Reaction: Serdexmethylphenidate to 1 product

Reaction
Serdexmethylphenidate
DB16629
    Dexmethylphenidate
    DB06701
    Reaction type
    hydrolysis
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    active
    References
    1. Childress AC, Komolova M, Sallee FR: An update on the pharmacokinetic considerations in the treatment of ADHD with long-acting methylphenidate and amphetamine formulations. Expert Opin Drug Metab Toxicol. 2019 Nov;15(11):937-974. doi: 10.1080/17425255.2019.1675636. Epub 2019 Nov 8. [Article]
    2. Sun Z, Murry DJ, Sanghani SP, Davis WI, Kedishvili NY, Zou Q, Hurley TD, Bosron WF: Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. J Pharmacol Exp Ther. 2004 Aug;310(2):469-76. doi: 10.1124/jpet.104.067116. Epub 2004 Apr 13. [Article]
    3. Loureiro-Vieira S, Costa VM, de Lourdes Bastos M, Carvalho F, Capela JP: Methylphenidate effects in the young brain: friend or foe? Int J Dev Neurosci. 2017 Aug;60:34-47. doi: 10.1016/j.ijdevneu.2017.04.002. Epub 2017 Apr 13. [Article]
    4. Markowitz JS, Straughn AB, Patrick KS: Advances in the pharmacotherapy of attention-deficit-hyperactivity disorder: focus on methylphenidate formulations. Pharmacotherapy. 2003 Oct;23(10):1281-99. doi: 10.1592/phco.23.12.1281.32697. [Article]
    5. FDA Approved Drug Products: AZSTARYS (serdexmethylphenidate and dexmethylphenidate) capsules [Link]
    Comments
    Not Available
    Enzymes
    Not Available