Reaction: Pioglitazone to 1 product

Reaction
Pioglitazone
DB01132
    Pioglitazone metabolite M-I
    DBMET01300
    Reaction type
    O-dealkylation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    inactive
    References
    1. Jaakkola T, Laitila J, Neuvonen PJ, Backman JT: Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51. doi: 10.1111/j.1742-7843.2006.pto_437.x. [Article]
    Comments
    Not Available
    Enzymes
    Not Available