Reaction: Testosterone undecanoate to 1 product

Reaction
Testosterone undecanoate
DB13946Thumb
    Reaction type
    hydrolysis
    Direction
    Major circulating metabolite?
    Yes
    Spontaneous?
    No
    Activity
    active
    References
    1. BS DJHMB: Androgen Physiology, Pharmacology and Abuse . [Article]
    2. Ando T, Nishiyama T, Takizawa I, Ishizaki F, Miyashiro Y, Takeda K, Hara N, Tomita Y: Dihydrotestosterone synthesis pathways from inactive androgen 5alpha-androstane-3beta,17beta-diol in prostate cancer cells: Inhibition of intratumoural 3beta-hydroxysteroid dehydrogenase activities by abiraterone. Sci Rep. 2016 Aug 26;6:32198. doi: 10.1038/srep32198. [Article]
    3. Lachance S, Dhingra O, Bernstein J, Gagnon S, Savard C, Pelletier N, Boudreau N, Levesque A: Importance of measuring testosterone in enzyme-inhibited plasma for oral testosterone undecanoate androgen replacement therapy clinical trials. Future Sci OA. 2015 Nov 1;1(4):FSO55. doi: 10.4155/fso.15.55. eCollection 2015 Nov. [Article]
    4. Steroidal [Link]
    5. Metabolism of Dihydrotestosterone in Human Liver [File]
    Comments
    Not Available
    Enzymes
    Not Available