Besifloxacin hydrochlorideProduct ingredient for Besifloxacin

Show full entry for Besifloxacin
Name
Besifloxacin hydrochloride
Drug Entry
Besifloxacin

Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis. FDA approved on May 28, 2009.

See full entry for Besifloxacin
Accession Number
DBSALT000018
Structure
Similar Structures
Synonyms
Not Available
External IDs
BOL-303224-A / SS734
UNII
7506A6J57T
CAS Number
405165-61-9
Weight
Average: 430.301
Monoisotopic: 429.102225204
Chemical Formula
C19H22Cl2FN3O3
InChI Key
PMQBICKXAAKXAY-HNCPQSOCSA-N
InChI
InChI=1S/C19H21ClFN3O3.ClH/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23;/h7,9-11H,1-6,8,22H2,(H,26,27);1H/t10-;/m1./s1
IUPAC Name
7-[(3R)-3-aminoazepan-1-yl]-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
SMILES
Cl.[H][C@@]1(N)CCCCN(C1)C1=C(F)C=C2C(=O)C(=CN(C3CC3)C2=C1Cl)C(O)=O
PubChem Compound
10224595
ChemSpider
8400086
ChEBI
775712
ChEMBL
CHEMBL1201761
Wikipedia
Besifloxacin
Predicted Properties
PropertyValueSource
Water Solubility0.143 mg/mLALOGPS
logP0.7ALOGPS
logP0.54Chemaxon
logS-3.4ALOGPS
pKa (Strongest Acidic)5.45Chemaxon
pKa (Strongest Basic)9.84Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area86.87 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity101.75 m3·mol-1Chemaxon
Polarizability38.93 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon