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVFDAVTDVIIKNNLKDCGLF
Number of residues
354
Molecular Weight
40360.685
Theoretical pI
Not Available
GO Classification
Functions
G-protein beta/gamma-subunit complex binding / G-protein coupled serotonin receptor binding / GDP binding / GTP binding / GTPase activity / metal ion binding / signal transducer activity
Processes
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway / adenylate cyclase-modulating G-protein coupled receptor signaling pathway / blood coagulation / cell cycle / cell division / G-protein coupled receptor signaling pathway / negative regulation of synaptic transmission / platelet activation / response to peptide hormone / synaptic transmission
Components
centrosome / cytoplasm / extracellular exosome / heterotrimeric G-protein complex / lysosomal membrane / membrane raft / midbody / nucleus / plasma membrane
General Function
Signal transducer activity
Specific Function
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0017452|Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1)
ATGAAAATTATCCATGAAGCTGGTTATTCAGAAGAGGAGTGTAAACAATACAAAGCAGTG
GTCTACAGTAACACCATCCAGTCAATTATTGCTATCATTAGGGCTATGGGGAGGTTGAAG
ATAGACTTTGGTGACTCAGCCCGGGCGGATGATGCACGCCAACTCTTTGTGCTAGCTGGA
GCTGCTGAAGAAGGCTTTATGACTGCAGAACTTGCTGGAGTTATAAAGAGATTGTGGAAA
GATAGTGGTGTACAAGCCTGTTTCAACAGATCCCGAGAGTACCAGCTTAATGATTCTGCA
GCATACTATTTGAATGACTTGGACAGAATAGCTCAACCAAATTACATCCCGACTCAACAA
GATGTTCTCAGAACTAGAGTGAAAACTACAGGAATTGTTGAAACCCATTTTACTTTCAAA
GATCTTCATTTTAAAATGTTTGATGTGGGAGGTCAGAGATCTGAGCGGAAGAAGTGGATT
CATTGCTTCGAAGGAGTGACGGCGATCATCTTCTGTGTAGCACTGAGTGACTACGACCTG
GTTCTAGCTGAAGATGAAGAAATGAACCGAATGCATGAAAGCATGAAATTGTTTGACAGC
ATATGTAACAACAAGTGGTTTACAGATACATCCATTATACTTTTTCTAAACAAGAAGGAT
CTCTTTGAAGAAAAAATCAAAAAGAGCCCTCTCACTATATGCTATCCAGAATATGCAGGA
TCAAACACATATGAAGAGGCAGCTGCATATATTCAATGTCAGTTTGAAGACCTCAATAAA
AGAAAGGACACAAAGGAAATATACACCCACTTCACATGTGCCACAGATACTAAGAATGTG
CAGTTTGTTTTTGATGCTGTAACAGATGTCATCATAAAAAATAATCTAAAAGATTGTGGT
CTCTTTTAA
Chromosome Location
7
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP63096
UniProtKB Entry NameGNAI1_HUMAN
HGNC IDHGNC:4384
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04315Guanosine-5'-DiphosphateexperimentalunknownDetails
DB04444Tetrafluoroaluminate IonexperimentalunknownDetails