Organic anion transporter 3

Details

Name
Organic anion transporter 3
Synonyms
  • hOAT3
  • OAT3
  • Organic anion/dicarboxylate exchanger
  • Solute carrier family 22 member 8
Gene Name
SLC22A8
UniProtKB Entry
Q8TCC7Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0007005|Organic anion transporter 3
MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW
VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK
LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR
FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL
TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN
LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI
IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG
CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI
TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG
SS
Number of residues
542
Molecular Weight
59855.585
Theoretical pI
9.05
GO Classification
Functions
organic anion transmembrane transporter activity / prostaglandin transmembrane transporter activity / solute / xenobiotic transmembrane transporter activity
Processes
monoatomic ion transport / prostaglandin transport / transport across blood-brain barrier
Components
apical plasma membrane
General Function
Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (PubMed:14586168, PubMed:15644426, PubMed:15846473, PubMed:16455804, PubMed:31553721). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:14586168, PubMed:15846473, PubMed:15864504, PubMed:22108572, PubMed:23832370). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:11306713, PubMed:14586168, PubMed:15846473). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (PubMed:26377792). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule (PubMed:11907186). Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate (PubMed:22108572, PubMed:23832370). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (PubMed:28534121). May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside (PubMed:15644426). May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (PubMed:11669456, PubMed:15846473, PubMed:16455804). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (PubMed:14675047). May contribute to the release of cortisol in the adrenals (PubMed:15864504). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (By similarity). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (By similarity)
Specific Function
Organic anion transmembrane transporter activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
10-30 124-144 155-175 177-197 213-233 237-257 328-348 355-375 387-407 412-432 472-492
Cellular Location
Basolateral cell membrane
Gene sequence
>lcl|BSEQ0019450|Solute carrier family 22 member 8 (SLC22A8)
ATGACCTTCTCGGAGATCCTGGACCGTGTGGGAAGCATGGGCCATTTCCAGTTCCTGCAT
GTAGCCATACTGGGCCTCCCGATCCTCAACATGGCCAACCACAACCTGCTGCAGATCTTC
ACAGCCGCCACCCCTGTCCACCACTGTCGCCCGCCCCACAATGCCTCCACAGGGCCTTGG
GTGCTCCCCATGGGCCCAAATGGGAAGCCTGAGAGGTGCCTCCGTTTTGTACATCCGCCC
AATGCCAGCCTGCCCAATGACACCCAGAGGGCCATGGAGCCATGCCTGGATGGCTGGGTC
TACAACAGCACCAAGGACTCCATTGTGACAGAGTGGGACTTGGTGTGCAACTCCAACAAA
CTGAAGGAGATGGCCCAGTCTATCTTCATGGCAGGTATACTGATTGGAGGGCTCGTGCTT
GGAGACCTGTCTGACAGGTTTGGCCGCAGGCCCATCCTGACCTGCAGCTACCTGCTGCTG
GCAGCCAGCGGCTCCGGTGCAGCCTTCAGCCCCACCTTCCCCATCTACATGGTCTTCCGC
TTCCTGTGTGGCTTTGGCATCTCAGGCATTACCCTGAGCACCGTCATCTTGAATGTGGAA
TGGGTGCCTACCCGGATGCGGGCCATCATGTCGACAGCACTCGGGTACTGCTACACCTTT
GGCCAGTTCATTCTGCCCGGCCTGGCCTACGCCATCCCCCAGTGGCGTTGGCTGCAGTTA
ACTGTGTCCATTCCCTTCTTCGTCTTCTTCCTATCATCCTGGTGGACACCAGAGTCCATA
CGCTGGTTGGTCTTGTCTGGAAAGTCCTCGAAGGCCCTGAAGATACTCCGGCGGGTGGCT
