3',5'-cyclic-AMP phosphodiesterase 4B
Details
- Name
- 3',5'-cyclic-AMP phosphodiesterase 4B
- Synonyms
- 3.1.4.53
- cAMP-specific phosphodiesterase 4B
- DPDE4
- PDE32
- Gene Name
- PDE4B
- UniProtKB Entry
- Q07343Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0000972|3',5'-cyclic-AMP phosphodiesterase 4B MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG ETDIDIATEDKSPVDT
- Number of residues
- 736
- Molecular Weight
- 83342.695
- Theoretical pI
- 4.89
- GO Classification
- Functions3',5'-cyclic-GMP phosphodiesterase activity / calcium channel regulator activity / gamma-tubulin binding / transmembrane transporter bindingProcessescAMP-mediated signaling / cellular response to xenobiotic stimulus / negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway / positive regulation of type II interferon production / regulation of calcium ion transmembrane transport via high voltage-gated calcium channelComponentsnucleus / perinuclear region of cytoplasm / voltage-gated calcium channel complex
- General Function
- Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents
- Specific Function
- 3',5'-cyclic-AMP phosphodiesterase activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016107|cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B) ATGAAGGAGCACGGGGGCACCTTCAGTAGCACCGGAATCAGCGGTGGTAGCGGTGACTCT GCTATGGACAGCCTGCAGCCGCTCCAGCCTAACTACATGCCTGTGTGTTTGTTTGCAGAA GAATCTTATCAAAAATTAGCAATGGAAACGCTGGAGGAATTAGACTGGTGTTTAGACCAG CTAGAGACCATACAGACCTACCGGTCTGTCAGTGAGATGGCTTCTAACAAGTTCAAAAGA ATGCTGAACCGGGAGCTGACACACCTCTCAGAGATGAGCCGATCAGGGAACCAGGTGTCT GAATACATTTCAAATACTTTCTTAGACAAGCAGAATGATGTGGAGATCCCATCTCCTACC CAGAAAGACAGGGAGAAAAAGAAAAAGCAGCAGCTCATGACCCAGATAAGTGGAGTGAAG AAATTAATGCATAGTTCAAGCCTAAACAATACAAGCATCTCACGCTTTGGAGTCAACACT GAAAATGAAGATCACCTGGCCAAGGAGCTGGAAGACCTGAACAAATGGGGTCTTAACATC TTTAATGTGGCTGGATATTCTCACAATAGACCCCTAACATGCATCATGTATGCTATATTC CAGGAAAGAGACCTCCTAAAGACATTCAGAATCTCATCTGACACATTTATAACCTACATG ATGACTTTAGAAGACCATTACCATTCTGACGTGGCATATCACAACAGCCTGCACGCTGCT GATGTAGCCCAGTCGACCCATGTTCTCCTTTCTACACCAGCATTAGACGCTGTCTTCACA GATTTGGAGATCCTGGCTGCCATTTTTGCAGCTGCCATCCATGACGTTGATCATCCTGGA GTCTCCAATCAGTTTCTCATCAACACAAATTCAGAACTTGCTTTGATGTATAATGATGAA TCTGTGTTGGAAAATCATCACCTTGCTGTGGGTTTCAAACTGCTGCAAGAAGAACACTGT GACATCTTCATGAATCTCACCAAGAAGCAGCGTCAGACACTCAGGAAGATGGTTATTGAC ATGGTGTTAGCAACTGATATGTCTAAACATATGAGCCTGCTGGCAGACCTGAAGACAATG GTAGAAACGAAGAAAGTTACAAGTTCAGGCGTTCTTCTCCTAGACAACTATACCGATCGC ATTCAGGTCCTTCGCAACATGGTACACTGTGCAGACCTGAGCAACCCCACCAAGTCCTTG GAATTGTATCGGCAATGGACAGACCGCATCATGGAGGAATTTTTCCAGCAGGGAGACAAA GAGCGGGAGAGGGGAATGGAAATTAGCCCAATGTGTGATAAACACACAGCTTCTGTGGAA AAATCCCAGGTTGGTTTCATCGACTACATTGTCCATCCATTGTGGGAGACATGGGCAGAT TTGGTACAGCCTGATGCTCAGGACATTCTCGATACCTTAGAAGATAACAGGAACTGGTAT CAGAGCATGATACCTCAAAGTCCCTCACCACCACTGGACGAGCAGAACAGGGACTGCCAG GGTCTGATGGAGAAGTTTCAGTTTGAACTGACTCTCGATGAGGAAGATTCTGAAGGACCT GAGAAGGAGGGAGAGGGACACAGCTATTTCAGCAGCACAAAGACGCTTTGTGTGATTGAT CCAGAAAACAGAGATTCCCTGGGAGAGACTGACATAGACATTGCAACAGAAGACAAGTCC CCCGTGGATACATAA
- Chromosome Location
- 1
- Locus
- 1p31.3
- External Identifiers
Resource Link UniProtKB ID Q07343 UniProtKB Entry Name PDE4B_HUMAN GenBank Protein ID 347122 GenBank Gene ID L20966 GeneCard ID PDE4B GenAtlas ID PDE4B HGNC ID HGNC:8781 PDB ID(s) 1F0J, 1RO6, 1RO9, 1ROR, 1TB5, 1XLX, 1XLZ, 1XM4, 1XM6, 1XMU, 1XMY, 1XN0, 1XOS, 1XOT, 1Y2H, 1Y2J, 2CHM, 2QYL, 3D3P, 3FRG, 3G45, 3GWT, 3HC8, 3HDZ, 3HMV, 3KKT, 3LY2, 3O0J, 3O56, 3O57, 3W5E, 3WD9, 4KP6, 4MYQ, 4NW7, 4WZI, 4X0F, 5K6J, 5LAQ, 5OHJ, 6BOJ, 8OEG KEGG ID hsa:5142 IUPHAR/Guide To Pharmacology ID 1301 NCBI Gene ID 5142 - General References
