Anoctamin-1
Details
- Name
- Anoctamin-1
- Synonyms
- Discovered on gastrointestinal stromal tumors protein 1
- DOG1
- Oral cancer overexpressed protein 2
- ORAOV2
- TAOS2
- TMEM16A
- Transmembrane protein 16A
- Tumor-amplified and overexpressed sequence 2
- Gene Name
- ANO1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008597|Anoctamin-1 MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRR KVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYH EDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSF FDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKL LYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATM DENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWA ATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHI PEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIY RISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEK SFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMEL CIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLE PFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRA KDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVNHTLSSFNV SDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLAFVIVFQNL VMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLETWMEKERQKDEPPC NHHNTKACPDSLGSPAPSHAYHGGVL
- Number of residues
- 986
- Molecular Weight
- 114077.215
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium activated cation channel activity / chloride channel activity / intracellular calcium activated chloride channel activity / iodide transmembrane transporter activity / voltage-gated chloride channel activityProcessescation transmembrane transport / cation transport / cellular response to heat / chloride transmembrane transport / chloride transport / detection of temperature stimulus involved in sensory perception of pain / iodide transport / ion transmembrane transport / multicellular organismal development / phospholipase C-activating G-protein coupled receptor signaling pathway / positive regulation of insulin secretion involved in cellular response to glucose stimulus / regulation of anion transmembrane transport / regulation of membrane potential / transmembrane transportComponentsapical plasma membrane / chloride channel complex / cytoplasm / external side of plasma membrane / extracellular exosome / plasma membrane
- General Function
- Voltage-gated chloride channel activity
- Specific Function
- Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
- Pfam Domain Function
- Transmembrane Regions
- 334-354 403-423 520-540 566-586 607-627 732-752 792-812 883-903
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0017524|Anoctamin-1 (ANO1) ATGAGGGTCAACGAGAAGTACTCGACGCTCCCGGCCGAGGACCGCAGCGTCCACATCATC AACATCTGCGCCATCGAGGACATCGGCTACCTGCCGTCCGAGGGCACGCTGCTGAACTCC TTATCTGTGGACCCTGATGCCGAGTGCAAGTATGGCCTGTACTTCAGGGACGGCCGGCGC AAGGTGGACTACATCCTGGTGTACCATCACAAGAGGCCCTCGGGCAACCGGACCCTGGTC AGGAGGGTGCAGCACAGCGACACCCCCTCTGGGGCTCGCAGCGTCAAGCAGGACCACCCC CTGCCGGGCAAGGGGGCGTCGCTGGATGCAGGCTCGGGGGAGCCCCCGATGGACTACCAC GAGGATGACAAGCGCTTCCGCAGGGAGGAGTACGAGGGCAACCTCCTGGAGGCGGGCCTG GAGCTGGAGCGGGACGAGGACACTAAAATCCACGGAGTCGGGTTTGTGAAAATCCATGCC CCCTGGAACGTGCTGTGCAGAGAGGCCGAGTTTCTGAAACTGAAGATGCCGACGAAGAAG ATGTACCACATTAATGAGACCCGTGGCCTCCTGAAAAAAATCAACTCTGTGCTCCAGAAA ATCACAGATCCCATCCAGCCCAAAGTGGCTGAGCACAGGCCCCAGACCATGAAGAGACTC TCCTATCCCTTCTCCCGGGAGAAGCAGCATCTATTTGACTTGTCTGATAAGGATTCCTTT TTCGACAGCAAAACCCGGAGCACGATTGTCTATGAGATCTTGAAGAGAACGACGTGTACA AAGGCCAAGTACAGCATGGGCATCACGAGCCTGCTGGCCAATGGTGTGTACGCGGCTGCA TACCCACTGCACGATGGAGACTACAACGGTGAAAACGTCGAGTTCAACGACAGAAAACTC CTGTACGAAGAGTGGGCACGCTATGGAGTTTTCTATAAGTACCAGCCCATCGACCTGGTC AGGAAGTATTTTGGGGAGAAGATCGGCCTGTACTTCGCCTGGCTGGGCGTGTACACCCAG ATGCTCATCCCTGCCTCCATCGTGGGAATCATTGTCTTCCTGTACGGATGCGCCACCATG GATGAAAACATCCCCAGCATGGAGATGTGTGACCAGAGACACAATATCACCATGTGCCCG CTTTGCGACAAGACCTGCAGCTACTGGAAGATGAGCTCAGCCTGCGCCACGGCCCGCGCC AGCCACCTCTTCGACAACCCCGCCACGGTCTTCTTCTCTGTCTTCATGGCCCTCTGGGCT GCCACCTTCATGGAGCACTGGAAGCGGAAACAGATGCGACTCAACTACCGCTGGGACCTC ACGGGCTTTGAAGAGGAAGAGGAGGCTGTCAAGGATCATCCTAGAGCTGAATACGAAGCC AGAGTCTTGGAGAAGTCTCTGAAGAAAGAGTCCAGAAACAAAGAGAAGCGCCGGCATATT CCAGAGGAGTCAACAAACAAATGGAAGCAGAGGGTTAAGACAGCCATGGCGGGGGTGAAA TTGACTGACAAAGTGAAGCTGACATGGAGAGATCGGTTCCCAGCCTACCTCACTAACTTG GTCTCCATCATCTTCATGATTGCAGTGACGTTTGCCATCGTCCTCGGCGTCATCATCTAC AGAATCTCCATGGCCGCCGCCTTGGCCATGAACTCCTCCCCCTCCGTGCGGTCCAACATC CGGGTCACAGTCACAGCCACCGCAGTCATCATCAACCTAGTGGTCATCATCCTCCTGGAC GAGGTGTATGGCTGCATAGCCCGATGGCTCACCAAGATCGAGGTCCCAAAGACGGAGAAA AGCTTTGAGGAGAGGCTGATCTTCAAGGCTTTCCTGCTGAAGTTTGTGAATTCCTACACC CCCATCTTTTACGTGGCGTTCTTCAAAGGCCGGTTTGTTGGACGCCCGGGCGACTACGTG TACATTTTCCGTTCCTTCCGAATGGAAGAGTGTGCGCCAGGGGGCTGCCTGATGGAGCTA TGCATCCAGCTCAGCATCATCATGCTGGGGAAACAGCTGATCCAGAACAACCTGTTCGAG ATCGGCATCCCGAAGATGAAGAAGCTCATCCGCTACCTGAAGCTGAAGCAGCAGAGCCCC CCTGACCACGAGGAGTGTGTGAAGAGGAAACAGCGGTACGAGGTGGATTACAACCTGGAG CCCTTCGCGGGCCTCACCCCAGAGTACATGGAAATGATCATCCAGTTTGGCTTCGTCACC CTGTTTGTCGCCTCCTTCCCCCTGGCCCCACTGTTTGCGCTGCTGAACAACATCATCGAG ATCCGCCTGGACGCCAAAAAGTTTGTCACTGAGCTCCGAAGGCCGGTAGCTGTCAGAGCC AAAGACATCGGAATCTGGTACAATATCCTCAGAGGCATTGGGAAGCTTGCTGTCATCATC AATGCCTTCGTGATCTCCTTCACGTCTGACTTCATCCCGCGCCTGGTGTACCTCTACATG TACAGTAAGAACGGGACCATGCACGGCTTCGTCAACCACACCCTCTCCTCCTTCAACGTC AGTGACTTCCAGAACGGCACGGCCCCCAATGACCCCCTGGACCTGGGCTACGAGGTGCAG ATCTGCAGGTATAAAGACTACCGAGAGCCGCCGTGGTCGGAAAACAAGTACGACATCTCC AAGGACTTCTGGGCCGTCCTGGCAGCCCGGCTGGCGTTTGTCATCGTCTTCCAGAACCTG GTCATGTTCATGAGCGACTTTGTGGACTGGGTCATCCCGGACATCCCCAAGGACATCAGC CAGCAGATCCACAAGGAGAAGGTGCTCATGGTGGAGCTGTTCATGCGGGAGGAGCAAGAC AAGCAGCAGCTGCTGGAAACCTGGATGGAGAAGGAGCGGCAGAAGGACGAGCCGCCGTGC AACCACCACAACACCAAAGCCTGCCCAGACAGCCTCGGCAGCCCAGCCCCCAGCCATGCC TACCACGGGGGCGTCCTGTAG
- Chromosome Location
- 11
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q5XXA6 UniProtKB Entry Name ANO1_HUMAN HGNC ID HGNC:21625 - General References
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