Reaction: Ursodeoxycholic acid to 1 product

Reaction
Ursodeoxycholic acid
DB01586
    7-oxo-lithocholic acid
    DBMET03599
    Reaction type
    Dehydroxylation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Zheng M, Wang R, Li C, Xu J: Two-step enzymatic synthesis of ursodeoxycholic acid with a new 7β-hydroxysteroid dehydrogenase from Ruminococcus torques Process Biochemistry. 2015 April 1;50(4):598-604. [Article]
    2. Lee JY, Arai H, Nakamura Y, Fukiya S, Wada M, Yokota A: Contribution of the 7beta-hydroxysteroid dehydrogenase from Ruminococcus gnavus N53 to ursodeoxycholic acid formation in the human colon. J Lipid Res. 2013 Nov;54(11):3062-9. doi: 10.1194/jlr.M039834. Epub 2013 Jun 1. [Article]
    3. FDA Approved Drug Products: URSO 250 and URSO FORTE (ursodiol) tablets, for oral use [Link]
    Comments
    Not Available
    Enzymes
    Not Available