5-formyltetrahydrofolate cyclo-ligase
Details
- Name
- 5-formyltetrahydrofolate cyclo-ligase
- Synonyms
- 5,10-methenyl-tetrahydrofolate synthetase
- 6.3.3.2
- Methenyl-THF synthetase
- MTHFS
- Gene Name
- Not Available
- Organism
- Mycoplasma pneumoniae (strain ATCC 29342 / M129)
- Amino acid sequence
>lcl|BSEQ0011366|5-formyltetrahydrofolate cyclo-ligase MDKNALRKQILQKRMALSTIEKSHLDQKINQKLVAFLTPKPCIKTIALYEPIKNEVTFVD FFFEFLKINQIRAVYPKVISDTEIIFIDQETNTFEPNQIDCFLIPLVGFNKDNYRLGFGK GYYDRYLMQLTRQQPKIGIAYSFQKGDFLADPWDVQLDLIINDE
- Number of residues
- 164
- Molecular Weight
- 19265.185
- Theoretical pI
- 7.25
- GO Classification
- Functions5-formyltetrahydrofolate cyclo-ligase activity / ATP binding / metal ion bindingComponentscytoplasm
- General Function
- Metal ion binding
- Specific Function
- Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate.
- Pfam Domain Function
- 5-FTHF_cyc-lig (PF01812)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011367|5-formyltetrahydrofolate cyclo-ligase ATGGACAAAAATGCCTTAAGAAAACAAATTCTGCAAAAAAGAATGGCATTAAGTACCATT GAAAAAAGTCACTTAGATCAAAAGATTAATCAAAAATTAGTTGCTTTTTTAACTCCTAAG CCATGCATTAAAACAATTGCACTTTATGAACCCATTAAAAATGAGGTTACTTTTGTTGAC TTCTTCTTTGAGTTTTTAAAGATTAACCAAATAAGAGCTGTTTACCCCAAGGTAATAAGT GATACCGAAATTATCTTTATTGATCAGGAGACAAATACATTCGAACCTAATCAAATAGAC TGCTTCCTAATACCATTGGTAGGCTTTAATAAAGACAATTACCGTCTAGGCTTTGGCAAG GGCTATTATGACCGTTATTTAATGCAATTAACTAGACAACAACCTAAAATAGGAATAGCG TACAGTTTCCAAAAAGGTGATTTTTTAGCCGATCCTTGGGATGTACAACTAGACTTAATT ATTAATGATGAATAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P75430 UniProtKB Entry Name MTHFS_MYCPN GenBank Protein ID 1674179 GenBank Gene ID U00089 - General References
- Himmelreich R, Hilbert H, Plagens H, Pirkl E, Li BC, Herrmann R: Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae. Nucleic Acids Res. 1996 Nov 15;24(22):4420-49. [Article]
- Chen S, Shin DH, Pufan R, Kim R, Kim SH: Crystal structure of methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087) at 2.2 A resolution. Proteins. 2004 Sep 1;56(4):839-43. [Article]
- Chen S, Yakunin AF, Proudfoot M, Kim R, Kim SH: Structural and functional characterization of a 5,10-methenyltetrahydrofolate synthetase from Mycoplasma pneumoniae (GI: 13508087). Proteins. 2005 Nov 1;61(2):433-43. [Article]