GTCTTCAATGGCAAGAAGGAAGAGGGAGAAAGGCTCAGCTTGGAGGAGCTCAAACTCAAC
CTGCAGAAGGAGATCTCCTTGGCCAAGGCCAAGTACACCGCAAGTGACCTGTTCCGGATA
CCCATGCTGCGCCGCATGACCTTCTGTCTTTCCCTGGCCTGGTTTGCTACCGGTTTTGCC
TACTATAGTTTGGCTATGGGTGTGGAAGAATTTGGAGTCAACCTCTACATCCTCCAGATC
ATCTTTGGTGGGGTCGATGTCCCAGCCAAGTTCATCACCATCCTCTCCTTAAGCTACCTG
GGCCGGCATACCACTCAGGCCGCTGCCCTGCTCCTGGCAGGAGGGGCCATCTTGGCTCTC
ACCTTTGTGCCCTTGGACTTGCAGACCGTGAGGACAGTATTGGCTGTGTTTGGGAAGGGA
TGCCTATCCAGCTCCTTCAGCTGCCTCTTCCTCTACACAAGTGAATTATACCCCACAGTC
ATCAGGCAAACAGGTATGGGCGTAAGTAACCTGTGGACCCGCGTGGGAAGCATGGTGTCC
CCGCTGGTGAAAATCACGGGTGAGGTACAGCCCTTCATCCCCAATATCATCTACGGGATC
ACCGCCCTCCTCGGGGGCAGTGCTGCCCTCTTCCTGCCTGAGACCCTGAATCAGCCCTTG
CCAGAGACTATCGAAGACCTGGAAAACTGGTCCCTGCGGGCAAAGAAGCCAAAGCAGGAG
CCAGAGGTGGAAAAGGCCTCCCAGAGGATCCCTCTACAGCCTCACGGACCAGGCCTGGGC
TCCAGCTGA
Chromosome Location
11
Locus
11q12.3
External Identifiers
ResourceLink
UniProtKB IDQ8TCC7
UniProtKB Entry NameS22A8_HUMAN
GenBank Protein ID4378059
GenBank Gene IDAF097491
GeneCard IDSLC22A8
HGNC IDHGNC:10972
KEGG IDhsa:9376
IUPHAR/Guide To Pharmacology ID1027
NCBI Gene ID9376
General References
  1. Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, Ogawa O, Inui K: Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol. 2002 Apr;13(4):866-74. [Article]
  6. Bakhiya A, Bahn A, Burckhardt G, Wolff N: Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell Physiol Biochem. 2003;13(5):249-56. [Article]
  7. Srimaroeng C, Chatsudthipong V, Aslamkhan AG, Pritchard JB: Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). J Pharmacol Exp Ther. 2005 May;313(2):621-8. Epub 2005 Jan 11. [Article]
  8. Tahara H, Shono M, Kusuhara H, Kinoshita H, Fuse E, Takadate A, Otagiri M, Sugiyama Y: Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney. Pharm Res. 2005 Apr;22(4):647-60. Epub 2005 Apr 7. [Article]
  9. Tahara H, Kusuhara H, Maeda K, Koepsell H, Fuse E, Sugiyama Y: Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. Drug Metab Dispos. 2006 May;34(5):743-7. doi: 10.1124/dmd.105.008375. Epub 2006 Feb 2. [Article]
  10. Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, Urae A, Higuchi S, Otsubo K, Sugiyama Y: Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. Clin Pharmacol Ther. 2003 Jun;73(6):554-65. [Article]
  11. Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM: The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol. 2006 Apr;290(4):F905-12. Epub 2005 Nov 15. [Article]

Associated Data

Bio-Entities
Bio-EntityType
Organic anion transporter 3 (Humans)protein
primary
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Probenecidapproved, investigationalyestargetinhibitorDetails
Testosteroneapproved, investigationalunknowntransporterinducerDetails
Taurocholic acidapproved, experimentalunknowntransportersubstrateinhibitorDetails
Salicylic acidapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Quinidineapproved, investigationalunknowntransporterinhibitorDetails
Probenecidapproved, investigationalunknowntransporterinhibitorDetails
Benzylpenicillinapproved, vet_approvedunknowntransportersubstrateinhibitorDetails
OuabainapprovedunknowntransporterinhibitorDetails
Indomethacinapproved, investigationalunknowntransporterinhibitorDetails
IbuprofenapprovedunknowntransporterinhibitorDetails
GuanidineapprovedunknowntransporterinhibitorDetails
Glutaric AcidexperimentalunknowntransportersubstrateinhibitorDetails
Furosemideapproved, vet_approvedunknowntransporterinhibitorDetails
Diclofenacapproved, vet_approvedunknowntransporterinhibitorDetails
Cholic AcidapprovedunknowntransportersubstrateinhibitorDetails
BumetanideapprovedunknowntransporterinhibitorDetails
