Reaction: Fostemsavir to 1 product

Reaction
Fostemsavir
DB11796
Temsavir
DBMET03183
Reaction type
hydrolysis
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Wang T, Ueda Y, Zhang Z, Yin Z, Matiskella J, Pearce BC, Yang Z, Zheng M, Parker DD, Yamanaka GA, Gong YF, Ho HT, Colonno RJ, Langley DR, Lin PF, Meanwell NA, Kadow JF: Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir. J Med Chem. 2018 Jul 26;61(14):6308-6327. doi: 10.1021/acs.jmedchem.8b00759. Epub 2018 Jul 13. [Article]
  2. FDA Approved Drug Products: Rukobia (fostemsavir) extended-release tablets [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Intestinal-type alkaline phosphataseNot AvailableNot Availableimplied