Hepatic sodium/bile acid cotransporter

Details

Name
Hepatic sodium/bile acid cotransporter
Synonyms
  • Cell growth-inhibiting gene 29 protein
  • Na(+)/bile acid cotransporter
  • Na(+)/taurocholate transport protein
  • NTCP
  • SLC10A1
  • Sodium/taurocholate cotransporting polypeptide
  • Solute carrier family 10 member 1
Gene Name
SLC10A1
UniProtKB Entry
Q14973Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0017172|Hepatic sodium/bile acid cotransporter
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKG
LAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNLSI
VMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKR
PQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVL
SALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLL
IAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA
Number of residues
349
Molecular Weight
38118.64
Theoretical pI
8.94
GO Classification
Processes
bile acid signaling pathway / cellular response to xenobiotic stimulus / regulation of bile acid secretion / response to estrogen / response to ethanol / response to nutrient levels / response to organic cyclic compound
General Function
As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It is strictly dependent on the extracellular presence of sodium (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321)
Specific Function
bile acid
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
25-45 60-80 91-111 120-140 156-176 191-211 220-240 283-303
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0017173|Sodium/bile acid cotransporter (SLC10A1)
ATGGAGGCCCACAACGCGTCTGCCCCATTCAACTTCACCCTGCCACCCAACTTTGGCAAG
CGCCCCACAGACCTGGCACTGAGCGTCATCCTGGTGTTCATGTTGTTCTTCATCATGCTC
TCGCTGGGCTGCACCATGGAGTTCAGCAAGATCAAGGCTCACTTATGGAAGCCTAAAGGG
CTGGCCATCGCCCTGGTGGCACAGTATGGCATCATGCCCCTCACGGCCTTTGTGCTGGGC
AAGGTCTTCCGGCTGAAGAACATTGAGGCACTGGCCATCTTGGTCTGTGGCTGCTCACCT
GGAGGGAACCTGTCCAATGTCTTCAGTCTGGCCATGAAGGGGGACATGAACCTCAGCATT
GTGATGACCACCTGCTCCACCTTCTGTGCCCTTGGCATGATGCCTCTCCTCCTGTACATC
TACTCCAGGGGGATCTATGATGGGGACCTGAAGGACAAGGTGCCCTATAAAGGCATCGTG
ATATCACTGGTCCTGGTTCTCATTCCTTGCACCATAGGGATCGTCCTCAAATCCAAACGG
CCACAATACATGCGCTATGTCATCAAGGGAGGGATGATCATCATTCTCTTGTGCAGTGTG
GCCGTCACAGTTCTCTCTGCCATCAATGTGGGGAAGAGCATCATGTTTGCCATGACACCA
CTCTTGATTGCCACCTCCTCCCTGATGCCTTTTATTGGCTTTCTGCTGGGTTATGTTCTC
TCTGCTCTCTTCTGCCTCAATGGACGGTGCAGACGCACTGTCAGCATGGAGACTGGATGC
CAAAATGTCCAACTCTGTTCCACCATCCTCAATGTGGCCTTTCCACCTGAAGTCATTGGA
CCACTTTTCTTCTTTCCCCTCCTCTACATGATTTTCCAGCTTGGAGAAGGGCTTCTCCTC
ATTGCCATATTTTGGTGCTATGAGAAATTCAAGACTCCCAAGGATAAAACAAAAATGATC
TACACAGCTGCCACAACTGAAGAAACAATTCCAGGAGCTCTGGGAAATGGCACCTACAAA
GGGGAGGACTGCTCCCCTTGCACAGCCTAG
Chromosome Location
14
Locus
14q24.1
External Identifiers
ResourceLink
UniProtKB IDQ14973
UniProtKB Entry NameNTCP_HUMAN
GenBank Protein ID410214
GenBank Gene IDL21893
GeneCard IDSLC10A1
HGNC IDHGNC:10905
PDB ID(s)7FCI, 7PQG, 7PQQ, 7VAD, 7VAG, 7WSI, 7ZYI, 8HRX, 8HRY, 8RQF
KEGG IDhsa:6554
IUPHAR/Guide To Pharmacology ID959
NCBI Gene ID6554
General References
  1. Hagenbuch B, Meier PJ: Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J Clin Invest. 1994 Mar;93(3):1326-31. [Article]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  3. Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, Huang Y, Qi Y, Peng B, Wang H, Fu L, Song M, Chen P, Gao W, Ren B, Sun Y, Cai T, Feng X, Sui J, Li W: Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. Elife. 2012 Nov 13;1:e00049. doi: 10.7554/eLife.00049. [Article]

Associated Data

Bio-Entities
Bio-EntityType
Hepatic sodium/bile acid cotransporter (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
EthinylestradiolapprovedunknowntransporterinhibitorDetails
Testosteroneapproved, investigationalunknowntransporterinhibitorDetails
Progesteroneapproved, vet_approvedunknowntransporterinhibitorDetails
Conjugated estrogensapprovedunknowntransporterinhibitorDetails
Cyclosporineapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Cholic AcidapprovedunknowntransportersubstrateinhibitorDetails
BumetanideapprovedunknowntransportersubstrateinhibitorDetails
Probenecidapproved, investigationalunknowntransporterinhibitorDetails
Ursodeoxycholic acidapproved, investigationalunknowntransportersubstrateinhibitorDetails
Taurocholic acidapproved, experimentalunknowntransportersubstrateDetails
Liothyronineapproved, vet_approvedunknowntransportersubstrateDetails
Indomethacinapproved, investigationalunknowntransportersubstrateDetails
Deoxycholic acidapprovedunknowntransportersubstrateDetails
Glycochenodeoxycholic AcidexperimentalunknowntransportersubstrateDetails
LiotrixapprovedunknowntransportersubstrateDetails
PitavastatinapprovedunknowntransportersubstrateDetails
SimeprevirapprovedunknowntransporterinhibitorDetails
Testosterone cypionateapprovedunknowntransporterinhibitorDetails
Testosterone enanthateapprovedunknowntransporterinhibitorDetails
Testosterone undecanoateapproved, investigationalunknowntransporterinhibitorDetails
RosuvastatinapprovedunknowntransporterDetails
Thyroid, porcineapprovedunknowntransportersubstrateDetails
Remdesivirapproved, investigationalunknowntransporterinhibitorDetails
Bulevirtideapproved, investigationalyestargetinhibitorDetails
Zavegepantapproved, investigationalunknowntransportersubstrateDetails
Rosiglitazoneapproved, investigationalunknowntransporterinhibitorDetails
Zafirlukastapproved, investigationalunknowntransporterinhibitorDetails
TiratricolinvestigationalunknowntransporterinhibitorDetails
SulfasalazineapprovedunknowntransporterinhibitorDetails
SulfobromophthaleinexperimentalunknowntransporterinhibitorDetails
Estrone sulfateapprovedunknowntransporterinhibitorDetails
Aprocitentanapproved, investigationalnotransporterinhibitorDetails
Maralixibatapproved, investigationalyestargetinhibitorDetails