Reaction: Carbamazepine to 1 product

Reaction
Carbamazepine
DB00564
    Carbamazepine 2,3-epoxide
    DBMET00804
    Reaction type
    Not Available
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [Article]
    2. Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS: Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine. Drug Metab Dispos. 2008 Aug;36(8):1637-49. doi: 10.1124/dmd.107.019562. Epub 2008 May 7. [Article]
    Comments
    Not Available
    Enzymes
    Not Available