Agmatine sulfateProduct ingredient for Agmatine
- Name
- Agmatine sulfate
- Drug Entry
- Agmatine
Agmantine is a natural metabolite of the amino acid arginine. It is formed when arginine is decarboxylated by the enzyme arginine decarboxylase and is found naturally in ragweed pollen, ergot fungi, octopus muscle, herring sperm, sponges, and the mammalian brain. Agmatine is both an experimental and investigational drug. As an investigational drug, it is being studied in a non-blinded prospective case study in the United States looking at patients who have been diagnosed with small fiber peripheral neuropathy between the ages of 18 to 75 years. Up to now (July 2013), the results of this study have not yet been published. As an experimental drug, agmatine is being studied for several indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection (stroke, severe CNS injuries, epilepsy, glaucoma, and neuropathic pain), and psychiatric conditions (depression, anxiety, schizophrenia, and cognition). The exact mechanism of action is still being investigated for all of the potential indications of agmatine.
- Accession Number
- DBSALT000006
- Structure
Structure for Agmatine sulfate (DBSALT000006)
- Synonyms
- Not Available
- External IDs
- NIH-11035
- UNII
- RU0176QL8I
- CAS Number
- 2482-00-0
- Weight
- Average: 228.27
Monoisotopic: 228.08922571 - Chemical Formula
- C5H16N4O4S
- InChI Key
- PTAYFGHRDOMJGC-UHFFFAOYSA-N
- InChI
- InChI=1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
- IUPAC Name
- N-(4-aminobutyl)guanidine; sulfuric acid
- SMILES
- OS(O)(=O)=O.NCCCCNC(N)=N
- External Links
- PubChem Compound
- 2794990
- ChemSpider
- 2073875
- ChEMBL
- CHEMBL1256618
- Wikipedia
- Agmatine
- Predicted Properties
Property Value Source Water Solubility 3.61 mg/mL ALOGPS logP -1 ALOGPS logP -1.2 Chemaxon logS -1.6 ALOGPS pKa (Strongest Basic) 12.61 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 87.92 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 48.09 m3·mol-1 Chemaxon Polarizability 15.03 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon