Reaction: Temozolomide to 1 product

Reaction
Temozolomide
DB00853
    5-(3-methyltriazen-1-yl) imidazole-4-carboxamide (MTIC)
    DBMET03267
    Reaction type
    hydrolysis
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Zhang J, Stevens MF, Bradshaw TD: Temozolomide: mechanisms of action, repair and resistance. Curr Mol Pharmacol. 2012 Jan;5(1):102-14. doi: 10.2174/1874467211205010102. [Article]
    2. Baker SD, Wirth M, Statkevich P, Reidenberg P, Alton K, Sartorius SE, Dugan M, Cutler D, Batra V, Grochow LB, Donehower RC, Rowinsky EK: Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer. Clin Cancer Res. 1999 Feb;5(2):309-17. [Article]
    3. Denny BJ, Wheelhouse RT, Stevens MF, Tsang LL, Slack JA: NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA. Biochemistry. 1994 Aug 9;33(31):9045-51. doi: 10.1021/bi00197a003. [Article]
    4. FDA Approved Drug Products: TEMODAR (temozolomide) capsules and injection [Link]
    Comments
    Not Available
    Enzymes
    Not Available