Reaction: Vismodegib to 1 product

Reaction
Vismodegib
DB08828
    Vismodegib M14 metabolite
    DBMET03663
    Reaction type
    oxidation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Graham RA, Lum BL, Morrison G, Chang I, Jorga K, Dean B, Shin YG, Yue Q, Mulder T, Malhi V, Xie M, Low JA, Hop CE: A single dose mass balance study of the Hedgehog pathway inhibitor vismodegib (GDC-0449) in humans using accelerator mass spectrometry. Drug Metab Dispos. 2011 Aug;39(8):1460-7. doi: 10.1124/dmd.111.039339. Epub 2011 May 20. [Article]
    Comments
    Not Available
    Enzymes
    Not Available