Reaction: Lamotrigine to 1 product

Reaction
Lamotrigine
DB00555
lamotrigine-2-N-glucuronide
DBMET00466
Reaction type
glucuronidation
Direction
Not Available
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Milosheska D, Lorber B, Vovk T, Kastelic M, Dolzan V, Grabnar I: Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: Influence of polymorphism of UDP-glucuronosyltransferases and drug transporters. Br J Clin Pharmacol. 2016 Aug;82(2):399-411. doi: 10.1111/bcp.12984. Epub 2016 May 29. [Article]
  2. Lamictal FDA Label [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
UDP-glucuronosyltransferases (UGTs)Not AvailableNot Availableconfirmed