- Obernolte R, Bhakta S, Alvarez R, Bach C, Zuppan P, Mulkins M, Jarnagin K, Shelton ER: The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family. Gene. 1993 Jul 30;129(2):239-47. [Article]
- Bolger G, Michaeli T, Martins T, St John T, Steiner B, Rodgers L, Riggs M, Wigler M, Ferguson K: A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Mol Cell Biol. 1993 Oct;13(10):6558-71. [Article]
- Huston E, Lumb S, Russell A, Catterall C, Ross AH, Steele MR, Bolger GB, Perry MJ, Owens RJ, Houslay MD: Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. Biochem J. 1997 Dec 1;328 ( Pt 2):549-58. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type 3',5'-cyclic-AMP phosphodiesterase 4B (Humans) protein primaryCyclic nucleotide phosphodiesterase (Humans) protein cAMP-specific 3',5'-cyclic phosphodiesterase 4 (PDE4) (Humans) protein Phosphodiesterase 4 (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Dyphylline approved yes target inhibitor Details Enprofylline approved, experimental yes target inhibitor Details Papaverine approved, investigational yes target inhibitor Details Caffeine approved unknown target inhibitor Details Theophylline approved yes target inhibitor Details Daxalipram experimental yes target inhibitor Details Adenosine phosphate approved, investigational, nutraceutical, withdrawn unknown target product of Details Rolipram investigational yes target inhibitor Details 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester experimental unknown target Details Filaminast experimental yes target inhibitor Details 8-Bromo-Adenosine-5'-Monophosphate experimental yes target inhibitor Details (S)-Rolipram experimental yes target inhibitor Details 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester experimental unknown target Details Cilomilast investigational yes target inhibitor Details (R)-Rolipram experimental yes target inhibitor Details S,S-(2-Hydroxyethyl)Thiocysteine experimental yes target inhibitor Details Crisaborole approved, investigational yes target inhibitor Details Piclamilast experimental yes target inhibitor Details Iloprost approved, investigational unknown target inducer Details 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide experimental unknown target Details 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid experimental unknown target Details Ibudilast investigational yes target inhibitor Details Theobromine investigational unknown target inhibitor Details 3-isobutyl-1-methyl-7H-xanthine experimental yes target inhibitor Details GSK-356278 investigational yes target inhibitor Details HT-0712 investigational yes target inhibitor Details Oglemilast investigational yes target inhibitor Details MK-0873 investigational yes target inhibitor Details AN2898 investigational yes target inhibitor Details Revamilast investigational yes target inhibitor Details Tofimilast investigational yes target inhibitor Details CDC-801 investigational yes target inhibitor Details Caffeine approved unknown target inhibitor Details Trapidil experimental yes target inhibitor Details Amrinone approved yes target inhibitor Details Rolipram investigational yes target inhibitor Details Roflumilast approved yes target inhibitor Details Ensifentrine approved, investigational yes target inhibitor Details