Solute carrier family 22 member 8
Details
- Name
- Solute carrier family 22 member 8
- Synonyms
- hOAT3
- OAT3
- Organic anion transporter 3
- Gene Name
- SLC22A8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007005|Solute carrier family 22 member 8 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCRPPHNASTGPW VLPMGPNGKPERCLRFVHPPNASLPNDTQRAMEPCLDGWVYNSTKDSIVTEWDLVCNSNK LKEMAQSIFMAGILIGGLVLGDLSDRFGRRPILTCSYLLLAASGSGAAFSPTFPIYMVFR FLCGFGISGITLSTVILNVEWVPTRMRAIMSTALGYCYTFGQFILPGLAYAIPQWRWLQL TVSIPFFVFFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNGKKEEGERLSLEELKLN LQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQI IFGGVDVPAKFITILSLSYLGRHTTQAAALLLAGGAILALTFVPLDLQTVRTVLAVFGKG CLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGI TALLGGSAALFLPETLNQPLPETIEDLENWSLRAKKPKQEPEVEKASQRIPLQPHGPGLG SS
- Number of residues
- 542
- Molecular Weight
- 59855.585
- Theoretical pI
- 9.05
- GO Classification
- Functionsinorganic anion exchanger activity / sodium-independent organic anion transmembrane transporter activityProcessesanion transmembrane transport / response to toxic substance / sodium-independent organic anion transport / transmembrane transportComponentsbasolateral plasma membrane / extracellular exosome / integral component of plasma membrane / plasma membrane
- General Function
- Sodium-independent organic anion transmembrane transporter activity
- Specific Function
- Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).
- Pfam Domain Function
- Sugar_tr (PF00083)
- Transmembrane Regions
- 10-30 124-144 155-175 177-197 213-233 237-257 328-348 355-375 387-407 412-432 472-492
- Cellular Location
- Basolateral cell membrane
- Gene sequence
>lcl|BSEQ0019450|Solute carrier family 22 member 8 (SLC22A8) ATGACCTTCTCGGAGATCCTGGACCGTGTGGGAAGCATGGGCCATTTCCAGTTCCTGCAT GTAGCCATACTGGGCCTCCCGATCCTCAACATGGCCAACCACAACCTGCTGCAGATCTTC ACAGCCGCCACCCCTGTCCACCACTGTCGCCCGCCCCACAATGCCTCCACAGGGCCTTGG GTGCTCCCCATGGGCCCAAATGGGAAGCCTGAGAGGTGCCTCCGTTTTGTACATCCGCCC AATGCCAGCCTGCCCAATGACACCCAGAGGGCCATGGAGCCATGCCTGGATGGCTGGGTC TACAACAGCACCAAGGACTCCATTGTGACAGAGTGGGACTTGGTGTGCAACTCCAACAAA CTGAAGGAGATGGCCCAGTCTATCTTCATGGCAGGTATACTGATTGGAGGGCTCGTGCTT GGAGACCTGTCTGACAGGTTTGGCCGCAGGCCCATCCTGACCTGCAGCTACCTGCTGCTG GCAGCCAGCGGCTCCGGTGCAGCCTTCAGCCCCACCTTCCCCATCTACATGGTCTTCCGC TTCCTGTGTGGCTTTGGCATCTCAGGCATTACCCTGAGCACCGTCATCTTGAATGTGGAA TGGGTGCCTACCCGGATGCGGGCCATCATGTCGACAGCACTCGGGTACTGCTACACCTTT GGCCAGTTCATTCTGCCCGGCCTGGCCTACGCCATCCCCCAGTGGCGTTGGCTGCAGTTA ACTGTGTCCATTCCCTTCTTCGTCTTCTTCCTATCATCCTGGTGGACACCAGAGTCCATA CGCTGGTTGGTCTTGTCTGGAAAGTCCTCGAAGGCCCTGAAGATACTCCGGCGGGTGGCT GTCTTCAATGGCAAGAAGGAAGAGGGAGAAAGGCTCAGCTTGGAGGAGCTCAAACTCAAC CTGCAGAAGGAGATCTCCTTGGCCAAGGCCAAGTACACCGCAAGTGACCTGTTCCGGATA CCCATGCTGCGCCGCATGACCTTCTGTCTTTCCCTGGCCTGGTTTGCTACCGGTTTTGCC TACTATAGTTTGGCTATGGGTGTGGAAGAATTTGGAGTCAACCTCTACATCCTCCAGATC ATCTTTGGTGGGGTCGATGTCCCAGCCAAGTTCATCACCATCCTCTCCTTAAGCTACCTG GGCCGGCATACCACTCAGGCCGCTGCCCTGCTCCTGGCAGGAGGGGCCATCTTGGCTCTC ACCTTTGTGCCCTTGGACTTGCAGACCGTGAGGACAGTATTGGCTGTGTTTGGGAAGGGA TGCCTATCCAGCTCCTTCAGCTGCCTCTTCCTCTACACAAGTGAATTATACCCCACAGTC ATCAGGCAAACAGGTATGGGCGTAAGTAACCTGTGGACCCGCGTGGGAAGCATGGTGTCC CCGCTGGTGAAAATCACGGGTGAGGTACAGCCCTTCATCCCCAATATCATCTACGGGATC ACCGCCCTCCTCGGGGGCAGTGCTGCCCTCTTCCTGCCTGAGACCCTGAATCAGCCCTTG CCAGAGACTATCGAAGACCTGGAAAACTGGTCCCTGCGGGCAAAGAAGCCAAAGCAGGAG CCAGAGGTGGAAAAGGCCTCCCAGAGGATCCCTCTACAGCCTCACGGACCAGGCCTGGGC TCCAGCTGA
- Chromosome Location
- 11
- Locus
- 11q11
- External Identifiers
Resource Link UniProtKB ID Q8TCC7 UniProtKB Entry Name S22A8_HUMAN GenBank Protein ID 4378059 GenBank Gene ID AF097491 HGNC ID HGNC:10972 - General References
- Race JE, Grassl SM, Williams WJ, Holtzman EJ: Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3). Biochem Biophys Res Commun. 1999 Feb 16;255(2):508-14. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Motohashi H, Sakurai Y, Saito H, Masuda S, Urakami Y, Goto M, Fukatsu A, Ogawa O, Inui K: Gene expression levels and immunolocalization of organic ion transporters in the human kidney. J Am Soc Nephrol. 2002 Apr;13(4):866-74. [Article]
- Bakhiya A, Bahn A, Burckhardt G, Wolff N: Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux. Cell Physiol Biochem. 2003;13(5):249-56. [Article]
