Metformin hydrochlorideProduct ingredient for Metformin

Name
Metformin hydrochloride
Drug Entry
Metformin

Metformin is an antihyperglycemic agent of the biguanide class, used for the management of type II diabetes) Label. Currently, metformin is the first drug of choice for the management of type II diabetes and is prescribed to at least 120 million people worldwide 14.

Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. Metformin is commonly described as an insulin sensitizer leading to a decrease in insulin resistance and a clinically significant reduction of plasma fasting insulin levels 14. Another well-known benefit of this drug is modest weight loss. Metformin is the drug of choice for obese type II diabetes patients 12.

Metformin was first approved in Canada in 1972 8, followed by 1995 in the USA Label. This drug is available in regular and extended-release forms Label.

Accession Number
DBSALT000114
Structure
Thumb
Synonyms
Metformin HCl
UNII
786Z46389E
CAS Number
1115-70-4
Weight
Average: 165.625
Monoisotopic: 165.078123116
Chemical Formula
C4H12ClN5
InChI Key
OETHQSJEHLVLGH-UHFFFAOYSA-N
InChI
InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
IUPAC Name
1-carbamimidamido-N,N-dimethylmethanimidamide hydrochloride
SMILES
Cl.CN(C)C(=N)NC(N)=N
PubChem Compound
14219
ChemSpider
13583
ChEBI
6802
ChEMBL
CHEMBL1703
Wikipedia
Metformin
Predicted Properties
PropertyValueSource
Water Solubility1.38 mg/mLALOGPS
logP-1.8ALOGPS
logP-0.92ChemAxon
logS-2ALOGPS
pKa (Strongest Basic)12.33ChemAxon
Physiological Charge2ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area88.99 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity56.64 m3·mol-1ChemAxon
Polarizability13.43 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon