Chloroquine phosphateProduct ingredient for Chloroquine

Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria.⁴ It was the drug of choice to treat malaria until the development of newer antimalarials such as pyrimethamine, artemisinin, and mefloquine.¹⁷ Chloroquine and its derivative hydroxychloroquine have since been repurposed for the treatment of a number of other conditions including HIV, systemic lupus erythematosus, and rheumatoid arthritis.¹⁸

The FDA emergency use authorization for hydroxychloroquine and chloroquine in the treatment of COVID-19 was revoked on 15 June 2020.²¹

Chloroquine was granted FDA Approval on 31 October 1949.²⁰