Sotalol hydrochlorideProduct ingredient for Sotalol

Name
Sotalol hydrochloride
Drug Entry
Sotalol

Sotalol is a methanesulfonanilide developed in 1960.6 It was the first of the class III anti arrhythmic drugs.6 Sotalol was first approved as an oral tablet on 30 October 1992.8 A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventricular arrhythmias and maintaining normal sinus rhythm in atrial fibrillation or flutter.Label,9,10

Accession Number
DBSALT000318
Structure
Synonyms
Sotalol HCl
UNII
HEC37C70XX
CAS Number
959-24-0
Weight
Average: 308.825
Monoisotopic: 308.096140945
Chemical Formula
C12H21ClN2O3S
InChI Key
VIDRYROWYFWGSY-UHFFFAOYSA-N
InChI
InChI=1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H
IUPAC Name
N-(4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}phenyl)methanesulfonamide hydrochloride
SMILES
Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1
PubChem Compound
66245
ChemSpider
59630
ChEBI
9207
ChEMBL
CHEMBL1700
Wikipedia
Sotalol
Predicted Properties
PropertyValueSource
Water Solubility0.782 mg/mLALOGPS
logP0.85ALOGPS
logP-0.4Chemaxon
logS-2.5ALOGPS
pKa (Strongest Acidic)10.07Chemaxon
pKa (Strongest Basic)9.43Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area78.43 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity71.12 m3·mol-1Chemaxon
Polarizability29.34 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon