Reaction: Alpelisib to 1 product

Reaction
Alpelisib
DB12015
    Alpelisib M4 Metabolite
    DBMET02571
    Reaction type
    Substitution
    Direction
    Major circulating metabolite?
    Yes
    Spontaneous?
    No
    Activity
    unknown
    References
    1. James AD, Marvalin C, Luneau A, Meissner A, Camenisch G: Comparison of (19)F NMR and (14)C Measurements for the Assessment of ADME of BYL719 (Alpelisib) in Humans. Drug Metab Dispos. 2017 Aug;45(8):900-907. doi: 10.1124/dmd.117.075424. Epub 2017 May 31. [Article]
    2. James A, Blumenstein L, Glaenzel U, Jin Y, Demailly A, Jakab A, Hansen R, Hazell K, Mehta A, Trandafir L, Swart P: Absorption, distribution, metabolism, and excretion of [(14)C]BYL719 (alpelisib) in healthy male volunteers. Cancer Chemother Pharmacol. 2015 Oct;76(4):751-60. doi: 10.1007/s00280-015-2842-4. Epub 2015 Aug 8. [Article]
    Comments
    Not Available
    Enzymes
    Not Available