Trans-sialidase
Details
- Name
- Trans-sialidase
- Synonyms
- Not Available
- Gene Name
- Not Available
- UniProtKB Entry
- Q26966TrEMBL
- Organism
- Trypanosoma cruzi
- NCBI Taxonomy ID
- 5693
- Amino acid sequence
>lcl|BSEQ0011807|Trans-sialidase MLAPGSSRVELFKRQSSKVPFEKDGKVTERVVHSFRLPALVNVDGVMVAIADARYETSND NSLIDTVAKYSVDDGETWETQIAIKNSRASSVSRVVDPTVIVKGNKLYVLVGSYNSSRSY WTSHGDARDWDILLAVGEVTKSTAGGKITASIKWGSPVSLKEFFPAEMEGMHTNQFLGGA GVAIVASNGNLVYPVQVTNKKKQVFSKIFYSEDEGKTWKFGKGRSAFGCSEPVALEWEGK LIINTRVDYRRRLVYESSDMGNSWLEAVGTLSRVWGPSPKSNQPGSQSSFTAVTIEGMRV MLFTHPLNFKGRWLRDRLNLWLTDNQRIYNVGQVSIGDENSAYSSVLYKDDKLYCLHEIN SNEVYSLVFARLVGELRIIKSVLQSWKNWDSHLSSICTPADPAASSSERGCGPAVTTVGL VGFLSHSATKTEWEDAYRCVNASTANAERVPNGLKFAGVGGGALWPVSQQGQNQRYRFAN HAFTVVASVTIHEVPSVASPLLGASLDSSGGKKLLGLSYDERHQWQPIYGSTPVTPTGSW EMGKRYHVVLTMANKIGSEYIDGEPLEGSGQTVVPDERTPDISHFYVGGYKRSDMPTISH VTVNNVLLYNRQLNAEEIRTLFLSQDLIGTEAHMDSSSDTSA
- Number of residues
- 642
- Molecular Weight
- 70592.955
- Theoretical pI
- 7.42
- GO Classification
- Functionsexo-alpha-sialidase activityProcessespathogenesis
- General Function
- Not Available
- Specific Function
- exo-alpha-sialidase activity
- Pfam Domain Function
- BNR_3 (PF13859)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0004974|1929 bp ATGCTGGCACCCGGATCGAGCCGAGTTGAGCTGTTTAAGCGGCAAAGCTCGAAGGTGCCA TTTGAAAAGGACGGCAAAGTCACCGAGCGGGTTGTCCACTCGTTCCGCCTCCCCGCCCTT GTTAATGTGGACGGGGTGATGGTTGCCATCGCGGACGCTCGCTACGAAACATCCAATGAC AACTCCCTCATTGATACGGTGGCGAAGTACAGCGTGGACGATGGGGAGACGTGGGAGACC CAAATTGCCATCAAGAACAGTCGTGCATCGTCTGTTTCTCGTGTGGTGGATCCCACAGTG ATTGTGAAGGGCAACAAGCTTTACGTCCTGGTTGGAAGCTACAACAGTTCGAGGAGCTAC TGGACGTCGCATGGTGATGCGAGAGACTGGGATATTCTGCTTGCCGTTGGTGAGGTCACG AAGTCCACTGCGGGCGGCAAGATAACTGCGAGTATCAAATGGGGGAGCCCCGTGTCACTG AAGGAATTTTTTCCGGCGGAAATGGAAGGAATGCACACAAATCAATTTCTTGGCGGTGCA GGTGTTGCCATTGTGGCGTCCAACGGGAATCTTGTGTACCCTGTGCAGGTTACGAACAAA AAGAAGCAAGTTTTTTCCAAGATCTTCTACTCGGAAGACGAGGGCAAGACGTGGAAGTTT GGGAAGGGTAGGAGCGCTTTTGGCTGCTCTGAACCTGTGGCCCTTGAGTGGGAGGGGAAG CTCATCATAAACACTCGAGTTGACTATCGCCGCCGTCTGGTGTACGAGTCCAGTGACATG GGGAATTCGTGGCTGGAGGCTGTCGGCACGCTCTCACGTGTGTGGGGCCCCTCACCAAAA TCGAACCAGCCCGGCAGTCAGAGCAGCTTCACTGCCGTGACCATCGAGGGAATGCGTGTT ATGCTCTTCACACACCCGCTGAATTTTAAGGGAAGGTGGCTGCGCGACCGACTGAACCTC TGGCTGACGGATAACCAGCGCATTTATAACGTTGGGCAAGTATCCATTGGTGATGAAAAT TCCGCCTACAGCTCCGTCCTGTACAAGGATGATAAGCTGTACTGTTTGCATGAGATCAAC