Gamma-aminobutyric acid receptor subunit gamma-3

Details

Name
Gamma-aminobutyric acid receptor subunit gamma-3
Synonyms
  • GABA(A) receptor subunit gamma-3
  • GABAAR subunit gamma-3
Gene Name
GABRG3
UniProtKB Entry
Q99928Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0006921|Gamma-aminobutyric acid receptor subunit gamma-3
MAPKLLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLREYDK
KLRPDIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNS
NMVGLIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPM
DEHSCPLIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTSAGDY
VVMTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLS
TIARKSLPRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDS
SRWIPERISLQAPSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCC
YEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVGYLYL
Number of residues
467
Molecular Weight
54288.16
Theoretical pI
7.58
GO Classification
Functions
GABA-gated chloride ion channel activity / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Processes
inhibitory synapse assembly / regulation of postsynaptic membrane potential / response to xenobiotic stimulus / synaptic transmission, GABAergic
Components
dendrite membrane / GABA-ergic synapse / microtubule cytoskeleton / nucleolus / postsynapse / transmembrane transporter complex
General Function
Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride across the cell membrane down their electrochemical gradient (By similarity)
Specific Function
GABA-A receptor activity
Pfam Domain Function
Signal Regions
1-17
Transmembrane Regions
257-277 284-303 312-332 447-467
Cellular Location
Postsynaptic cell membrane
Gene sequence
>lcl|BSEQ0012498|Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3)
ATGGCCCCGAAGCTGCTGCTCCTCCTCTGCCTGTTCTCGGGCTTGCACGCGCGGTCCAGA
AAGGTGGAAGAGGATGAATATGAAGATTCATCATCAAACCAAAAGTGGGTCTTGGCTCCA
AAATCCCAAGACACCGACGTGACTCTTATTCTCAACAAGTTGCTAAGAGAATATGATAAA
AAGCTGAGGCCAGATATTGGAATAAAACCGACCGTAATTGACGTTGACATTTATGTTAAC
AGCATTGGTCCTGTGTCATCAATAAACATGGAATACCAAATTGACATATTTTTTGCTCAG
ACCTGGACAGATAGTCGCCTTCGATTCAACAGCACAATGAAAATTCTTACTCTGAACAGC
AACATGGTGGGGTTAATCTGGATCCCAGACACCATCTTCCGCAATTCTAAAACCGCAGAG
GCTCACTGGATCACCACACCCAATCAGCTCCTCCGGATTTGGAATGACGGGAAAATCCTT
TACACTTTGAGGCTCACCATCAATGCTGAGTGCCAGCTGCAGCTGCACAACTTCCCCATG
GACGAACACTCCTGCCCGCTGATTTTCTCCAGCTATGGCTATCCCAAAGAAGAAATGATT
TATAGATGGAGAAAAAATTCAGTGGAGGCAGCTGACCAGAAATCATGGCGGCTTTATCAG
TTTGACTTCATGGGCCTCAGAAACACCACAGAAATCGTGACAACGTCTGCAGGTAGGAAT
TTACTGAAAGAGGCACAGCTCTCAAAAGCCAGAGAGGCCTAA
Chromosome Location
15
Locus
15q12
External Identifiers
ResourceLink
UniProtKB IDQ99928
UniProtKB Entry NameGBRG3_HUMAN
GenBank Protein ID1754749
GenBank Gene IDS82769
GeneCard IDGABRG3
HGNC IDHGNC:4088
KEGG IDhsa:2567
NCBI Gene ID2567
General References
  1. Hadingham KL, Wafford KA, Thompson SA, Palmer KJ, Whiting PJ: Expression and pharmacology of human GABAA receptors containing gamma 3 subunits. Eur J Pharmacol. 1995 Nov 30;291(3):301-9. [Article]
  2. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Associated Data

Bio-Entities
Bio-EntityType
Gamma-aminobutyric acid receptor subunit gamma-3 (Humans)protein
primary
GABA(A) Receptor (Humans)protein
GABA(A) Receptor Benzodiazepine Binding Site (Humans)protein
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Fludiazepamexperimental, illicityestargetpotentiatorDetails
EthanolapprovedunknowntargetDetails
OcinaploninvestigationalyestargetmodulatorDetails
ORG-25435investigationalyestargetmodulatorDetails
AZD-3043investigationalyestargetmodulatorDetails
EVT 201investigationalyestargetmodulatorDetails
PagocloneinvestigationalyestargetmodulatorDetails
Zuranoloneapproved, experimentalyestargetmodulatorDetails
ClomethiazoleinvestigationalyestargetmodulatorDetails
Arbaclofen PlacarbilinvestigationalyestargetagonistDetails
Remimazolamapproved, investigationalyestargetagonistDetails
BentazepamexperimentalyestargetmodulatorDetails
StiripentolapprovedyestargetmodulatorDetails
Zolpidemapprovedyestargetallosteric modulatorDetails
Flumazenilapprovedyestargetallosteric modulatorDetails
MebutamateapprovedyestargetmodulatorDetails
MetharbitalwithdrawnyestargetmodulatorDetails
EtomidateapprovedyestargetmodulatorDetails
Thiamylalapproved, vet_approvedyestargetmodulatorDetails
Clobazamapproved, illicityestargetmodulatorDetails
Talbutalapproved, illicityestargetmodulatorDetails
Brexanoloneapproved, investigationalyestargetmodulatorDetails
Desfluraneapprovedyestargetpositive allosteric modulatorDetails
Alprazolamapproved, illicit, investigationalyestargetpositive allosteric modulatorDetails
Butabarbitalapproved, illicityestargetpositive allosteric modulatorDetails
Chlordiazepoxideapproved, illicit, investigationalyestargetpositive allosteric modulatorDetails
Clobazamapproved, illicityestargetpositive allosteric modulatorDetails
Clonazepamapproved, illicityestargetpositive allosteric modulatorDetails
Clorazepic acidapproved, illicityestargetpositive allosteric modulatorDetails
Lorazepamapprovedyestargetpositive allosteric modulatorDetails
Ethchlorvynolapproved, illicit, withdrawnyestargetpositive allosteric modulatorDetails
Enfluraneapproved, investigational, vet_approvedyestargetpotentiatorDetails
Temazepamapproved, investigationalyestargetpositive allosteric modulatorDetails
Butalbitalapproved, illicityestargetpositive allosteric modulatorDetails
Etomidateapprovedyestargetpositive allosteric modulatorDetails
Talbutalapproved, illicityestargetpositive allosteric modulatorDetails
Pentobarbitalapproved, investigational, vet_approvedyestargetpositive allosteric modulatorDetails
Meprobamateapproved, illicityestargetpositive allosteric modulatorDetails
Eszopicloneapproved, investigationalyestargetpositive allosteric modulatorDetails
Metharbitalwithdrawnyestargetpositive allosteric modulatorDetails
Isofluraneapproved, vet_approvedyestargetpositive allosteric modulatorDetails
Primidoneapproved, vet_approvedyestargetpositive allosteric modulatorDetails
Halazepamapproved, illicit, withdrawnyestargetpositive allosteric modulatorDetails
Propofolapproved, investigational, vet_approvedyestargetpositive allosteric modulatorDetails
Diazepamapproved, illicit, investigational, vet_approvedyestargetpositive allosteric modulatorDetails
Oxazepamapprovedyestargetpositive allosteric modulatorDetails
Methoxyfluraneapproved, investigational, vet_approved, withdrawnyestargetpositive allosteric modulatorDetails
Methyprylonapproved, illicit, withdrawnyestargetpositive allosteric modulatorDetails
Halothaneapproved, vet_approvedyestargetpositive allosteric modulatorDetails
Flumazenilapprovedyestargetpositive allosteric modulatorDetails
Estazolamapproved, illicityestargetpositive allosteric modulatorDetails
Sevofluraneapproved, vet_approvedyestargetagonistDetails
Glutethimideapproved, illicityestargetpositive allosteric modulatorDetails
Prazepamapproved, illicityestargetpositive allosteric modulatorDetails
Quazepamapproved, illicityestargetpositive allosteric modulatorDetails
AmoxapineapprovedunknowntargetbinderDetails
Prasteroneapproved, investigational, nutraceuticalunknowntargetantagonistDetails
ThiocolchicosideexperimentalyestargetantagonistDetails
Stiripentolapprovedyestargetagonistpositive allosteric modulatorDetails
Taurineapproved, nutraceuticalyestargetagonistDetails
Lamotrigineapproved, investigationalunknowntargetantagonistinducerDetails
Apalutamideapproved, investigationalnotargetantagonistDetails
Brexanoloneapproved, investigationalyestargetpositive allosteric modulatorDetails
Memantineapproved, investigationalunknowntargetbinderDetails
Medroxyprogesterone acetateapproved, investigationalunknowntargetinhibitorDetails
Phenytoinapproved, vet_approvedunknowntargetDetails
Midazolamapproved, illicityestargetpositive allosteric modulatorDetails
Flurazepamapproved, illicit, investigationalyestargetpositive allosteric modulatorDetails
Triazolamapproved, investigationalyestargetpositive allosteric modulatorDetails
Bromazepamapproved, illicit, investigationalyestargetpositive allosteric modulatorDetails
Nitrazepamapprovedyestargetpositive allosteric modulatorDetails
Camazepamexperimental, illicityestargetpositive allosteric modulatorDetails
Delorazepamexperimental, illicityestargetpositive allosteric modulatorDetails
Flunitrazepamapproved, illicityestargetpositive allosteric modulatorDetails
Etizolamexperimentalyestargetpositive allosteric modulatorDetails
Medazepamexperimentalyestargetpositive allosteric modulatorDetails
Doxefazepamexperimentalyestargetpositive allosteric modulatorDetails
Lormetazepamapprovedyestargetpositive allosteric modulatorDetails
Nordazepamexperimentalyestargetpositive allosteric modulatorDetails
Adinazolamexperimentalyestargetpositive allosteric modulatorDetails
Ethyl loflazepateexperimental, illicityestargetpositive allosteric modulatorDetails
Cloxazolamexperimentalyestargetpositive allosteric modulatorDetails
Clotiazepamapproved, illicityestargetpositive allosteric modulatorDetails
Ketazolamapprovedyestargetpositive allosteric modulatorDetails
Cinolazepamexperimentalyestargetpositive allosteric modulatorDetails
Brotizolaminvestigational, withdrawnyestargetpositive allosteric modulatorDetails
Pinazepamexperimentalyestargetpositive allosteric modulatorDetails
Loprazolamexperimentalyestargetpositive allosteric modulatorDetails
Oxazepam acetateexperimentalyestargetpositive allosteric modulatorDetails
1,2-Benzodiazepineapproved, investigationalunknowntargetpositive allosteric modulatorDetails
Cinazepamexperimentalyestargetpositive allosteric modulatorDetails
Bentazepamexperimentalyestargetpositive allosteric modulatorDetails
Mexazolamexperimentalyestargetpositive allosteric modulatorDetails
Remimazolamapproved, investigationalyestargetpositive allosteric modulatorDetails
Ganaxoloneapproved, investigationalyestargetpositive allosteric modulatorDetails
Zuranoloneapproved, experimentalyestargetpositive allosteric modulatorDetails
Adipiploninvestigationalyestargetpartial agonistDetails
5,7,2′-trihydroxy-6,8-dimethoxyflavoneexperimentalunknowntargetligandDetails
Lamotrigineapproved, investigationalunknowntargetinhibitorDetails
Olanzapineapproved, investigationalnotargetinhibitorDetails
MexazolamexperimentalyestargetligandDetails
OxazepamapprovedyestargetligandDetails
Alprazolamapproved, illicit, investigationalyestargetligandDetails
LorazepamapprovedyestargetligandDetails
Temazepamapproved, investigationalunknowntargetligandDetails
Chlordiazepoxideapproved, illicit, investigationalyestargetligandDetails
Clorazepic acidapproved, illicityestargetligandDetails
Midazolamapproved, illicityestargetligandDetails
Flurazepamapproved, illicit, investigationalyestargetligandDetails
Diazepamapproved, illicit, investigational, vet_approvedyestargetligandDetails
Triazolamapproved, investigationalyestargetligandDetails
Clonazepamapproved, illicityestargetligandDetails
Estazolamapproved, illicityestargetligandDetails
Bromazepamapproved, illicit, investigationalyestargetligandDetails
NitrazepamapprovedyestargetligandDetails
Clobazamapproved, illicityestargetligandDetails
Camazepamexperimental, illicityestargetligandDetails
Delorazepamexperimental, illicityestargetligandDetails
Flunitrazepamapproved, illicityestargetligandDetails
Prazepamapproved, illicityestargetligandDetails
EtizolamexperimentalyestargetligandDetails
MedazepamexperimentalyestargetligandDetails
DoxefazepamexperimentalyestargetligandDetails
LormetazepamapprovedyestargetligandDetails
NordazepamexperimentalyestargetligandDetails
AdinazolamexperimentalyestargetligandDetails
Halazepamapproved, illicit, withdrawnunknowntargetligandDetails
Ethyl loflazepateexperimental, illicityestargetligandDetails
CloxazolamexperimentalyestargetligandDetails
Clotiazepamapproved, illicityestargetligandDetails
KetazolamapprovedyestargetligandDetails
CinolazepamexperimentalyestargetligandDetails
Brotizolaminvestigational, withdrawnyestargetligandDetails
PinazepamexperimentalyestargetligandDetails
LoprazolamexperimentalunknowntargetligandDetails
Quazepamapproved, illicityestargetligandDetails
Oxazepam acetateexperimentalyestargetligandDetails
1,2-Benzodiazepineapproved, investigationalunknowntargetligandDetails
CinazepamexperimentalyestargetligandDetails
BentazepamexperimentalyestargetligandDetails
Remimazolamapproved, investigationalyestargetligandDetails
Zonisamideapproved, investigationalunknowntargetbinderDetails