Reaction: Diltiazem to 1 product

Reaction
Diltiazem
DB00343
Deacetyl diltiazem
DBMET03224
Reaction type
deacetylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Yeung PK, Prescott C, Haddad C, Montague TJ, McGregor C, Quilliam MA, Xei M, Li R, Farmer P, Klassen GA: Pharmacokinetics and metabolism of diltiazem in healthy males and females following a single oral dose. Eur J Drug Metab Pharmacokinet. 1993 Apr-Jun;18(2):199-206. doi: 10.1007/BF03188796. [Article]
  2. Molden E, Asberg A, Christensen H: Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared with CYP3A4. Drug Metab Dispos. 2002 Jan;30(1):1-3. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Liver esterasesNot AvailableNot Availableimplied