Reaction: Cedazuridine to 1 product

Reaction
Cedazuridine
DB15694
    (4S)-2′-Deoxy-2′,2′-difluoro-3,4,5,6-tetrahydrouridine
    DBMET03186
    Reaction type
    epimerization
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Ferraris D, Duvall B, Delahanty G, Mistry B, Alt J, Rojas C, Rowbottom C, Sanders K, Schuck E, Huang KC, Redkar S, Slusher BB, Tsukamoto T: Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. J Med Chem. 2014 Mar 27;57(6):2582-8. doi: 10.1021/jm401856k. Epub 2014 Feb 24. [Article]
    2. FDA Approved Drug Products: INQOVI (decitabine and cedazuridine) oral tablets [Link]
    Comments
    Not Available
    Enzymes
    Not Available