Reaction: Spironolactone to 1 product

Reaction
Spironolactone
DB00421
    7-alpha-thiospironolactone
    DBMET02481
    Reaction type
    deacetylation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. LaCagnin LB, Lutsie P, Colby HD: Conversion of spironolactone to 7 alpha-thiomethylspironolactone by hepatic and renal microsomes. Biochem Pharmacol. 1987 Oct 15;36(20):3439-44. [Article]
    2. Los LE, Pitzenberger SM, Ramjit HG, Coddington AB, Colby HD: Hepatic metabolism of spironolactone. Production of 3-hydroxy-thiomethyl metabolites. Drug Metab Dispos. 1994 Nov-Dec;22(6):903-8. [Article]
    3. Overdiek HW, Merkus FW: The metabolism and biopharmaceutics of spironolactone in man. Rev Drug Metab Drug Interact. 1987;5(4):273-302. doi: 10.1515/dmdi.1987.5.4.273. [Article]
    4. Karim A: Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. Drug Metab Rev. 1978;8(1):151-88. doi: 10.3109/03602537808993782. [Article]
    5. FDA Approved Drug Products: ALDACTONE (spironolactone) tablets, for oral use (December 2022) [Link]
    Comments
    Not Available
    Enzymes
    Not Available