- Srimaroeng C, Chatsudthipong V, Aslamkhan AG, Pritchard JB: Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8). J Pharmacol Exp Ther. 2005 May;313(2):621-8. Epub 2005 Jan 11. [Article]
- Tahara H, Shono M, Kusuhara H, Kinoshita H, Fuse E, Takadate A, Otagiri M, Sugiyama Y: Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney. Pharm Res. 2005 Apr;22(4):647-60. Epub 2005 Apr 7. [Article]
- Tahara H, Kusuhara H, Maeda K, Koepsell H, Fuse E, Sugiyama Y: Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid. Drug Metab Dispos. 2006 May;34(5):743-7. doi: 10.1124/dmd.105.008375. Epub 2006 Feb 2. [Article]
- Nishizato Y, Ieiri I, Suzuki H, Kimura M, Kawabata K, Hirota T, Takane H, Irie S, Kusuhara H, Urasaki Y, Urae A, Higuchi S, Otsubo K, Sugiyama Y: Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics. Clin Pharmacol Ther. 2003 Jun;73(6):554-65. [Article]
- Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, Burchard EG, Giacomini KM: The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. Am J Physiol Renal Physiol. 2006 Apr;290(4):F905-12. Epub 2005 Nov 15. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01032 Probenecid approved, investigational yes inhibitor Details DB00624 Testosterone approved, investigational unknown inducer Details DB04348 Taurocholic acid approved, experimental unknown substrateinhibitor Details DB00936 Salicylic acid approved, investigational, vet_approved unknown inhibitor Details DB00908 Quinidine approved, investigational unknown inhibitor Details DB01032 Probenecid approved, investigational unknown inhibitor Details DB01053 Benzylpenicillin approved, vet_approved unknown substrateinhibitor Details DB01092 Ouabain approved unknown inhibitor Details DB00328 Indomethacin approved, investigational unknown inhibitor Details DB01050 Ibuprofen approved unknown inhibitor Details DB00536 Guanidine approved unknown inhibitor Details DB03553 Glutaric Acid experimental unknown substrateinhibitor Details DB00695 Furosemide approved, vet_approved unknown inhibitor Details DB00586 Diclofenac approved, vet_approved unknown inhibitor Details DB02659 Cholic Acid approved unknown substrateinhibitor Details DB00887 Bumetanide approved unknown inhibitor Details DB01597 Cilastatin approved, investigational unknown inhibitor Details DB00554 Piroxicam approved, investigational unknown inhibitor Details DB00345 Aminohippuric acid approved, investigational unknown substrateinhibitor Details DB04519 Caprylic acid investigational unknown inhibitor Details DB00501 Cimetidine approved, investigational unknown substrateinhibitor Details DB00168 Aspartame investigational, nutraceutical unknown inhibitor Details DB00759 Tetracycline approved, vet_approved, withdrawn unknown substrateinhibitor Details DB00595 Oxytetracycline approved, investigational, vet_approved unknown substrate Details DB01004 Ganciclovir approved, investigational unknown inhibitor Details DB00787 Acyclovir approved unknown substrateinhibitor Details DB00917 Dinoprostone approved unknown substrateinhibitor Details DB00456 Cefalotin approved, investigational, vet_approved unknown inhibitor Details DB01329 Cefoperazone approved, investigational unknown inhibitor Details DB01327 Cefazolin approved unknown inhibitor Details DB01326 Cefamandole approved, experimental unknown inhibitor Details DB01140 Cefadroxil approved, vet_approved, withdrawn unknown inhibitor Details DB01212 Ceftriaxone approved unknown inhibitor Details DB00493 Cefotaxime approved unknown inhibitor Details DB00812 Phenylbutazone approved, vet_approved unknown inhibitor Details DB01009 Ketoprofen approved, vet_approved unknown inhibitor Details DB00175 Pravastatin approved no substrateinhibitor Details DB00927 Famotidine approved no substrateinhibitor Details DB00279 Liothyronine approved, vet_approved unknown inhibitor Details DB00563 Methotrexate approved unknown substrateinhibitor Details DB00286 Conjugated estrogens approved unknown substrateinhibitor Details DB00469 Tenoxicam approved unknown inhibitor Details DB00584 Enalapril approved, vet_approved unknown inhibitor Details DB01650 trans-2-hydroxycinnamic acid experimental unknown inhibitor Details DB00567 Cephalexin approved, investigational, vet_approved unknown inhibitor Details DB00313 Valproic acid approved, investigational unknown substrateinhibitor Details DB01065 Melatonin approved, nutraceutical, vet_approved unknown inhibitor Details DB03793 Benzoic acid approved, investigational unknown inhibitor Details DB01033 Mercaptopurine approved unknown substrateinhibitor Details DB01051 Novobiocin approved, investigational, vet_approved, withdrawn unknown inhibitor Details DB00213 Pantoprazole approved unknown inhibitor Details DB00139 Succinic acid approved, nutraceutical unknown substrate Details DB02527 Cyclic adenosine monophosphate experimental unknown substrate Details DB00577 Valaciclovir approved, investigational unknown substrate Details DB03902 Oxalic Acid experimental unknown substrate Details DB00863 Ranitidine approved, withdrawn unknown substrate Details DB00583 Levocarnitine approved, investigational unknown substrate Details DB00437 Allopurinol approved unknown substrate Details DB00198 Oseltamivir approved unknown substrate Details DB01583 Liotrix approved unknown inhibitor Details DB01414 Cefacetrile experimental, vet_approved unknown substrateinhibitor Details DB06710 Methyltestosterone approved unknown inducer Details DB00495 Zidovudine approved unknown substrateinhibitor Details DB08844 Uric acid investigational unknown Details DB00783 Estradiol approved, investigational, vet_approved unknown substrate Details DB05804 Prasterone sulfate investigational unknown Details DB01160 Dinoprost tromethamine approved, vet_approved unknown Details DB04133 Degraded Cephaloridine experimental unknown Details DB08837 Tetraethylammonium experimental, investigational unknown Details DB06335 Saxagliptin approved unknown substrate Details DB08912 Dabrafenib approved, investigational no inhibitor Details DB00300 Tenofovir disoproxil approved, investigational unknown substrate Details DB00493 Cefotaxime approved unknown Details DB01212 Ceftriaxone approved unknown Details DB01053 Benzylpenicillin approved, vet_approved unknown substrateinhibitor Details DB09272 Eluxadoline approved, investigational unknown substrate Details DB09060 Avibactam approved no substrate Details DB01685 Topiroxostat experimental unknown inhibitor Details DB05016 Ataluren approved, investigational no inhibitor Details DB13874 Enasidenib approved, investigational unknown inhibitor Details DB12070 Letermovir approved, investigational unknown inhibitor Details DB08930 Dolutegravir approved no inhibitor Details DB12332 Rucaparib approved, investigational no inhibitor Details DB11817 Baricitinib approved, investigational unknown substrateinhibitor Details DB13943 Testosterone cypionate approved unknown inducer Details DB13944 Testosterone enanthate approved unknown inducer Details DB13946 Testosterone undecanoate approved, investigational unknown inducer Details DB13952 Estradiol acetate approved, investigational, vet_approved unknown Details DB13953 Estradiol benzoate approved, investigational, vet_approved unknown Details DB13954 Estradiol cypionate approved, investigational, vet_approved unknown Details DB13955 Estradiol dienanthate approved, investigational, vet_approved unknown Details DB13956 Estradiol valerate approved, investigational, vet_approved unknown Details DB11901 Apalutamide approved, investigational no inhibitor Details DB11995 Avatrombopag approved, investigational unknown inhibitor Details DB00655 Estrone approved unknown substrate Details DB00833 Cefaclor approved unknown substrateinhibitor Details DB00535 Cefdinir approved unknown substrate Details DB00229 Cefotiam approved, investigational unknown substrateinhibitor Details DB01415 Ceftibuten approved, investigational unknown substrateinhibitor Details DB01332 Ceftizoxime approved, withdrawn unknown substrateinhibitor Details DB09008 Cefaloridine experimental, withdrawn unknown substrateinhibitor Details DB00741 Hydrocortisone approved, vet_approved unknown substrate Details DB12243 Edaravone approved, investigational no substrate Details DB00950 Fexofenadine approved, investigational unknown substrate Details DB00650 Leucovorin approved unknown substrateinhibitor Details DB00881 Quinapril approved, investigational unknown substrate Details DB01098 Rosuvastatin approved unknown substrateinhibitor Details DB01261 Sitagliptin approved, investigational unknown substrate Details DB14538 Hydrocortisone aceponate experimental, vet_approved unknown Details DB14539 Hydrocortisone acetate approved, vet_approved unknown Details DB14540 Hydrocortisone butyrate approved, vet_approved unknown Details DB14541 Hydrocortisone cypionate approved, investigational, vet_approved unknown Details DB14542 Hydrocortisone phosphate approved, vet_approved unknown Details DB14543 Hydrocortisone probutate approved, vet_approved unknown Details DB14544 Hydrocortisone valerate approved, vet_approved unknown Details DB14568 Ivosidenib approved, investigational unknown inhibitor Details DB09078 Lenvatinib approved, investigational unknown inhibitor Details DB00319 Piperacillin approved unknown substrate Details DB01606 Tazobactam approved unknown substrateinhibitor Details DB01045 Rifampicin approved unknown inhibitor Details DB11751 Cabotegravir approved, investigational unknown inhibitor Details DB09213 Dexibuprofen approved, investigational unknown Details DB12866 Pradigastat investigational unknown inhibitor Details DB00642 Pemetrexed approved, investigational no substrate Details DB00448 Lansoprazole approved, investigational unknown inhibitor Details DB06211 Doripenem approved, investigational no substrate Details DB00945 Acetylsalicylic acid approved, vet_approved unknown inhibitor Details DB00736 Esomeprazole approved, investigational unknown inhibitor Details DB09299 Tenofovir alafenamide approved no substrate Details DB14126 Tenofovir experimental, investigational no substrate Details DB00788 Naproxen approved, vet_approved unknown Details DB12377 Relebactam approved, investigational unknown substrate Details DB05154 Pretomanid approved unknown inhibitor Details DB00654 Latanoprost approved, investigational unknown inhibitor Details DB00999 Hydrochlorothiazide approved, vet_approved unknown substrate Details DB01241 Gemfibrozil approved unknown inhibitor Details DB04855 Dronedarone approved unknown inhibitor Details DB01222 Budesonide approved unknown substrate Details DB01234 Dexamethasone approved, investigational, vet_approved unknown substrate Details DB11644 Tafamidis approved, investigational unknown inhibitor Details DB12457 Rimegepant approved, investigational unknown inhibitor Details DB12466 Favipiravir approved, investigational unknown inhibitor Details DB11837 Osilodrostat approved, investigational unknown inhibitor Details DB00253 Medrysone approved unknown substrate Details DB00774 Hydroflumethiazide approved, investigational, withdrawn unknown substrateinhibitor Details DB01324 Polythiazide approved unknown substrate Details DB14631 Prednisolone phosphate approved, vet_approved unknown substrate Details DB09038 Empagliflozin approved unknown substrate Details DB09274 Artesunate approved, investigational unknown inhibitor Details DB14669 Betamethasone phosphate approved, vet_approved unknown substrate Details DB14649 Dexamethasone acetate approved, investigational, vet_approved unknown substrate Details DB01380 Cortisone acetate approved, investigational unknown substrate Details DB00601 Linezolid approved, investigational no inhibitor Details DB01147 Cloxacillin approved, investigational, vet_approved no substrateinhibitor Details DB12151 Brincidofovir approved, investigational no inhibitor Details DB12265 Fexinidazole approved, investigational unknown inhibitor Details DB14973 Abrocitinib approved, investigational unknown substrate Details DB04847 Roxadustat approved, investigational unknown substrate Details DB17083 Linzagolix approved no substrateinhibitor Details DB16267 Olutasidenib approved, investigational no inhibitor Details DB11682 Daprodustat approved, investigational no substrate Details DB01250 Olsalazine approved unknown upregulator Details DB12548 Sparsentan approved, investigational unknown inhibitor Details DB11712 Tezacaftor approved, investigational no inhibitor Details DB12255 Vadadustat approved, investigational unknown substrateinhibitor Details