Reaction: Loperamide to 1 product
- Reaction
- Reaction type
- N-hydroxylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- inactive
- References
- Kalgutkar AS, Nguyen HT: Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event. Drug Metab Dispos. 2004 Sep;32(9):943-52. [Article]
- Comments
- Not Available
- Enzymes
- Not Available