AGTAACGAGGTGTACAGCCTTGTTTTTGCGCGCCTGGTTGGCGAGCTACGGATCATTAAA TCAGTGCTGCAGTCCTGGAAGAATTGGGACAGCCACCTGTCCAGCATTTGCACCCCTGCT GATCCAGCCGCTTCGTCGTCAGAGCGTGGTTGTGGTCCCGCTGTCACCACGGTTGGTCTT GTTGGCTTTTTGTCGCACAGTGCCACCAAAACCGAATGGGAGGATGCGTACCGCTGCGTG AACGCAAGCACGGCAAATGCGGAGAGGGTTCCGAACGGTTTGAAGTTTGCGGGGGTTGGC GGAGGGGCGCTTTGGCCGGTGAGCCAGCAGGGGCAGAATCAACGGTATCGCTTTGCAAAC CACGCGTTCACCGTGGTGGCGTCGGTGACGATTCACGAGGTTCCGAGCGTCGCGAGTCCT TTGCTGGGTGCGAGCCTGGACTCTTCTGGTGGCAAAAAACTCCTGGGGCTCTCGTACGAC GAGAGGCACCAGTGGCAGCCAATATACGGATCAACGCCGGTGACGCCGACCGGATCGTGG GAGATGGGTAAGAGGTACCACGTGGTTCTTACGATGGCGAATAAAATTGGCTCCGAGTAC ATTGATGGAGAACCTCTGGAGGGTTCAGGGCAGACCGTTGTGCCAGACGAGAGGACGCCT GACATCTCCCACTTCTACGTTGGCGGGTATAAAAGGAGTGATATGCCAACCATAAGCCAC GTGACGGTGAATAATGTTCTTCTTTACAACCGTCAGCTGAATGCCGAGGAGATCAGGACC TTGTTCTTGAGCCAGGACCTGATTGGCACGGAAGCACACATGGACAGCAGCAGCGACACG AGTGCCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q26966 UniProtKB Entry Name Q26966_TRYCR GenBank Gene ID L26499 PDB ID(s) 1MR5, 1MS0, 1MS1, 1MS3, 1MS4, 1MS5, 1MS8, 1MS9, 1S0I, 1S0J, 2AH2, 3OPZ, 3PJQ - General References
- Buschiazzo A, Amaya MF, Cremona ML, Frasch AC, Alzari PM: The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis. Mol Cell. 2002 Oct;10(4):757-68. [Article]
- Amaya MF, Watts AG, Damager I, Wehenkel A, Nguyen T, Buschiazzo A, Paris G, Frasch AC, Withers SG, Alzari PM: Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Structure. 2004 May;12(5):775-84. [Article]
- Oppezzo P, Obal G, Baraibar MA, Pritsch O, Alzari PM, Buschiazzo A: Crystal structure of an enzymatically inactive trans-sialidase-like lectin from Trypanosoma cruzi: the carbohydrate binding mechanism involves residual sialidase activity. Biochim Biophys Acta. 2011 Sep;1814(9):1154-61. doi: 10.1016/j.bbapap.2011.04.012. Epub 2011 Apr 30. [Article]
- Buschiazzo A, Muia R, Larrieux N, Pitcovsky T, Mucci J, Campetella O: Trypanosoma cruzi trans-sialidase in complex with a neutralizing antibody: structure/function studies towards the rational design of inhibitors. PLoS Pathog. 2012 Jan;8(1):e1002474. doi: 10.1371/journal.ppat.1002474. Epub 2012 Jan 5. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Trans-sialidase (Trypanosoma cruzi) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Methylumbelliferyl sialic acid experimental unknown target Details 3'-beta-Sialyl-beta-lactose experimental unknown target Details