Reaction: Trametinib to 1 product
deacetylation; hydroxylationMetabolism of Trametinib
Trametinib is converted to Trametinib M3 metabolite.
- Reaction
- Direction
- Activity
- active
- Comments
- In vitro, the M3 metabolite demonstrated approximately equal or 10-fold less potent activity to inhibit phospho-MEK1 activity than the parent compound, trametinib.
What you can answer from here — as of March 20, 2023
Which metabolites of Trametinib are active, and how do they change its interactions?
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