Reaction: Fludrocortisone to 1 product

Reaction
Fludrocortisone
DB00687
    6β-hydroxyfluorocortisol
    DBMET02846
    Reaction type
    6-hydroxylation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Abel SM, Back DJ, Maggs JL, Park BK: Cortisol metabolism by human liver in vitro--IV. Metabolism of 9 alpha-fluorocortisol by human liver microsomes and cytosol. J Steroid Biochem Mol Biol. 1993 Dec;46(6):833-9. doi: 10.1016/0960-0760(93)90326-r. [Article]
    Comments
    The specific enzyme responsible for this conversion is unclear, however studies looking at the in vitro metabolism of fludrocortisone have observed this metabolite only after incubation in liver microsome (with none generated following incubation in liver cytosol).
    Enzymes
    Not Available