Amantadine hydrochlorideProduct ingredient for Amantadine

Name
Amantadine hydrochloride
Drug Entry
Amantadine

An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.

Accession Number
DBSALT000203
Structure
Thumb
Synonyms
Amantadine HCl
External IDs
ADS-5102
UNII
M6Q1EO9TD0
CAS Number
665-66-7
Weight
Average: 187.71
Monoisotopic: 187.112777288
Chemical Formula
C10H18ClN
InChI Key
WOLHOYHSEKDWQH-UHFFFAOYSA-N
InChI
InChI=1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
IUPAC Name
adamantan-1-amine hydrochloride
SMILES
Cl.NC12CC3CC(CC(C3)C1)C2
KEGG Compound
C07939
PubChem Compound
64150
ChemSpider
57724
ChEBI
2619
ChEMBL
CHEMBL1569
Wikipedia
Amantadine
Predicted Properties
PropertyValueSource
Water Solubility0.0846 mg/mLALOGPS
logP2.53ALOGPS
logP1.47ChemAxon
logS-3.2ALOGPS
pKa (Strongest Basic)10.71ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area26.02 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity45.54 m3·mol-1ChemAxon
Polarizability17.92 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon