Interleukin-1 receptor-like 2

Details

Name

Interleukin-1 receptor-like 2

Synonyms

• 3.2.2.6
• IL-1Rrp2
• IL-36 receptor
• IL-36R
• IL1R-rp2
• IL1RRP2
• Interleukin-1 receptor-related protein 2

Gene Name

IL1RL2

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052791|Interleukin-1 receptor-like 2
MWSLLLCGLSIALPLSVTADGCKDIFMKNEILSASQPFAFNCTFPPITSGEVSVTWYKNS
SKIPVSKIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSCHRIHVNLTVFEKHWCDT
SIGGLPNLSDEYKQILHLGKDDSLTCHLHFPKSCVLGPIKWYKDCNEIKGERFTVLETRL
LVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSITERAGYGGSVPKIIYPKNHSIEVQ
LGTTLIVDCNVTDTKDNTNLRCWRVNNTLVDDYYDESKRIREGVETHVSFREHNLYTVNI
TFLEVKMEDYGLPFMCHAGVSTAYIILQLPAPDFRAYLIGGLIALVAVAVSVVYIYNIFK
IDIVLWYRSAFHSTETIVDGKLYDAYVLYPKPHKESQRHAVDALVLNILPEVLERQCGYK
LFIFGRDEFPGQAVANVIDENVKLCRRLIVIVVPESLGFGLLKNLSEEQIAVYSALIQDG
MKVILIELEKIEDYTVMPESIQYIKQKHGAIRWHGDFTEQSQCMKTKFWKTVRYHMPPRR
CRPFPPVQLLQHTPCYRTAGPELGSRRKKCTLTTG

Number of residues

575

Molecular Weight

65404.06

Theoretical pI

Not Available

GO Classification

Functions

interleukin-1 receptor activity / interleukin-1, Type I, activating receptor activity / NAD(P)+ nucleosidase activity / NAD+ nucleotidase, cyclic ADP-ribose generating

Processes

cellular defense response / inflammatory response / innate immune response / positive regulation of interleukin-6 production / positive regulation of T cell differentiation / regulation of inflammatory response / signal transduction

Components

integral component of plasma membrane / plasma membrane

General Function

Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways (By similarity). The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.

Specific Function

Interleukin-1 receptor activity

Pfam Domain Function

• TIR (PF01582)
• Ig_2 (PF13895)
• Ig_6 (PF18452)

Transmembrane Regions

336-356

Cellular Location

Membrane

Gene sequence

>lcl|BSEQ0052792|Interleukin-1 receptor-like 2 (IL1RL2)
ATGTGGTCCTTGCTGCTCTGCGGGTTGTCCATCGCCCTTCCACTGTCTGTCACAGCAGAT
GGATGCAAGGACATTTTTATGAAAAATGAGATACTTTCAGCAAGCCAGCCTTTTGCTTTT
AATTGTACATTCCCTCCCATAACATCTGGGGAAGTCAGTGTAACATGGTATAAAAATTCT
AGCAAAATCCCAGTGTCCAAAATCATACAGTCTAGAATTCACCAGGACGAGACTTGGATT
TTGTTTCTCCCCATGGAATGGGGGGACTCAGGAGTCTACCAATGTGTTATAAAGGGTAGA
GACAGCTGTCATAGAATACATGTAAACCTAACTGTTTTTGAAAAACATTGGTGTGACACT
TCCATAGGTGGTTTACCAAATTTATCAGATGAGTACAAGCAAATATTACATCTTGGAAAA
GATGATAGTCTCACATGTCATCTGCACTTCCCGAAGAGTTGTGTTTTGGGTCCAATAAAG
TGGTATAAGGACTGTAACGAGATTAAAGGGGAGCGGTTCACTGTTTTGGAAACCAGGCTT
TTGGTGAGCAATGTCTCGGCAGAGGACAGAGGGAACTACGCGTGTCAAGCCATACTGACA
CACTCAGGGAAGCAGTACGAGGTTTTAAATGGCATCACTGTGAGCATTACAGAAAGAGCT
GGATATGGAGGAAGTGTCCCTAAAATCATTTATCCAAAAAATCATTCAATTGAAGTACAG
CTTGGTACCACTCTGATTGTGGACTGCAATGTAACAGACACCAAGGATAATACAAATCTA
CGATGCTGGAGAGTCAATAACACTTTGGTGGATGATTACTATGATGAATCCAAACGAATC
AGAGAAGGGGTGGAAACCCATGTCTCTTTTCGGGAACATAATTTGTACACAGTAAACATC
ACCTTCTTGGAAGTGAAAATGGAAGATTATGGCCTTCCTTTCATGTGCCACGCTGGAGTG
TCCACAGCATACATTATATTACAGCTCCCAGCTCCGGATTTTCGAGCTTACTTGATAGGA
GGGCTTATCGCCTTGGTGGCTGTGGCTGTGTCTGTTGTGTACATATACAACATTTTTAAG
ATCGACATTGTTCTTTGGTATCGAAGTGCCTTCCATTCTACAGAGACCATAGTAGATGGG
AAGCTGTATGACGCCTATGTCTTATACCCCAAGCCCCACAAGGAAAGCCAGAGGCATGCC
GTGGATGCCCTGGTGTTGAATATCCTGCCCGAGGTGTTGGAGAGACAATGTGGATATAAG
TTGTTTATATTCGGCAGAGATGAATTCCCTGGACAAGCCGTGGCCAATGTCATCGATGAA
AACGTTAAGCTGTGCAGGAGGCTGATTGTCATTGTGGTCCCCGAATCGCTGGGCTTTGGC
CTGTTGAAGAACCTGTCAGAAGAACAAATCGCGGTCTACAGTGCCCTGATCCAGGACGGG
ATGAAGGTTATTCTCATTGAGCTGGAGAAAATCGAGGACTACACAGTCATGCCAGAGTCA
ATTCAGTACATCAAACAGAAGCATGGTGCCATCCGGTGGCATGGGGACTTCACGGAGCAG
TCACAGTGTATGAAGACCAAGTTTTGGAAGACAGTGAGATACCACATGCCGCCCAGAAGG
TGTCGGCCGTTTCCTCCGGTCCAGCTGCTGCAGCACACACCTTGCTACCGCACCGCAGGC
CCAGAACTAGGCTCAAGAAGAAAGAAGTGTACTCTCACGACTGGCTAA

Chromosome Location

2

Locus

2q12.1

External Identifiers

Resource	Link
UniProtKB ID	Q9HB29
UniProtKB Entry Name	ILRL2_HUMAN
HGNC ID	HGNC:5999

General References

Not Available

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB15626	Spesolimab	approved, investigational	yes	antagonist	Details