Cilastatinapproved, investigationalunknowntransporterinhibitorDetails
Piroxicamapproved, investigationalunknowntransporterinhibitorDetails
Aminohippuric acidapproved, investigationalunknowntransportersubstrateinhibitorDetails
Caprylic acidinvestigationalunknowntransporterinhibitorDetails
Cimetidineapproved, investigationalunknowntransportersubstrateinhibitorDetails
Aspartameinvestigational, nutraceuticalunknowntransporterinhibitorDetails
Tetracyclineapproved, vet_approved, withdrawnunknowntransportersubstrateinhibitorDetails
Oxytetracyclineapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Ganciclovirapproved, investigationalunknowntransporterinhibitorDetails
AcyclovirapprovedunknowntransportersubstrateinhibitorDetails
DinoprostoneapprovedunknowntransportersubstrateinhibitorDetails
Cefalotinapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Cefoperazoneapproved, investigationalunknowntransporterinhibitorDetails
CefazolinapprovedunknowntransporterinhibitorDetails
Cefamandoleapproved, experimentalunknowntransporterinhibitorDetails
Cefadroxilapproved, vet_approved, withdrawnunknowntransporterinhibitorDetails
CeftriaxoneapprovedunknowntransporterinhibitorDetails
CefotaximeapprovedunknowntransporterinhibitorDetails
Phenylbutazoneapproved, vet_approvedunknowntransporterinhibitorDetails
Ketoprofenapproved, vet_approvedunknowntransporterinhibitorDetails
PravastatinapprovednotransportersubstrateinhibitorDetails
FamotidineapprovednotransportersubstrateinhibitorDetails
Liothyronineapproved, vet_approvedunknowntransporterinhibitorDetails
MethotrexateapprovedunknowntransportersubstrateinhibitorDetails
Conjugated estrogensapprovedunknowntransportersubstrateinhibitorDetails
TenoxicamapprovedunknowntransporterinhibitorDetails
Enalaprilapproved, vet_approvedunknowntransporterinhibitorDetails
trans-2-hydroxycinnamic acidexperimentalunknowntransporterinhibitorDetails
Cephalexinapproved, investigational, vet_approvedunknowntransporterinhibitorDetails
Valproic acidapproved, investigationalunknowntransportersubstrateinhibitorDetails
Melatoninapproved, nutraceutical, vet_approvedunknowntransporterinhibitorDetails
Benzoic acidapproved, investigationalunknowntransporterinhibitorDetails
MercaptopurineapprovedunknowntransportersubstrateinhibitorDetails
Novobiocinapproved, investigational, vet_approved, withdrawnunknowntransporterinhibitorDetails
PantoprazoleapprovedunknowntransporterinhibitorDetails
Succinic acidapproved, nutraceuticalunknowntransportersubstrateDetails
Cyclic adenosine monophosphateexperimentalunknowntransportersubstrateDetails
Valaciclovirapproved, investigationalunknowntransportersubstrateDetails
Oxalic AcidexperimentalunknowntransportersubstrateDetails
Ranitidineapproved, withdrawnunknowntransportersubstrateDetails
Levocarnitineapproved, investigationalunknowntransportersubstrateDetails
AllopurinolapprovedunknowntransportersubstrateDetails
OseltamivirapprovedunknowntransportersubstrateDetails
LiotrixapprovedunknowntransporterinhibitorDetails
Cefacetrileexperimental, vet_approvedunknowntransportersubstrateinhibitorDetails
MethyltestosteroneapprovedunknowntransporterinducerDetails
ZidovudineapprovedunknowntransportersubstrateinhibitorDetails
Uric acidinvestigationalunknowntransporterDetails
Estradiolapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Prasterone sulfateinvestigationalunknowntransporterDetails
Dinoprost tromethamineapproved, vet_approvedunknowntransporterDetails
Degraded CephaloridineexperimentalunknowntransporterDetails
Tetraethylammoniumexperimental, investigationalunknowntransporterDetails
