Leucovorin calciumProduct ingredient for Leucovorin

Leucovorin, also known as folinic acid or citrovorum factor, is a reduced form of folic acid that serves as a vital coenzyme in nucleic acid synthesis.^5,1 Unlike folic acid, leucovorin does not require the enzyme dihydrofolate reductase (DHFR) for activation, allowing it to function even when DHFR is inhibited by drugs like methotrexate.^4,5 Historically developed in 1945, leucovorin has long been a staple on the World Health Organization’s List of Essential Medicines.² It is primarily indicated for "leucovorin rescue" to diminish the hematologic and mucosal toxicity of high-dose methotrexate therapy in osteosarcoma and to treat inadvertent overdoses of folic acid antagonists.^4,5 Additionally, it is used in combination with 5-fluorouracil (5-FU) to enhance therapeutic efficacy in the palliative treatment of advanced colorectal cancer and to treat megaloblastic anemias resulting from folate deficiency when oral therapy is not feasible.^4,1 Leucovorin has been explored experimentally for autism spectrum disorder.^2,3