Programmed cell death 1 ligand 1

Details

Name
Programmed cell death 1 ligand 1
Synonyms
  • B7 homolog 1
  • B7-H1
  • B7H1
  • PD-L1
  • PDCD1L1
  • PDCD1LG1
  • PDL1
Gene Name
CD274
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006712|Programmed cell death 1 ligand 1
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEME
DKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGG
ADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTH
LVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
Number of residues
290
Molecular Weight
33275.095
Theoretical pI
7.25
GO Classification
Processes
cell surface receptor signaling pathway / immune response / negative regulation of activated T cell proliferation / negative regulation of interferon-gamma production / negative regulation of interleukin-10 production / negative regulation of tumor necrosis factor superfamily cytokine production / positive regulation of cell migration / positive regulation of interleukin-10 secretion / positive regulation of T cell proliferation / response to cytokine / signal transduction / T cell costimulation / toxin transport
Components
endomembrane system / external side of plasma membrane / extracellular exosome / integral component of membrane / plasma membrane
General Function
Not Available
Specific Function
Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
Pfam Domain Function
Transmembrane Regions
239-259
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0019421|Programmed cell death 1 ligand 1 (CD274)
ATGAGGATATTTGCTGTCTTTATATTCATGACCTACTGGCATTTGCTGAACGCCCCATAC
AACAAAATCAACCAAAGAATTTTGGTTGTGGATCCAGTCACCTCTGAACATGAACTGACA
TGTCAGGCTGAGGGCTACCCCAAGGCCGAAGTCATCTGGACAAGCAGTGACCATCAAGTC
CTGAGTGGTAAGACCACCACCACCAATTCCAAGAGAGAGGAGAAGCTTTTCAATGTGACC
AGCACACTGAGAATCAACACAACAACTAATGAGATTTTCTACTGCACTTTTAGGAGATTA
GATCCTGAGGAAAACCATACAGCTGAATTGGTCATCCCAGAACTACCTCTGGCACATCCT
CCAAATGAAAGGACTCACTTGGTAATTCTGGGAGCCATCTTATTATGCCTTGGTGTAGCA
CTGACATTCATCTTCCGTTTAAGAAAAGGGAGAATGATGGATGTGAAAAAATGTGGCATC
CAAGATACAAACTCAAAGAAGCAAAGTGATACACATTTGGAGGAGACGTAA
Chromosome Location
9
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9NZQ7
UniProtKB Entry NamePD1L1_HUMAN
GenBank Gene IDBC113736
GenAtlas IDCD274
HGNC IDHGNC:17635
General References
  1. Dong H, Zhu G, Tamada K, Chen L: B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med. 1999 Dec;5(12):1365-9. [Article]
  2. Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, Honjo T: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med. 2000 Oct 2;192(7):1027-34. [Article]
  3. He XH, Xu LH, Liu Y: Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain. Acta Pharmacol Sin. 2005 Apr;26(4):462-8. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11595Atezolizumabapproved, investigationalyesinhibitorantibodyDetails
DB11945Avelumabapproved, investigationalyesinhibitorantibodyDetails
DB11714Durvalumabapproved, investigationalyesinhibitorantibodyDetails
DB15769EnvafolimabinvestigationalunknowninhibitorantibodyDetails
DB15770CosibelimabinvestigationalunknowninhibitorantibodyDetails
DB15771AUNP-12investigationalunknowninhibitorantibodyDetails
DB15772CA-170investigationalunknowninhibitorDetails
DB15773anti-OX40 antibody BMS 986178investigationalunknowninhibitorDetails