SaxagliptinapprovedunknowntransportersubstrateDetails
Dabrafenibapproved, investigationalnotransporterinhibitorDetails
Tenofovir disoproxilapproved, investigationalunknowntransportersubstrateDetails
CefotaximeapprovedunknowntargetDetails
CeftriaxoneapprovedunknowntargetDetails
Benzylpenicillinapproved, vet_approvedunknowntargetsubstrateinhibitorDetails
Eluxadolineapproved, investigationalunknowntransportersubstrateDetails
AvibactamapprovednotransportersubstrateDetails
TopiroxostatexperimentalunknowntransporterinhibitorDetails
Atalurenapproved, investigationalnoenzymeinhibitorDetails
Enasidenibapproved, investigationalunknowntransporterinhibitorDetails
Letermovirapproved, investigationalunknowntransporterinhibitorDetails
DolutegravirapprovednotransporterinhibitorDetails
Rucaparibapproved, investigationalnotransporterinhibitorDetails
Baricitinibapproved, investigationalunknowntransportersubstrateinhibitorDetails
Testosterone cypionateapprovedunknowntransporterinducerDetails
Testosterone enanthateapprovedunknowntransporterinducerDetails
Testosterone undecanoateapproved, investigationalunknowntransporterinducerDetails
Estradiol acetateapproved, investigational, vet_approvedunknowntransporterDetails
Estradiol benzoateapproved, investigational, vet_approvedunknowntransporterDetails
Estradiol cypionateapproved, investigational, vet_approvedunknowntransporterDetails
Estradiol dienanthateapproved, investigational, vet_approvedunknowntransporterDetails
Estradiol valerateapproved, investigational, vet_approvedunknowntransporterDetails
Apalutamideapproved, investigationalnotransporterinhibitorDetails
EstroneapprovedunknowntransportersubstrateDetails
CefaclorapprovedunknowntransportersubstrateinhibitorDetails
CefdinirapprovedunknowntransportersubstrateDetails
Cefotiamapproved, investigationalunknowntransportersubstrateinhibitorDetails
Ceftibutenapproved, investigationalunknowntransportersubstrateinhibitorDetails
Ceftizoximeapproved, withdrawnunknowntransportersubstrateinhibitorDetails
Cefaloridineexperimental, withdrawnunknowntransportersubstrateinhibitorDetails
Hydrocortisoneapproved, vet_approvedunknowntransportersubstrateDetails
Edaravoneapproved, investigationalnotransportersubstrateDetails
Fexofenadineapproved, investigationalunknowntransportersubstrateDetails
LeucovorinapprovedunknowntransportersubstrateinhibitorDetails
Quinaprilapproved, investigationalunknowntransportersubstrateDetails
RosuvastatinapprovedunknowntransportersubstrateinhibitorDetails
Sitagliptinapproved, investigationalunknowntransportersubstrateDetails
Hydrocortisone aceponateexperimental, vet_approvedunknowntransporterDetails
Hydrocortisone acetateapproved, vet_approvedunknowntransporterDetails
Hydrocortisone butyrateapproved, vet_approvedunknowntransporterDetails
Hydrocortisone cypionateapproved, investigational, vet_approvedunknowntransporterDetails
Hydrocortisone phosphateapproved, vet_approvedunknowntransporterDetails
Hydrocortisone probutateapproved, vet_approvedunknowntransporterDetails
Hydrocortisone valerateapproved, vet_approvedunknowntransporterDetails
Ivosidenibapproved, investigationalunknowntransporterinhibitorDetails
Lenvatinibapproved, investigationalunknowntransporterinhibitorDetails
PiperacillinapprovedunknowntransportersubstrateDetails
TazobactamapprovedunknowntransportersubstrateinhibitorDetails
RifampinapprovedunknowntransporterinhibitorDetails
Cabotegravirapproved, investigationalunknowntransporterinhibitorDetails
Dexibuprofenapproved, investigationalunknowntransporterDetails
PradigastatinvestigationalunknowntransporterinhibitorDetails
