Buclizine hydrochlorideProduct ingredient for Buclizine
- Name
- Buclizine hydrochloride
- Drug Entry
- Buclizine
Buclizine is an antihistamine medication with both antiemetic and anticholinergic effects 5, belonging to the piperazine derivative family of drugs. It was manufactured by Stuart Pharms and initially approved by the FDA in 1957.4 Following this, it was touted to be effective as an appetite stimulant in children when administered in the syrup form, however, this indication has not been validated.1 In addition to the above conditions, buclizine has been studied in the treatment of migraine attacks and in the treatment of nausea and vomiting during pregnancy. 2,3
- Accession Number
- DBSALT000197
- Structure
Structure for Buclizine hydrochloride (DBSALT000197)
- Synonyms
- Buclizine HCl
- UNII
- 58FQD093NU
- CAS Number
- 129-74-8
- Weight
- Average: 505.95
Monoisotopic: 504.186582251 - Chemical Formula
- C28H35Cl3N2
- InChI Key
- SDBHDSZKNVDKNU-UHFFFAOYSA-N
- InChI
- InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H
- IUPAC Name
- 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)(phenyl)methyl]piperazine dihydrochloride
- SMILES
- Cl.Cl.CC(C)(C)C1=CC=C(CN2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)C=C1
- External Links
- PubChem Compound
- 65463
- ChemSpider
- 58916
- ChEBI
- 61193
- ChEMBL
- CHEMBL2360580
- Wikipedia
- Buclizine
- Predicted Properties
Property Value Source Water Solubility 0.000246 mg/mL ALOGPS logP 6.16 ALOGPS logP 7.42 Chemaxon logS -6.2 ALOGPS pKa (Strongest Basic) 7.6 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 6.48 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 133.02 m3·mol-1 Chemaxon Polarizability 50.59 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon