Reaction: Vildagliptin to 1 product

Reaction
Vildagliptin
DB04876
    Vildagliptin M15.3 metabolite
    DBMET03320
    Reaction type
    Amide Hydrolysis
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    inactive
    References
    1. He H, Tran P, Yin H, Smith H, Batard Y, Wang L, Einolf H, Gu H, Mangold JB, Fischer V, Howard D: Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans. Drug Metab Dispos. 2009 Mar;37(3):536-44. doi: 10.1124/dmd.108.023010. Epub 2008 Dec 15. [Article]
    2. He H, Tran P, Yin H, Smith H, Flood D, Kramp R, Filipeck R, Fischer V, Howard D: Disposition of vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in rats and dogs. Drug Metab Dispos. 2009 Mar;37(3):545-54. doi: 10.1124/dmd.108.023002. Epub 2008 Dec 15. [Article]
    Comments
    Not Available
    Enzymes
    Not Available