Pemetrexedapproved, investigationalnotransportersubstrateDetails
Lansoprazoleapproved, investigationalunknowntransporterinhibitorDetails
Doripenemapproved, investigationalnotransportersubstrateDetails
Acetylsalicylic acidapproved, vet_approvedunknowntransporterinhibitorDetails
Esomeprazoleapproved, investigationalunknowntransporterinhibitorDetails
Tenofovir alafenamideapprovednotransportersubstrateDetails
Tenofovirexperimental, investigationalnotransportersubstrateDetails
Naproxenapproved, vet_approvedunknowntransporterDetails
Relebactamapproved, investigationalunknowntransportersubstrateDetails
PretomanidapprovedunknowntransporterinhibitorDetails
Latanoprostapproved, investigationalunknowntransporterinhibitorDetails
Hydrochlorothiazideapproved, vet_approvedunknowntransportersubstrateDetails
GemfibrozilapprovedunknowntargetinhibitorDetails
DronedaroneapprovedunknowntransporterinhibitorDetails
BudesonideapprovedunknowntransportersubstrateDetails
Dexamethasoneapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Tafamidisapproved, investigationalunknowntransporterinhibitorDetails
Rimegepantapproved, investigationalunknowntransporterinhibitorDetails
Favipiravirapproved, investigationalunknowntransporterinhibitorDetails
Osilodrostatapproved, investigationalunknowntransporterinhibitorDetails
MedrysoneapprovedunknowntransportersubstrateDetails
Hydroflumethiazideapproved, investigational, withdrawnunknowntransportersubstrateinhibitorDetails
PolythiazideapprovedunknowntransportersubstrateDetails
Prednisolone phosphateapproved, vet_approvedunknowntransportersubstrateDetails
EmpagliflozinapprovedunknowntransportersubstrateDetails
Artesunateapproved, investigationalunknowntransporterinhibitorDetails
Betamethasone phosphateapproved, vet_approvedunknowntransportersubstrateDetails
Dexamethasone acetateapproved, investigational, vet_approvedunknowntransportersubstrateDetails
Cortisone acetateapproved, investigationalunknowntransportersubstrateDetails
Linezolidapproved, investigationalnotransporterinhibitorDetails
Cloxacillinapproved, investigational, vet_approvednotransportersubstrateinhibitorDetails
Brincidofovirapproved, investigationalnotransporterinhibitorDetails
Fexinidazoleapproved, investigationalunknowntransporterinhibitorDetails
Abrocitinibapproved, investigationalunknowntransportersubstrateDetails
Roxadustatapproved, investigationalunknowntransportersubstrateDetails
LinzagolixapprovednotransportersubstrateinhibitorDetails
Olutasidenibapproved, investigationalnotransporterinhibitorDetails
Daprodustatapproved, investigationalnotransportersubstrateDetails
OlsalazineapprovedunknowntransporterupregulatorDetails
Sparsentanapproved, investigationalunknowntransporterinhibitorDetails
Tezacaftorapproved, investigationalnotransporterinhibitorDetails
Vadadustatapproved, investigationalunknowntransportersubstrateinhibitorDetails
Encorafenibapproved, investigationalnotransporterinhibitorDetails
Capivasertibapproved, investigationalnotransporterinhibitorDetails
Avatrombopagapproved, investigationalnotransporterinhibitorDetails
Resmetiromapproved, investigationalunknowntransporterinhibitorDetails
Cefiximeapproved, investigationalunknowntransportersubstrateDetails
DeuruxolitinibinvestigationalunknowntransporterinhibitorDetails
Seladelparapproved, investigationalunknowntransportersubstrateDetails
Iron (III) oxide adipateinvestigationalyestargetinhibitorDetails
Glutaric AcidexperimentalyestargetinhibitorDetails
Aminohippuric acidapproved, investigationalyestargetinhibitorDetails
FluoresceinapprovedyestargetinhibitorDetails