Reaction: Loperamide to 1 product

Reaction
Reaction type
N-hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Kalgutkar AS, Nguyen HT: Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event. Drug Metab Dispos. 2004 Sep;32(9):943-52. [Article]
Comments
Not Available
Enzymes
Not Available