Reaction: Hydrocortisone to 4 products

Reaction
Hydrocortisone
DB00741
    Tetrahydrocortisol Glucuronide 1
    DBMET02905
    Tetrahydrocortisol Glucuronide 2
    DBMET02904
    Tetrahydrocortisone Glucuronide 1
    DBMET02906
    Tetrahydrocortisone Glucuronide 2
    DBMET02907
    Reaction type
    O-glucuronidation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    inactive
    References
    1. Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR: Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor. Drug Metab Dispos. 2015 Jul;43(7):1091-9. doi: 10.1124/dmd.115.063495. Epub 2015 Apr 29. [Article]
    Comments
    Not Available
    Enzymes
    Not Available