Apoptosis regulator BAX

Details

Name
Apoptosis regulator BAX
Synonyms
  • Bcl-2-like protein 4
  • Bcl2-L-4
  • BCL2L4
Gene Name
BAX
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052685|Apoptosis regulator BAX
MDGSGEQPRGGGPTSSEQIMKTGALLLQGFIQDRAGRMGGEAPELALDPVPQDASTKKLS
ECLKRIGDELDSNMELQRMIAAVDTDSPREVFFRVAADMFSDGNFNWGRVVALFYFASKL
VLKALCTKVPELIRTIMGWTLDFLRERLLGWIQDQGGWDGLLSYFGTPTWQTVTIFVAGV
LTASLTIWKKMG
Number of residues
192
Molecular Weight
21184.235
Theoretical pI
Not Available
GO Classification
Functions
BH3 domain binding / channel activity / chaperone binding / Hsp70 protein binding / identical protein binding / lipid binding / protein heterodimerization activity / protein homodimerization activity
Processes
activation of cysteine-type endopeptidase activity involved in apoptotic process / activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / apoptotic mitochondrial changes / apoptotic process / apoptotic process involved in blood vessel morphogenesis / apoptotic process involved in embryonic digit morphogenesis / apoptotic signaling pathway / B cell apoptotic process / B cell homeostasis / B cell homeostatic proliferation / B cell negative selection / B cell receptor apoptotic signaling pathway / blood vessel remodeling / cellular response to unfolded protein / cellular response to UV / cellular response to virus / cerebral cortex development / development of secondary sexual characteristics / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / ectopic germ cell programmed cell death / endoplasmic reticulum calcium ion homeostasis / establishment or maintenance of transmembrane electrochemical gradient / extrinsic apoptotic signaling pathway / extrinsic apoptotic signaling pathway in absence of ligand / extrinsic apoptotic signaling pathway via death domain receptors / fertilization / germ cell development / glycosphingolipid metabolic process / homeostasis of number of cells within a tissue / hypothalamus development / intrinsic apoptotic signaling pathway / intrinsic apoptotic signaling pathway by p53 class mediator / intrinsic apoptotic signaling pathway in response to DNA damage / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / kidney development / mitochondrial fragmentation involved in apoptotic process / mitochondrial fusion / mitochondrion morphogenesis / myeloid cell homeostasis / negative regulation of apoptotic signaling pathway / negative regulation of endoplasmic reticulum calcium ion concentration / negative regulation of fibroblast proliferation / negative regulation of mitochondrial membrane potential / negative regulation of neuron apoptotic process / negative regulation of peptidyl-serine phosphorylation / negative regulation of protein binding / neuron apoptotic process / neuron migration / odontogenesis of dentin-containing tooth / ovarian follicle development / positive regulation of apoptotic DNA fragmentation / positive regulation of apoptotic process / positive regulation of apoptotic process involved in mammary gland involution / positive regulation of B cell apoptotic process / positive regulation of developmental pigmentation / positive regulation of endoplasmic reticulum unfolded protein response / positive regulation of intrinsic apoptotic signaling pathway / positive regulation of IRE1-mediated unfolded protein response / positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / positive regulation of neuron apoptotic process / positive regulation of protein-containing complex assembly / positive regulation of release of cytochrome c from mitochondria / positive regulation of release of sequestered calcium ion into cytosol / post-embryonic camera-type eye morphogenesis / protein insertion into mitochondrial membrane involved in apoptotic signaling pathway / regulation of apoptotic process / regulation of mammary gland epithelial cell proliferation / regulation of mitochondrial membrane permeability involved in programmed necrotic cell death / regulation of mitochondrial membrane potential / regulation of nitrogen utilization / regulation of transcription initiation from RNA polymerase II promoter / release of cytochrome c from mitochondria / release of matrix enzymes from mitochondria / response to axon injury / response to gamma radiation / response to salt stress / response to toxic substance / retina development in camera-type eye / retinal cell programmed cell death / Sertoli cell proliferation / spermatid differentiation / T cell homeostatic proliferation / thymocyte apoptotic process / vagina development / viral process
Components
BAK complex / BAX complex / Bcl-2 family protein complex / cytoplasm / cytosol / endoplasmic reticulum / endoplasmic reticulum membrane / extracellular exosome / membrane / mitochondrial outer membrane / mitochondrial permeability transition pore complex / mitochondrion / nuclear envelope / nucleus / pore complex
General Function
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Specific Function
Bh3 domain binding
Pfam Domain Function
Transmembrane Regions
172-192
Cellular Location
Mitochondrion outer membrane
Gene sequence
>lcl|BSEQ0052686|Apoptosis regulator BAX (BAX)
ATGGACGGGTCCGGGGAGCAGCCCAGAGGCGGGGGGCCCACCAGCTCTGAGCAGATCATG
AAGACAGGGGCCCTTTTGCTTCAGGGTTTCATCCAGGATCGAGCAGGGCGAATGGGGGGG
GAGGCACCCGAGCTGGCCCTGGACCCGGTGCCTCAGGATGCGTCCACCAAGAAGCTGAGC
GAGTGTCTCAAGCGCATCGGGGACGAACTGGACAGTAACATGGAGCTGCAGAGGATGATT
GCCGCCGTGGACACAGACTCCCCCCGAGAGGTCTTTTTCCGAGTGGCAGCTGACATGTTT
TCTGACGGCAACTTCAACTGGGGCCGGGTTGTCGCCCTTTTCTACTTTGCCAGCAAACTG
GTGCTCAAGGCCCTGTGCACCAAGGTGCCGGAACTGATCAGAACCATCATGGGCTGGACA
TTGGACTTCCTCCGGGAGCGGCTGTTGGGCTGGATCCAAGACCAGGGTGGTTGGGACGGC
CTCCTCTCCTACTTTGGGACGCCCACGTGGCAGACCGTGACCATCTTTGTGGCGGGAGTG
CTCACCGCCTCACTCACCATCTGGAAGAAGATGGGCTGA
Chromosome Location
19
Locus
19q13.33
External Identifiers
ResourceLink
UniProtKB IDQ07812
UniProtKB Entry NameBAX_HUMAN
HGNC IDHGNC:959
General References
  1. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19. doi: 10.1016/0092-8674(93)90509-o. [Article]
  2. Apte SS, Mattei MG, Olsen BR: Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta. Genomics. 1995 Apr 10;26(3):592-4. doi: 10.1016/0888-7543(95)80180-t. [Article]
  3. Shi B, Triebe D, Kajiji S, Iwata KK, Bruskin A, Mahajna J: Identification and characterization of baxepsilon, a novel bax variant missing the BH2 and the transmembrane domains. Biochem Biophys Res Commun. 1999 Jan 27;254(3):779-85. doi: 10.1006/bbrc.1998.0130. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12756TAK-901investigationalunknownactivatorDetails